公开(公告)号：US07008957B2

公开(公告)日：2006-03-07

申请号：US10898751

申请日：2004-07-26

申请人： Holger Wagner ,  Karl Schoenafinger ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

发明人： Holger Wagner ,  Karl Schoenafinger ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

IPC分类号： A61K31/428 ,  A61K31/454 ,  A61K31/5377 ,  C07D417/02 ,  C07D277/60

CPC分类号： C07D487/04

摘要： The invention relates to compounds of the formula I in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their preparation. The compounds are suitable for the treatment of metabohlic disorders such as type 2 diabetes.

摘要翻译： 本发明涉及式Ⅰ化合物，其中基团具有所述含义，它们的立体异构形式及其生理上可耐受的盐及其制备方法。 该化合物适用于治疗代谢性疾病如2型糖尿病。

公开(公告)号：US20050059724A1

公开(公告)日：2005-03-17

申请号：US10898752

申请日：2004-07-26

申请人： Karl Schoenafinger ,  Holger Wagner ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

发明人： Karl Schoenafinger ,  Holger Wagner ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

IPC分类号： C07D487/04 ,  A61K31/407

CPC分类号： C07D487/04

摘要： The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts, physiologically functional derivatives and process for their preparation. The compounds are suitable for the treatment of disorders of metabolism, such as type 2 diabetes.

摘要翻译： 本发明涉及式I化合物，其中基团具有文中所述的含义，它们的立体异构形式及其生理学上可耐受的盐，生理功能衍生物及其制备方法。 该化合物适用于治疗代谢紊乱，如2型糖尿病。

公开(公告)号：US20080234317A1

公开(公告)日：2008-09-25

申请号：US12046920

申请日：2008-03-12

申请人： Heinz-Werner KLEEMANN ,  Hans-Jochen LANG ,  Uwe HEINELT ,  Armin HOFMEISTER ,  Holger GAUL ,  Ulrich Hendrich SCHROEDER ,  Klaus REYMANN

发明人： Heinz-Werner KLEEMANN ,  Hans-Jochen LANG ,  Uwe HEINELT ,  Armin HOFMEISTER ,  Holger GAUL ,  Ulrich Hendrich SCHROEDER ,  Klaus REYMANN

IPC分类号： A61K31/47 ,  A61P25/00

CPC分类号： A61K31/47

摘要： The present invention comprises the use of pharmaceutical compositions that are effective in the inhibition of the Na+/H+ exchanger, subtype 5 (NHE-5) as inhibitors of cellular NHE-5 enhance long term potentiation (LTP) and are therefore effective in the treatment of memory impairments, dementing disorders, and for improving memory. Particularly suitable for the treatment of neurodegenerative disorders, memory impairments and dementing disorders, and for improving memory, are the following NHE-5 inhibitors of the formula I Wherein the R1-R8 substituents are further defined herein:

摘要翻译： 本发明包括使用有效抑制作为细胞NHE抑制剂的第5型（NHE-5）型的Na + / H + -5增强长期增强（LTP），因此有效治疗记忆障碍，痴呆症和改善记忆。 特别适用于治疗神经变性疾病，记忆障碍和痴呆病症以及改善记忆力，是下列式I的NHE-5抑制剂，其中R1-R8取代基在本文中进一步定义：

公开(公告)号：US07094800B2

公开(公告)日：2006-08-22

申请号：US10898752

申请日：2004-07-26

申请人： Karl Schoenafinger ,  Holger Wagner ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

发明人： Karl Schoenafinger ,  Holger Wagner ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

IPC分类号： A61K31/40 ,  A61K31/4439 ,  C07D209/02 ,  C07D401/02

CPC分类号： C07D487/04

摘要： The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts, physiologically functional derivatives and process for their preparation. The compounds are suitable for the treatment of disorders of metabolism, such as type 2 diabetes.

摘要翻译： 本发明涉及式I化合物，其中基团具有文中所述的含义，它们的立体异构形式及其生理学上可耐受的盐，生理功能衍生物及其制备方法。 该化合物适用于治疗代谢紊乱，如2型糖尿病。

公开(公告)号：US08020746B2

公开(公告)日：2011-09-20

申请号：US12439883

申请日：2007-09-04

申请人： Ute Geissler ,  Herbert Reichl ,  Holger Gaul ,  Klaus-Dieter Lang ,  Martin Schneider-Ramelow

发明人： Ute Geissler ,  Herbert Reichl ,  Holger Gaul ,  Klaus-Dieter Lang ,  Martin Schneider-Ramelow

IPC分类号： B23K20/10 ,  B23K1/06

CPC分类号： B23K20/005 ,  H01L24/45 ,  H01L24/48 ,  H01L24/78 ,  H01L24/85 ,  H01L2224/45015 ,  H01L2224/45124 ,  H01L2224/45144 ,  H01L2224/4847 ,  H01L2224/78313 ,  H01L2224/78318 ,  H01L2224/8518 ,  H01L2224/85206 ,  H01L2224/859 ,  H01L2924/01013 ,  H01L2924/01019 ,  H01L2924/01033 ,  H01L2924/01041 ,  H01L2924/01057 ,  H01L2924/01074 ,  H01L2924/01079 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/20303 ,  H01L2924/20304 ,  H01L2924/20305 ,  H01L2924/20751 ,  H01L2924/20752 ,  H01L2924/20753 ,  H01L2924/20754 ,  H01L2924/20755 ,  H01L2924/20756 ,  H01L2924/20757 ,  H01L2924/20758 ,  H01L2924/20759 ,  H01L2924/2076 ,  H01L2924/01014 ,  H01L2924/00014 ,  H01L2924/00

摘要： A method for generating a wire bond between a wire and an electrical contact member is provided. The method comprising the steps of: pressing a first surface of a portion of the wire against a second surface of the electrical contact member with a first force while vibrating the portion of the wire along the second surface in order to generate a bond; measuring the time dependent vibration amplitude of the portion of the wire at a number of discrete time steps during the generation of the bond; measuring the time dependent deformation of said portion of the wire due to said applied first force and said vibration at a number of discrete time steps during the generation of the bond; and generating a time dependent first signal from at least said vibration amplitude and said deformation at a number of discrete time steps during the generation of the bond that is a direct measure of the stability of the bond at the respective time step.

摘要翻译： 提供了一种用于在线和电接触构件之间产生引线接合的方法。 该方法包括以下步骤：使电极的一部分的第一表面以第一力按压电接触构件的第二表面，同时沿着第二表面振动电极的该部分以产生接合; 在产生粘结期间在多个离散时间步长下测量导线部分的时间相关振动幅度; 在产生所述键期间，由于所述施加的第一力和所述振动在多个离散的时间步长处测量所述导线的所述部分的随时间变化; 以及在产生所述键期间的至少所述振动振幅和所述变形的多个离散时间步长产生时间依赖的第一信号，所述键是在各个时间步长期间所述键的稳定性的直接测量。

公开(公告)号：US20100025453A1

公开(公告)日：2010-02-04

申请号：US12439883

申请日：2007-09-04

申请人： Ute Geissler ,  Herbert Reichl ,  Holger Gaul ,  Klaus-Dieter Lang ,  Martin Schneider-Ramelow

发明人： Ute Geissler ,  Herbert Reichl ,  Holger Gaul ,  Klaus-Dieter Lang ,  Martin Schneider-Ramelow

IPC分类号： B23K20/10 ,  B23K37/00

CPC分类号： B23K20/005 ,  H01L24/45 ,  H01L24/48 ,  H01L24/78 ,  H01L24/85 ,  H01L2224/45015 ,  H01L2224/45124 ,  H01L2224/45144 ,  H01L2224/4847 ,  H01L2224/78313 ,  H01L2224/78318 ,  H01L2224/8518 ,  H01L2224/85206 ,  H01L2224/859 ,  H01L2924/01013 ,  H01L2924/01019 ,  H01L2924/01033 ,  H01L2924/01041 ,  H01L2924/01057 ,  H01L2924/01074 ,  H01L2924/01079 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/20303 ,  H01L2924/20304 ,  H01L2924/20305 ,  H01L2924/20751 ,  H01L2924/20752 ,  H01L2924/20753 ,  H01L2924/20754 ,  H01L2924/20755 ,  H01L2924/20756 ,  H01L2924/20757 ,  H01L2924/20758 ,  H01L2924/20759 ,  H01L2924/2076 ,  H01L2924/01014 ,  H01L2924/00014 ,  H01L2924/00

摘要： A method for generating a wire bond between a wire and an electrical contact member is provided. The method comprising the steps of: pressing a first surface of a portion of the wire against a second surface of the electrical contact member with a first force while vibrating the portion of the wire along the second surface in order to generate a bond; measuring the time dependent vibration amplitude of the portion of the wire at a number of discrete time steps during the generation of the bond; measuring the time dependent deformation of said portion of the wire due to said applied first force and said vibration at a number of discrete time steps during the generation of the bond; and generating a time dependent first signal from at least said vibration amplitude and said deformation at a number of discrete time steps during the generation of the bond that is a direct measure of the stability of the bond at the respective time step.

摘要翻译： 提供了一种用于在线和电接触构件之间产生引线接合的方法。 该方法包括以下步骤：使电极的一部分的第一表面以第一力按压电接触构件的第二表面，同时沿着第二表面振动电极的该部分以产生接合; 在产生粘结期间在多个离散时间步长下测量导线部分的时间相关振动幅度; 在产生所述键期间，由于所述施加的第一力和所述振动在多个离散的时间步长处测量所述导线的所述部分的随时间变化; 以及在产生所述键期间的至少所述振动振幅和所述变形的多个离散时间步长产生时间依赖的第一信号，所述键是在各个时间步长期间所述键的稳定性的直接测量。

公开(公告)号：US20050059716A1

公开(公告)日：2005-03-17

申请号：US10898751

申请日：2004-07-26

申请人： Holger Wagner ,  Karl Schoenafinger ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

发明人： Holger Wagner ,  Karl Schoenafinger ,  Gerhard Jaehne ,  Holger Gaul ,  Christian Buning ,  Georg Tschank ,  Ulrich Werner

IPC分类号： C07D487/04 ,  C07D513/02 ,  A61K31/4188 ,  A61K31/424 ,  A61K31/428

CPC分类号： C07D487/04

摘要： The invention relates to compounds of the formula I in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their preparation. The compounds are suitable for the treatment of metabohlic disorders such as type 2 diabetes.

摘要翻译： 本发明涉及式Ⅰ化合物，其中基团具有所述含义，它们的立体异构形式及其生理上可耐受的盐及其制备方法。 该化合物适用于治疗代谢性疾病如2型糖尿病。

公开(公告)号：US5101039A

公开(公告)日：1992-03-31

申请号：US468567

申请日：1990-01-23

申请人： Hansjorg Urbach ,  Rainer Henning ,  Volker Teetz ,  Rolf Geiger ,  Reinhard Becker ,  Holger Gaul

发明人： Hansjorg Urbach ,  Rainer Henning ,  Volker Teetz ,  Rolf Geiger ,  Reinhard Becker ,  Holger Gaul

IPC分类号： A61K38/55 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  C07D209/02 ,  C07D209/08 ,  C07D209/32 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07D215/22 ,  C07D215/227 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

CPC分类号： C07D215/227 ,  C07D209/08 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07K5/0222 ,  A61K38/00

摘要： Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0, 1 or 2, R.sub.1 denotes hydrogen (C.sub.1 -C.sub.6)-alkyl which can optionally be substituted by amino, (C.sub.1 -C.sub.4)-acyl- or bezoylamino, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.5 C.sub.9)-cycloalkenyl, (C.sub.5 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C.sub.1 C.sub.2)-alkyl, (C.sub.1 -C.sub.2)-alkoxy or halogen, aryl-(C.sub.1 -C.sub.4)-alkyl, [which can be substituted as defined previously in the aryl radical], a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R.sub.2 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl or aryl-(C.sub.1 -C.sub.4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C.sub.1 - C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, hydroxyl, halogen, nitro, amino, (C.sub.1 -C.sub.4)-alkylamino, di-(C.sub.1 -C.sub.4 -alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process of the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.

公开(公告)号：US5008400A

公开(公告)日：1991-04-16

申请号：US673605

申请日：1984-11-21

申请人： Hansjorg Urbach ,  Rainer Henning ,  Volker Teetz ,  Rolf Geiger ,  Reinhard Becker ,  Holger Gaul

发明人： Hansjorg Urbach ,  Rainer Henning ,  Volker Teetz ,  Rolf Geiger ,  Reinhard Becker ,  Holger Gaul

IPC分类号： A61K38/55 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  C07D209/02 ,  C07D209/08 ,  C07D209/32 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07D215/22 ,  C07D215/227 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

CPC分类号： C07D215/227 ,  C07D209/08 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07K5/0222 ,  A61K38/00

摘要： Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0,1 or 2, R.sub.1 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl which can optionally by substituted by amino, (C.sub.1 -C.sub.4)-acyl- or bezoylamino, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.5 -C.sub.9)-cycloalkenyl, (C.sub.5 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C.sub.1 -C.sub.2)-alkyl, (C.sub.2 -C.sub.2)-alkoxy or halogen, aryl-(C.sub.1 -C.sub.4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R.sub.2 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl or aryl-(C.sub.1 -C.sub.4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C.sub.1 - C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, hydroxyl, halogen, nitro, amino, (C.sub.1 -C.sub.4)-alkylamino, di-(C.sub.1 -C.sub.4)-alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process for the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.

公开(公告)号：US4933361A

公开(公告)日：1990-06-12

申请号：US346339

申请日：1989-04-28

申请人： Hansjorg Urbach ,  Rainer Henning ,  Volker Teetz ,  Rolf Geiger ,  Reinhard Becker ,  Holger Gaul

发明人： Hansjorg Urbach ,  Rainer Henning ,  Volker Teetz ,  Rolf Geiger ,  Reinhard Becker ,  Holger Gaul

IPC分类号： A61K38/55 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  C07D209/02 ,  C07D209/08 ,  C07D209/32 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07D215/22 ,  C07D215/227 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

CPC分类号： C07D215/227 ,  C07D209/08 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07K5/0222 ,  A61K38/00

摘要： Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0, 1 or 2, R.sub.1 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl which can optionally be substituted by amino, (C.sub.1 -C.sub.4)-acyl- or bezoylamino, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.5 -C.sub.9)-cycloalkenyl, (C.sub.5 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C.sub.1 -C.sub.2)-alkyl, (C.sub.1 -C.sub.2)-alkoxy or halogen, aryl-(C.sub.1 -C.sub.4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R.sub.2 denotes hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl or aryl-(C.sub.1 -C.sub.4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.6 -C.sub.9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, hydroxyl, halogen, nitro, amino, (C.sub.1 -C.sub.4)-alkylamino, di-(C.sub.1 -C.sub.4 -alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process of the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.

摘要翻译： 公开了式I的顺式，外转和反式化合物，其中n表示0,1或2，R 1表示氢，可任选被氨基取代的（C 1 -C 6） - 烷基，（C 1 -C 6 - （C 5 -C 9） - 环烷基，（C 5 -C 9） - 环烯基，（C 5 -C 7） - 环烷基 - （C 1 -C 4） - 烷基，芳基或 部分氢化的芳基，在每种情况下均可被（C 1 -C 2） - 烷基，（C 1 -C 2） - 烷氧基或卤素，芳基 - （C 1 -C 4） - 烷基取代， 在芳基/，单环或双环硫或氮和/或氮杂环基或天然存在的氨基酸的侧链中，R 2表示氢，（C 1 -C 6） - 烷基，（C 2 -C 6） - 烯基或芳基 - （C1-C4） - 烷基，Y表示氢或羟基，Z表示氢或Y，Z表示氧，X表示（C1-C6） - 烷基，（C2-C6） - 烯基，（C6-C9） 环烷基或芳基，其可以被（C 1 -C 4） - 烷基，（C 1 -C 4） - 烷氧基，羟基，卤素，硝基，氨基，（C 1 -C 4） 烷基氨基，二 - （C 1 -C 4 - 烷基氨基或亚甲二氧基或吲哚-3-基）或其生理上可接受的盐，其制备方法，含有它们的试剂，它们作为药物的用途和制备它们的中间体。