Abstract:
The present invention provides novel, long-acting nanoformulated drugs and targeted drug delivery methods, and uses thereof. In one embodiment, the nanoformulated drug is a retroviral drug. In one embodiment, the nanoformulated composition comprises a nanocarrier with one or more incorporated drugs. In an exemplary embodiment, the drug is efavirenz (EFV). In a further embodiment, the nanocarrier is associated with an agent for targeting microfold cells (M-cells). In a specific embodiment, the targeting agent binds to an M-cell marker known as glycoprotein 2 (GP2). Via this mechanism, the nanodrug is targeted toward GALT.
Abstract:
A method and apparatus for handover between base stations are disclosed. The method includes: a first base station sending handover request messages to neighboring base stations (401); the neighboring base stations judging whether to accept the handover according to information in the handover request messages, and sending judgment results to the first base station through request response messages (402); the first base station determining one destination base station from the neighboring base stations which are able to accept the handover, and sending a confirmation handover message to the destination base station (403); the destination base station allocating resources for a user equipment after receiving the confirmation handover message, and sending the allocated resources to the first base station through a confirmation handover response message (404); and the first base station indicating that the user equipment hands over to the destination base station after receiving the confirmation handover response message (405).
Abstract:
The present invention provides a kind of permanent magnetic lifting device, which has: a housing, at the bottom of which is a clamping surface for clamping objects; fixed magnet(s), set in housing relatively fixed to housing; a turnable magnet, set in housing relatively turnable to fixed magnet. When turnable magnet is in the first position relative to fixed magnet, the magnetic force generated by fixed magnet and turnable magnet to clamping surface is zero magnetic force; when turnable magnet is in the third position relative to fixed magnet, the magnetic force generated by fixed magnet and turnable magnet to clamping surface is the maximum magnetic force. The permanent magnetic lifting device also has a positioning mechanism for second position. When the positioning mechanism for second position positions turnable magnet in the second position relative to fixed magnet, fixed magnet and turnable magnet generate trial clamping magnetic force to clamping surface for clamping objects on trial. The trial clamping magnetic force is higher than zero magnetic force and lower than maximum magnetic force. The permanent magnetic lifting device enables an operator to easily operate trial clamping, and also to know whether the ratio of the maximum clamping force that can be generated by the permanent magnetic lifting device under the specific condition to the weight of the workpiece equals or exceeds 2 times or 3 times or other specific values, and through operation of trial clamping, potential risk in safety can be thoroughly eliminated.
Abstract:
A system and method for automatically focusing an optical lens controls the light generated by a light-emitting device of an image measuring machine to penetrate a glass sheet, so as to project a picture of the glass sheet onto an object. The system and method further moves an optical lens along a Z-axis of the image measuring machine to capture one or more digital images of the object, and computes a definition value of each captured digital image. Furthermore, the system and method obtains a focus position corresponding to the highest definition value of the captured digital image.
Abstract:
The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.
Abstract:
The present invention relates to a portable communication device and an antenna unit. The device includes a display having a display surface, a transparent non-conductive display window covering the display surface of the display, and an antenna having at least one antenna element, wherein the antenna element is provided as a transparent conductive layer provided on the display cover. With this antenna solution space is freed inside the device for use for other units or for further size reductions. Light passing through the window is furthermore not blocked.
Abstract:
Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
Abstract:
A 2K basecoat clearcoat system includes a solvent borne basecoat having a low Tg branched polyester polyol, optionally, a high Tg, high molecular weight thermoplastic resin, and a hardener that includes an isocyanate functional material suitable for crosslinking the polyester polyol, and optional thermoplastic resin. The solvent borne clearcoat composition includes a low Tg linear or branched polyester polyol, at least one other multi-functional polyol, and an isocyanate functional material suitable for crosslinking the polyester and multi-functional polyols.
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Abstract:
Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.