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    CHEMICAL PROCESS FOR THE PREPARATION OF INTERMEDIATES TO OBTAIN N-FORMYL HYDROXYLAMINE COMPOUNDS
    4.
    发明申请
    CHEMICAL PROCESS FOR THE PREPARATION OF INTERMEDIATES TO OBTAIN N-FORMYL HYDROXYLAMINE COMPOUNDS 审中-公开
    制备中间体以获得N-甲醛羟基胺化合物的化学方法

    公开(公告)号：US20090131707A1

    公开(公告)日：2009-05-21

    申请号：US12272552

    申请日：2008-11-17

    申请人： Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Koteswara Kapa ,  Michael John Girgis

    发明人： Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Koteswara Kapa ,  Michael John Girgis

    IPC分类号： C07C227/16

    CPC分类号： C07D401/12 ,  C07B2200/07 ,  C07C51/487 ,  C07C239/20 ,  C07C59/01

    摘要： Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular I3-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxypropionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.

    摘要翻译： 用于制备可用于制备抗菌N- [1-氧代-2-烷基-3-（N-羟基甲酰氨基） - 丙基} - （羰基氨基 - 芳基或 - 杂芳基） - 偶氮环-4-烯烷或噻唑烷-4-7烷烃的中间体的改进方法，其具有一个或 更多的以下特点：（1）利用特定的内酰胺中间体; （2），其使用特定的拆分剂，对映体纯的取代的丙酸，特别是（R）-2-丁基-3-羟基丙酸; （3）避免使用过氧化氢; 和（4）促进选择性脱苄基化减少废弃副产物的生产。

    High efficiency compact Cybagfilter
    6.
    发明授权
    High efficiency compact Cybagfilter 失效
    高效紧凑型Cybagfilter

    公开(公告)号：US5961675A

    公开(公告)日：1999-10-05

    申请号：US83119

    申请日：1998-05-22

    申请人： Jae-Ik Son ,  Young-Ok Park ,  Cheol-Oh Koo ,  Jeong-Hwan Lim ,  Hong-Yong Kim ,  Sang-Do Kim ,  Tae-Hee Chun ,  Hyock-Ju Kwon

    发明人： Jae-Ik Son ,  Young-Ok Park ,  Cheol-Oh Koo ,  Jeong-Hwan Lim ,  Hong-Yong Kim ,  Sang-Do Kim ,  Tae-Hee Chun ,  Hyock-Ju Kwon

    IPC分类号： B04C9/00 ,  B01D45/12 ,  B01D46/02 ,  B01D46/04 ,  B01D50/00

    CPC分类号： B01D46/0068 ,  B01D45/12 ,  B01D46/02 ,  B01D46/4281 ,  B01D50/002

    摘要： A high efficiency compact gas-particulate separator is provided comprising: a bag filter disposed above and a cyclone disposed below,the bag filter including: a casing, a compressed air header into the casing; a diaphragm valve on the header; a blow tube connected to the header; a venturi for accelerating an ejected jet of compressed air from the blow tube and for inducing an inflow of secondary air; and a filter bag for collecting dusts mounted in the casing; the casing having a clean air outlet, andthe cyclone including: a dust-laden gas inlet; an outer cylinder for generating a centrifugal force, the cylinder being connected to the casing; an inner tube for letting a dust-laden gas pass from below upward into the casing; and a dust hopper for storing dust particles captured by centrifugal forces and dislodged dust cakes removed from the filter bag by cleaning.

    摘要翻译： 提供了一种高效率紧凑型气体 - 微粒分离器，其包括：设置在上方的袋式过滤器和设置在下方的旋风分离器，所述袋式过滤器包括：壳体，压缩空气集管进入所述壳体; 集管上的隔膜阀; 连接到集管的吹管; 文丘里管，用于加速来自吹管的喷射的压缩空气流并引起二次空气的流入; 以及用于收集安装在所述壳体中的灰尘的过滤袋; 所述壳体具有清洁空气出口，所述旋风分离器包括：载有灰尘的气体入口; 用于产生离心力的外筒，所述气缸连接到所述壳体; 用于使载满灰尘的气体从下方向下进入壳体的内管; 以及用于存储由离心力捕获的灰尘颗粒和通过清洁从过滤袋移除的移动的粉尘饼的垃圾斗。

    Quinazolinone Derivatives Useful as Vanilloid Antagonists
    7.
    发明申请
    Quinazolinone Derivatives Useful as Vanilloid Antagonists 有权
    喹唑啉酮衍生物作为香草素拮抗剂有用

    公开(公告)号：US20100197705A1

    公开(公告)日：2010-08-05

    申请号：US12683317

    申请日：2010-01-06

    申请人： Weichun Chen ,  Hong-Yong Kim ,  Jessica Liang ,  Michael Mutz ,  Mahavir Prashad ,  Christopher Towler ,  Ruoqiu Wu

    发明人： Weichun Chen ,  Hong-Yong Kim ,  Jessica Liang ,  Michael Mutz ,  Mahavir Prashad ,  Christopher Towler ,  Ruoqiu Wu

    IPC分类号： A61K31/517 ,  C07D239/88 ,  A61P29/00 ,  A61P21/00 ,  A61P19/02

    CPC分类号： C07D239/91 ,  A61K31/517

    摘要： There is described a new polymorphic form of 4-(7-Hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile having structural formula I(B) and to a method of preparing it.There is further a process or method for the manufacture of a pharmaceutically active quinazolinone compounds of the formula I wherein the symbols have the meanings given in the description, said process comprising reacting a compound of the formula II, wherein R4* is R1*—C(═O)— wherein R1* is independently selected from the group of meanings of R1 as defined for a compound of the formula I so that R1* and R1 are identical to or different from each other, or R4* is especially H, and R1 and R3, R5 and R6 are as defined for a compound of the formula I, or a salt thereof, under simultaneous or sequential condensation and cyclisation conditions with an aniline compound of the formula III, wherein R2 and m are as defined for a compound of the formula I. Further reactions and related embodiments are also claimed and disclosed.

    摘要翻译： 描述了具有结构式I（B）的4-（7-羟基-2-异丙基-4-氧代-4H-喹唑啉-3-基） - 苄腈的新的多晶型物及其制备方法。 还有一种用于制备式I的药学活性喹唑啉酮化合物的方法或方法，其中符号具有在说明书中给出的含义，所述方法包括使式II化合物，其中R4 *是R1 * -C （ΟO） - 其中R 1 *独立地选自如式I化合物所定义的R 1的含义，使得R 1 *和R 1彼此相同或不同，或者R 4 *特别是H，和 R 1和R 3，R 5和R 6如式I化合物或其盐在同时或连续的缩合和环化条件下与式III的苯胺化合物所定义，其中R 2和m如化合物 其他反应和相关实施方案也被要求保护和公开。

    Chemical process for the preparation of intermediates to obtain n-formyl hydroxy-lamine compounds
    8.
    发明申请
    Chemical process for the preparation of intermediates to obtain n-formyl hydroxy-lamine compounds 失效
    用于制备中间体以获得正甲酰基羟基 - 胺化合物的化学方法

    公开(公告)号：US20070179298A1

    公开(公告)日：2007-08-02

    申请号：US10544919

    申请日：2004-02-20

    申请人： Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Kapa ,  Michael Girgis

    发明人： Mahavir Prashad ,  Hong-Yong Kim ,  Bin Hu ,  Joel Slade ,  Prasad Kapa ,  Michael Girgis

    IPC分类号： A61K31/4439 ,  C07D417/02 ,  C07D403/02

    CPC分类号： C07D401/12 ,  C07B2200/07 ,  C07C51/487 ,  C07C239/20 ,  C07C59/01

    摘要： Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular β-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxy-propionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.

    摘要翻译： 用于制备可用于制备抗菌N- [1-氧代-2-烷基-3-（N-羟基甲酰氨基） - 丙基} - （羰基氨基 - 芳基或 - 杂芳基） - 偶氮基-4-7烷烃或噻唑烷-4-醇的中间体的改进方法，其具有 一个或多个以下特征：（1）利用特定的β-内酰胺中间体; （2），其使用特定的拆分剂，对映体纯的取代的丙酸，特别是（R）-2-丁基-3-羟基 - 丙酸; （3）避免使用过氧化氢; 和（4）促进选择性脱苄基化减少废弃副产物的生产。