利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.012 秒)

    COPPER(I)-ION SELECTIVE FLUORESCENT PROBE, METHOD FOR PREPARING THE SAME, METHOD FOR DIAGNOSING MALIGNANT DISEASE AND DIAGNOSIS KIT USING THE PROBE
    1.
    发明申请
    COPPER(I)-ION SELECTIVE FLUORESCENT PROBE, METHOD FOR PREPARING THE SAME, METHOD FOR DIAGNOSING MALIGNANT DISEASE AND DIAGNOSIS KIT USING THE PROBE 审中-公开
    铜（I）选择性荧光探针，其制备方法，使用探针诊断恶性疾病和诊断试剂盒的方法

    公开(公告)号：US20130236922A1

    公开(公告)日：2013-09-12

    申请号：US13476163

    申请日：2012-05-21

    申请人： Bong-Rae CHO ,  Hoon-Jai CHUN

    发明人： Bong-Rae CHO ,  Hoon-Jai CHUN

    IPC分类号： G01N21/64 ,  C07C323/25

    CPC分类号： G01N21/6486 ,  C07C323/25

    摘要： The present disclosure relates to a copper (I) ion-selective fluorescent probe, a method for preparing the same, and a method for diagnosing malignant disease and a diagnosis kit using the probe. The fluorescent probe according to the present disclosure is capable of detecting free copper (I) ions inside cells for a long time with high selectivity and sensitivity for copper (I) ion, with a penetration depth longer than 90 μm in living cells and tissues and without the problems of mistargeting and photobleaching. Accordingly, since a biological sample can be imaged for a long period of time with high resolution without damage, presence of malignance disease in the target biological sample can be diagnosed faster, more accurately and more easily.

    摘要翻译： 本公开涉及铜（I）离子选择性荧光探针，其制备方法，以及诊断恶性疾病的方法和使用该探针的诊断试剂盒。 根据本公开的荧光探针能够长时间检测细胞内的游离铜（I）离子，对于铜（I）离子具有高选择性和灵敏度，在活细胞和组织中的渗透深度大于90μm， 没有定位和漂白的问题。 因此，由于可以以高分辨率对生物样品长时间成像而没有损伤，因此可以更快，更准确和更容易地诊断目标生物样品中恶性疾病的存在。