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    Inhaler apparatus with modified surfaces for enhanced release of dry powders
    2.
    发明授权
    Inhaler apparatus with modified surfaces for enhanced release of dry powders 失效
    具有改性表面的吸入器装置，用于增强干粉的释放

    公开(公告)号：US06591833B2

    公开(公告)日：2003-07-15

    申请号：US09782419

    申请日：2001-02-13

    申请人： Pabitra Datta ,  Howard Christopher Rivenburg ,  Nitin Desai

    发明人： Pabitra Datta ,  Howard Christopher Rivenburg ,  Nitin Desai

    IPC分类号： A61M1500

    CPC分类号： A61M15/0045 ,  A61M15/0021 ,  A61M15/0051 ,  A61M2205/0233

    摘要： In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.

    摘要翻译： 在一个方面，本发明提供了一种吸入器装置，其包括与用于吸入的药物接触的内表面，所述内表面包括接口管的内表面和其上沉积有药物的基底，所述内表面中的至少一个包括凹陷或 凸起区域在其中，凸起区域之间具有谷部。 在某些优选实施例中，内表面是在其上沉积有药物的基底上的表面，在其它优选实施例中，内表面是吸入器的接口的内表面。 除了提供表面拓扑以最小化药物和吸入器表面之间的接触面积之外，表面优选地由具有低表面能的材料制成，并且更优选地，当不带电时也不具有实质范围 与药物的离子或静电相互作用。 此外，材料优选基本上与药物无化学反应。

    Acoustic dispenser
    4.
    发明授权
    Acoustic dispenser 失效
    声音分配器

    公开(公告)号：US5753302A

    公开(公告)日：1998-05-19

    申请号：US661211

    申请日：1996-06-10

    申请人： Hoi Cheong Steve Sun ,  Pabitra Datta ,  William Yat Chung Chiang ,  Howard Christopher Rivenburg ,  Bawa Singh ,  Dominic S. Rosati ,  James Regis Matey

    发明人： Hoi Cheong Steve Sun ,  Pabitra Datta ,  William Yat Chung Chiang ,  Howard Christopher Rivenburg ,  Bawa Singh ,  Dominic S. Rosati ,  James Regis Matey

    IPC分类号： A61K41/00 ,  B05B5/047 ,  B05B17/06 ,  B05D1/06 ,  B05B7/00 ,  B05C3/05 ,  B05D1/12

    CPC分类号： A61K41/00 ,  A61K41/0014 ,  B05B17/06 ,  B05B5/047 ,  B01J2219/00468

    摘要： The present invention provides an acoustic dispenser for propelling objects toward a substrate, together with methods of use of the dispenser. The acoustic dispenser uses a source of acoustic vibration and a membrane for the application of acoustic vibration wherein the objects are propelled from the membrane to a substrate. The acoustic dispenser and the methods of the invention can be used with numerous types of objects. In some embodiments, the objects are particles in a dry powder, which can include, for example, a pharmaceutically active ingredient. In other embodiments, the objects are beads, which preferably have an average diameter of about 100 to about 300 microns. Additionally, the acoustic dispenser can be used with more than one type of object, for example, two types of objects such as beads and dry powder. In some instances, the acoustic dispenser further comprises a membrane for separating one type of object from the other based on size, whereby one type of object is separated from the other prior to deposition.

    摘要翻译： 本发明提供一种用于将物体推向基板的声学分配器，以及分配器的使用方法。 声学分配器使用声振动源和用于施加声振动的膜，其中物体从膜推进到基底。 声音分配器和本发明的方法可以与许多类型的物体一起使用。 在一些实施方案中，物体是干粉末中的颗粒，其可以包括例如药物活性成分。 在其它实施方案中，物体是珠，其优选具有约100至约300微米的平均直径。 此外，声音分配器可以与多于一种类型的物体一起使用，例如两种类型的物体，例如珠粒和干粉。 在一些情况下，声音分配器还包括用于基于尺寸将一种类型的物体与另一种物体分离的膜，由此在沉积之前一种类型的物体与另一种物体分离。

    Bead or particle manipulating chucks
    5.
    发明授权
    Bead or particle manipulating chucks 失效
    珠或粒子操纵卡盘

    公开(公告)号：US06295194B1

    公开(公告)日：2001-09-25

    申请号：US09393871

    申请日：1999-09-10

    申请人： Hoi Cheong Sun ,  Bawa Singh ,  Howard Christopher Rivenburg

    发明人： Hoi Cheong Sun ,  Bawa Singh ,  Howard Christopher Rivenburg

    IPC分类号： H02N1300

    CPC分类号： B82Y15/00 ,  B01J2219/00468 ,  B01J2219/005 ,  H02N1/004

    摘要： Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.

    摘要翻译： 提供了一种将带电粒子从第一位置移动到第一位置的方法，其中第二位置被第二电极保持在第二位置，该方法包括：向第二电极施加电位以吸引 粒子; 以及将电位施加到在所述第一位置处偏离所述粒子的引导电极，其中所施加的电位有效地减小所述粒子对所述第一位置的吸引力，以足以允许施加在所述第二电极处的电位有效地移动 颗粒从第一位置到第二位置。

    Inhaler apparatus with an electronic means for enhanced release of dry powders
    7.
    发明授权
    Inhaler apparatus with an electronic means for enhanced release of dry powders 失效
    具有电子装置的吸入装置，用于增强干粉的释放

    公开(公告)号：US5857456A

    公开(公告)日：1999-01-12

    申请号：US661212

    申请日：1996-06-10

    申请人： Hoi Cheong Steve Sun ,  Bawa Singh ,  Howard Christopher Rivenburg ,  Pabitra Datta ,  Nitin Vithabhi Desai

    发明人： Hoi Cheong Steve Sun ,  Bawa Singh ,  Howard Christopher Rivenburg ,  Pabitra Datta ,  Nitin Vithabhi Desai

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M2205/0233

    摘要： The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate. In other preferred embodiments, the inhaler apparatus further comprises a third conductive layer positioned below the substrate, and the voltage source is preferably connected to the second conductive layer above the substrate and the third conductive layer below the substrateIn another aspect, the present invention provides a method for dispensing a medicant from an inhaler, comprising: (a) providing an inhaler with a substrate having a medicant deposited thereon, the substrate comprising a conductive layer and a dielectric layer and a voltage source connected to said conductive layer; and (b) actuating the voltage source.

    摘要翻译： 本发明部分地涉及具有沉积有药剂的基底的吸入器装置，该基底被配置为电子释放药物。 在优选实施例中，吸入器在其上包括导电层和介电层。 在优选实施例中，吸入器还包括位于衬底上方的第二导电层，而不与衬底接触。 在某些优选实施例中，电压源连接到衬底中的导电层和衬底上方的第二导电层。 在其它优选实施例中，吸入器装置还包括位于衬底下方的第三导电层，并且电压源优选地连接到衬底上方的第二导电层和衬底下方的第三导电层。在另一方面，本发明提供 一种从吸入器分配药物的方法，包括：（a）为吸入器提供具有沉积在其上的药物的基底，所述基底包括导电层和电介质层以及连接到所述导电层的电压源; 和（b）致动电压源。

    Spraying device for dispensing home care formulations with electrostatic liquid droplets
    9.
    发明授权
    Spraying device for dispensing home care formulations with electrostatic liquid droplets 失效
    用于分配具有静电液滴的家庭护理配方的喷涂装置

    公开(公告)号：US06474563B2

    公开(公告)日：2002-11-05

    申请号：US09794441

    申请日：2001-02-27

    申请人： Timothy Allen Pletcher ,  Peter John Zanzucchi ,  Robert Richard Demers ,  Howard Christopher Rivenburg

    发明人： Timothy Allen Pletcher ,  Peter John Zanzucchi ,  Robert Richard Demers ,  Howard Christopher Rivenburg

    IPC分类号： B05B5025

    CPC分类号： B05B5/1691 ,  B05B5/047

    摘要： A spraying device for dispensing electrostatic liquid droplets includes a container holding a liquid at one end, and having a nozzle assembly with an aperture at another end. The nozzle assembly includes a longitudinal hollow tube terminating in a metallic structure. The metallic structure includes a metallic base plate having at least one aperture formed therein for fluid communication with the hollow tube. The longitudinal hollow tube includes an end inserted in the liquid. A charge accumulator disposed in the liquid accumulates electrostatic charges. A wire conductor between the base plate and the charge accumulator transfers the electrostatic charges from the liquid to the nozzle assembly.

    摘要翻译： 用于分配静电液滴的喷射装置包括在一端保持液体的容器，并且具有在另一端具有孔的喷嘴组件。 喷嘴组件包括终止于金属结构的纵向中空管。 金属结构包括金属底板，其具有形成在其中的至少一个孔，用于与中空管流体连通。 纵向中空管包括插入液体中的端部。 设置在液体中的电荷蓄积剂蓄积静电电荷。 基板和充电蓄能器之间的导线将静电电荷从液体转移到喷嘴组件。

    Inhaler apparatus with modified surfaces for enhanced release of dry powders
    10.
    发明授权
    Inhaler apparatus with modified surfaces for enhanced release of dry powders 失效
    具有改进表面的吸入器装置，用于增强干粉的释放

    公开(公告)号：US06298847B1

    公开(公告)日：2001-10-09

    申请号：US09210214

    申请日：1998-12-11

    申请人： Pabitra Datta ,  Howard Christopher Rivenburg ,  Nitin Desai

    发明人： Pabitra Datta ,  Howard Christopher Rivenburg ,  Nitin Desai

    IPC分类号： A61M1500

    CPC分类号： A61M15/0045 ,  A61M15/0021 ,  A61M15/0051 ,  A61M2205/0233

    摘要： In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.

    摘要翻译： 在一个方面，本发明提供了一种吸入器装置，其包括与用于吸入的药物接触的内表面，所述内表面包括接口管的内表面和其上沉积有药物的基底，所述内表面中的至少一个包括凹陷或 凸起区域在其中，凸起区域之间具有谷部。 在某些优选实施例中，内表面是在其上沉积有药物的基底上的表面，在其它优选实施例中，内表面是吸入器的接口的内表面。 除了提供用于使药物和吸入器的表面之间的接触面积最小化的表面拓扑之外，表面优选地由具有低表面能的材料制成，并且更优选地，当不带电时也不具有实质的范德 与药物的离子或静电相互作用。 此外，材料优选基本上与药物无化学反应。