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    Bronchoscopic repair of air leaks in a lung
    1.
    发明申请
    Bronchoscopic repair of air leaks in a lung 有权
    支气管镜检查肺部漏气

    公开(公告)号：US20050137714A1

    公开(公告)日：2005-06-23

    申请号：US10745401

    申请日：2003-12-22

    申请人： Hugo Gonzalez ,  Steven Springmeyer ,  William Sirokman

    发明人： Hugo Gonzalez ,  Steven Springmeyer ,  William Sirokman

    IPC分类号： A61B17/12 ,  A61F2/04

    CPC分类号： A61B17/12104 ,  A61B17/12022 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00809 ,  A61B2017/12054 ,  A61F2002/043

    摘要： Methods and systems for minimally invasively treating an air leak in a lung comprise the steps of detecting an air leak in a lung; locating an airway in fluid communication with the air leak, introducing a bronchoscope into a patient's airway to a position adjacent the target section and occluding an airway upstream of the air leak for a period of time. The airway occlusion is preferably removed after the air leak has substantially permanently healed. The method can also include the injection of a substance into the airway on a distal side of the occlusion.

    摘要翻译： 用于微创侵入性处理肺部空气泄漏的方法和系统包括检测肺中的空气泄漏的步骤; 定位与空气泄漏流体连通的气道，将支气管镜引入患者的气道中至与目标部分相邻的位置，并在空气泄漏上游封闭气道一段时间。 空气泄漏基本上永久愈合之后，优选除去气道闭塞。 该方法还可以包括在闭塞的远端侧将气体注入气道中。

    Head guard for soccer players
    2.
    发明授权
    Head guard for soccer players 失效
    足球运动员的头卫

    公开(公告)号：US06374422B1

    公开(公告)日：2002-04-23

    申请号：US09853494

    申请日：2001-05-11

    申请人： Hugo Gonzalez ,  Maria Gonzalez ,  Oscar Gonzalez

    发明人： Hugo Gonzalez ,  Maria Gonzalez ,  Oscar Gonzalez

    IPC分类号： A63B7110

    CPC分类号： A42B3/00 ,  A63B71/10

    摘要： A head guard for soccer players for protecting the forehead of a soccer player when the forehead is struck with a soccer ball. The head guard for soccer players includes a plate having a outer surface and an inner surface. The plate has a bottom edge, a pair of side edges and a top edge. The inner surface is concave and the outer surface is convex. The bottom edge generally lies in a plane such that the plate generally arcs back from the bottom edge to the top edge. A head band is elongated and has a pair of ends. Each of the ends of the head band is attached to the plate and defines a loop for extending around a head such that the plate may be abutted against the forehead of the wearer. Each of the ends of the head band is positioned adjacent to the bottom edge and one of the side edges.

    摘要翻译： 足球运动员的头卫，用于保护足球运动员的前额，当前额被一个足球击中时。 足球运动员的前卫包括具有外表面和内表面的板。 该板具有底部边缘，一对侧边缘和顶部边缘。 内表面为凹面，外表面为凸面。 底部边缘通常位于一个平面中，使得该板通常从底部边缘向后退到顶部边缘。 头带是细长的并且具有一对端部。 头带的每个端部附接到板并且限定用于围绕头部延伸的环，使得板可以抵靠穿着者的前额。 头带的每个端部邻近底部边缘和一个侧边缘定位。

    Devices and methods for biomaterial production
    3.
    发明授权
    Devices and methods for biomaterial production 有权
    生物材料生产的设备和方法

    公开(公告)号：US07238522B2

    公开(公告)日：2007-07-03

    申请号：US10857439

    申请日：2004-05-27

    申请人： Henry Hebel ,  Sriram Ramakrishnan ,  Hugo Gonzalez ,  Jeff Darnell

    发明人： Henry Hebel ,  Sriram Ramakrishnan ,  Hugo Gonzalez ,  Jeff Darnell

    IPC分类号： C12M1/33

    CPC分类号： C12N15/1003 ,  B01F13/0255 ,  B03D2203/003 ,  C12M47/06 ,  C12M47/10 ,  C12N1/06 ,  C12N1/066 ,  C12N15/101

    摘要： An apparatus and a method for isolating a biologic product, such as plasmid DNA, from cells. The method involves lysing cells in a controlled manner separate insoluble components from a fluid lysate containing cellular components of interest, followed by membrane chromatographic techniques to purify the cellular components of interest. The process utilizes a unique lysis apparatus, ion exchange and, optionally, hydrophobic interaction chromatography membranes in cartridge form, and ultrafiltration. The process can be applied to any biologic product extracted from a cellular source. The process uses a lysis apparatus, including a high shear, low residence-time mixer for advantageously mixing a cell suspension with a lysis solution, a hold time that denatures impurities, and an air-sparging bubble mixer that gently yet thoroughly mixes lysed cells with a neutralization/precipitation buffer and floats compacted precipitated cellular material.

    摘要翻译： 从细胞中分离生物制品如质粒DNA的装置和方法。 该方法包括以受控的方式裂解细胞，从含有感兴趣的细胞成分的流体裂解物中分离不溶性组分，然后用膜色谱技术纯化感兴趣的细胞组分。 该方法利用独特的裂解装置，离子交换以及任选的以胶囊形式的疏水相互作用层析膜和超滤。 该方法可以应用于从细胞来源提取的任何生物制品。 该方法使用裂解装置，包括高剪切，低停留时间混合器，有利地将细胞悬浮液与裂解溶液混合，使杂质变性的保持时间和将裂解细胞轻轻地充分混合的空气鼓泡混合器 中和/沉淀缓冲液和漂浮压实的沉淀细胞材料。

    Devices and methods for biomaterial production
    5.
    发明申请
    Devices and methods for biomaterial production 有权
    生物材料生产的设备和方法

    公开(公告)号：US20050014245A1

    公开(公告)日：2005-01-20

    申请号：US10857439

    申请日：2004-05-27

    申请人： Henry Hebel ,  Sriram Ramakrishnan ,  Hugo Gonzalez ,  Jeff Darnell

    发明人： Henry Hebel ,  Sriram Ramakrishnan ,  Hugo Gonzalez ,  Jeff Darnell

    IPC分类号： B01F13/02 ,  C12N1/06 ,  C12N15/10 ,  C12P21/06 ,  C12M1/34 ,  C12N1/08

    CPC分类号： C12N15/1003 ,  B01F13/0255 ,  B03D2203/003 ,  C12M47/06 ,  C12M47/10 ,  C12N1/06 ,  C12N1/066 ,  C12N15/101

    摘要： An apparatus and a method for isolating a biologic product, such as plasmid DNA, from cells. The method involves lysing cells in a controlled manner separate insoluble components from a fluid lysate containing cellular components of interest, followed by membrane chromatographic techniques to purify the cellular components of interest. The process utilizes a unique lysis apparatus, ion exchange and, optionally, hydrophobic interaction chromatography membranes in cartridge form, and ultrafiltration. The process can be applied to any biologic product extracted from a cellular source. The process uses a lysis apparatus, including a high shear, low residence-time mixer for advantageously mixing a cell suspension with a lysis solution, a hold time that denatures impurities, and an air-sparging bubble mixer that gently yet thoroughly mixes lysed cells with a neutralization/precipitation buffer and floats compacted precipitated cellular material.

    摘要翻译： 从细胞中分离生物制品如质粒DNA的装置和方法。 该方法包括以受控的方式裂解细胞，从含有感兴趣的细胞成分的流体裂解物中分离不溶性组分，然后用膜色谱技术纯化感兴趣的细胞组分。 该方法利用独特的裂解装置，离子交换以及任选的以胶囊形式的疏水相互作用层析膜和超滤。 该方法可以应用于从细胞来源提取的任何生物制品。 该方法使用裂解装置，包括高剪切，低停留时间混合器，有利地将细胞悬浮液与裂解溶液混合，使杂质变性的保持时间和将裂解细胞轻轻地充分混合的空气鼓泡混合器 中和/沉淀缓冲液和漂浮压实的沉淀细胞材料。

    One-way valve devices for anchored implantation in a lung
    7.
    发明申请
    One-way valve devices for anchored implantation in a lung 有权
    用于锚定植入肺部的单向阀装置

    公开(公告)号：US20050033344A1

    公开(公告)日：2005-02-10

    申请号：US10933778

    申请日：2004-09-03

    申请人： David Dillard ,  Hugo Gonzalez ,  Seung Yi ,  Lauri DeVore ,  Mia Park ,  Dean Corcoran ,  Jenni Rimbaugh ,  Clifton Alferness

    发明人： David Dillard ,  Hugo Gonzalez ,  Seung Yi ,  Lauri DeVore ,  Mia Park ,  Dean Corcoran ,  Jenni Rimbaugh ,  Clifton Alferness

    IPC分类号： A61F2/04 ,  A61F2/24 ,  A61M15/00 ,  A61M16/00 ,  A61M29/00 ,  B05D7/14

    CPC分类号： A61B17/12104 ,  A61B17/12172 ,  A61B2017/00809 ,  A61F2/24 ,  A61F2002/043

    摘要： An intra-bronchial device placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes a support structure, an obstructing member carried by the support structure that reduces ventilation to the lung portion by preventing air from being inhaled into the lung portion, and at least one anchor carried by the support structure that anchors the obstruction device within the air passageway. The anchor may engage the air passageway wall by piercing or friction, include a stop dimensioned for limiting the piercing of the air passageway wall, and may be releasable from the air passageway for removal of the intra-bronchial device. The anchors may be carried by a peripheral portion of the support structure, or by a central portion of the support structure. The obstructing member may be a one-way valve.

    摘要翻译： 将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。 该装置包括支撑结构，由支撑结构承载的阻塞构件，其通过防止空气被吸入肺部而减少对肺部的通气，以及由支撑结构承载的至少一个锚固件，其将阻塞装置锚定在内部 空气通道。 锚固件可以通过穿孔或摩擦接合空气通道壁，包括尺寸适于限制空气通道壁的刺穿的止挡件，并且可以从空气通道释放以去除支气管内装置。 锚固件可以由支撑结构的周边部分或支撑结构的中心部分承载。 阻塞构件可以是单向阀。

    Tissue resection device, system, and method
    9.
    发明申请
    Tissue resection device, system, and method 失效
    组织切除装置，系统和方法

    公开(公告)号：US20050043745A1

    公开(公告)日：2005-02-24

    申请号：US10939811

    申请日：2004-09-13

    申请人： Clifton Alferness ,  Hugo Gonzalez

    发明人： Clifton Alferness ,  Hugo Gonzalez

    IPC分类号： A61B17/00 ,  A61B17/12 ,  A61F2/00 ,  A61B17/10

    CPC分类号： A61B17/12 ,  A61B17/00234 ,  A61F2/0063

    摘要： A resection device and method permits safe and efficient encapsulation, isolation and resection of body tissue. The device includes a sheath of flexible and severable material configured to receive the body tissue to be resectioned as it is drawn therein. The sheath may be expandable and held in an expanded condition as the body tissue to be resectioned is drawn into the sheath. Thereafter, the sheath is permitted to collapse about the body tissue to contain and constrict the body tissue. Once the body tissue to be resectioned is disposed in the sheath, the sheath is severed to resection the body tissue.

    摘要翻译： 切除装置和方法允许安全有效的包裹，分离和切除身体组织。 该装置包括柔性和可分割材料的护套，其被配置为在其被抽吸时接收待切除的身体组织。 当待切除的身体组织被拉入护套时，护套可以是可扩张的并且保持在扩张状态。 此后，允许护套围绕身体组织塌陷以容纳和收缩身体组织。 一旦要切除的身体组织被放置在鞘中，鞘被切断以切除身体组织。