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    Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same
    1.
    发明授权
    Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same 有权
    用于高效包封核酸和亲水性阴离子化合物的不对称脂质体及其制备方法

    公开(公告)号：US09326940B2

    公开(公告)日：2016-05-03

    申请号：US13697705

    申请日：2010-11-12

    申请人： Myung Kyu Lee ,  Abbas Mokhtarieh Amir ,  Bong Hyun Chung ,  Jong Min Choi

    发明人： Myung Kyu Lee ,  Abbas Mokhtarieh Amir ,  Bong Hyun Chung ,  Jong Min Choi

    IPC分类号： A61K9/127 ,  A61K31/122 ,  A61K31/70 ,  A61K31/713

    CPC分类号： A61K9/1272 ,  A61K9/1271 ,  A61K9/1277 ,  A61K31/122 ,  A61K31/70 ,  A61K31/713

    摘要： The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.

    摘要翻译： 本发明涉及用于核酸和亲水性阴离子化合物的高包封效率的不对称脂质体及其制备方法，具体涉及由具有小头基团作为内部脂质和中性的阳离子脂质组成的不对称脂质体 或具有大头基的聚乙二醇化脂质作为外部脂质，其中核酸和/或阴离子化合物包封在内部脂质中。 根据本发明，可以制备其中核酸和亲水性阴离子化合物以高效率包封的不对称脂质体，因此可以用于各种目的，例如基因治疗和递送亲水性阴离子药物 其难以作为前药制备，并且药物递送，成像等可以通过将荧光对比剂包封在脂质体中来进行。

    OIL FENCE AND METHOD FOR STORING SAME
    4.
    发明申请
    OIL FENCE AND METHOD FOR STORING SAME 有权
    油藏及其储存方法

    公开(公告)号：US20130343820A1

    公开(公告)日：2013-12-26

    申请号：US13992374

    申请日：2011-11-16

    申请人： Dae Jun Chang ,  Pal G Bergan ,  Hyun Chung ,  Jeong Min Kwak

    发明人： Dae Jun Chang ,  Pal G Bergan ,  Hyun Chung ,  Jeong Min Kwak

    IPC分类号： E02B15/06

    CPC分类号： E02B15/06 ,  E02B15/0807 ,  E02B15/0814 ,  E02B15/0842 ,  E02B15/085 ,  E02B15/0878 ,  Y02A20/204

    摘要： The present invention relates to an oil fence and to a method for storing same. The oil fence includes: a vertical support part on which an air chamber, a water chamber, and a ballast are successively disposed in the lengthwise direction thereof; a curtain part connected between the vertical support parts disposed parallel to and spaced a predetermined distance from each other in the widthwise direction thereof; and attenuation bags disposed on the upper and lower portions of the curtain part. Thus, the oil fence may prevent seawater containing oil from overflowing in spite of high waves. Also, the oil fence may stably float on the sea in spite of poor weather conditions and high waves and may be easily stored and unfolded.

    摘要翻译： 本发明涉及一种油栅栏及其储存方法。 油栅栏包括：纵向支撑部分，空气室，水室和镇流器沿其长度方向依次设置在该垂直支撑部分上; 连接在垂直支撑部分之间的帘幕部分，所述垂直支撑部分在其宽度方向上彼此平行并且彼此间隔开预定距离; 以及设置在帘部件的上部和下部的衰减袋。 因此，尽管有大波浪，但是油栅可防止含油的海水溢出。 此外，尽管恶劣的天气条件和高波浪，油栏也可能稳定地浮在海上，并且可以容易地储存和展开。

    Method for fabricating nanogap and nanogap sensor
    5.
    发明授权
    Method for fabricating nanogap and nanogap sensor 有权
    纳米胶和纳米胶片传感器的制造方法

    公开(公告)号：US08557567B2

    公开(公告)日：2013-10-15

    申请号：US11887978

    申请日：2006-09-05

    申请人： Bong hyun Chung ,  Sang kyu Kim ,  Hye jung Park

    发明人： Bong hyun Chung ,  Sang kyu Kim ,  Hye jung Park

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： G01N33/5438 ,  B82Y15/00 ,  C30B29/06 ,  C30B33/10

    摘要： The present invention relates to a method of fabricating a nanogap and a nanogap sensor, and to a nanogap and a nanogap sensor fabricated using the method. The present invention relates to a method of fabricating a nanogap and a nanogap sensor, which can be realized by an anisotropic etching using a semiconductor manufacturing process. According to the method of present invention, the nanogap and nanogap sensor can be simply and cheaply produced in large quantities.

    摘要翻译： 本发明涉及制造纳米隙和纳米隙传感器的方法，以及使用该方法制造的纳米隙和纳米隙传感器。 本发明涉及一种可以通过使用半导体制造工艺的各向异性蚀刻来实现的纳米隙和纳米隙传感器的制造方法。 根据本发明的方法，可以大量地简单且廉价地生产纳米隙和纳米隙传感器。

    Method for preparing antibody monolayers which have controlled orientation using peptide hybrid
    6.
    发明授权
    Method for preparing antibody monolayers which have controlled orientation using peptide hybrid 有权
    使用肽杂交制备具有受控取向的抗体单层的方法

    公开(公告)号：US08236509B2

    公开(公告)日：2012-08-07

    申请号：US12679982

    申请日：2007-10-18

    申请人： Sang Jeon Chung ,  Bong Hyun Chung ,  Yongwon Jung ,  Hyo Jin Kang ,  Jeong Min Lee

    发明人： Sang Jeon Chung ,  Bong Hyun Chung ,  Yongwon Jung ,  Hyo Jin Kang ,  Jeong Min Lee

    IPC分类号： G01N33/53

    CPC分类号： C07K17/00 ,  C07K7/02 ,  C07K7/08 ,  G01N33/54353 ,  G01N33/54393

    摘要： The present invention relates to a method for preparing an protein monolayer using a peptide hybrid for protein immobilization, more precisely a peptide hybrid for protein immobilization which has improved solubility by introducing a PEG linker and a proper reaction group to the oligopeptide having specific affinity to selected types of proteins and is designed to provide enough space between solid substrates and proteins immobilized, whereby various solid substrates treated by the hybrid catch specific proteins effectively on. The peptide hybrid for protein immobilization of the present invention facilitates the control of orientation of an antibody on various solid surfaces and immobilization of various antibodies of different origins or having different isotypes with different affinity. Therefore, the surface treatment technique using the peptide hybrid of the invention can be effectively used for the production of various immunosensors and immune chips.

    摘要翻译： 本发明涉及一种使用肽杂交体制备蛋白质单层的方法，更准确地说，用于蛋白质固定的肽杂交体，其通过将PEG接头和适当的反应基团引入具有对所选择的特异性亲和力的寡肽而具有改善的溶解性 蛋白质类型被设计为在固体底物和固定的蛋白质之间提供足够的空间，由此通过混合物处理的各种固体底物有效捕获特异性蛋白质。 用于本发明的蛋白质固定化的肽杂合物有助于控制抗体在各种固体表面上的取向并且固定不同来源的各种抗体或具有不同亲和力的不同同种型。 因此，使用本发明的肽杂交体的表面处理技术可以有效地用于生产各种免疫传感器和免疫芯片。

    Microneedle Unit Capable of Controlling Fluid Delivery
    7.
    发明申请
    Microneedle Unit Capable of Controlling Fluid Delivery 有权
    能够控制流体输送的微针单元

    公开(公告)号：US20120059326A1

    公开(公告)日：2012-03-08

    申请号：US13263306

    申请日：2010-04-08

    申请人： Bong Hyun Chung ,  Nyeon Sik Eum

    发明人： Bong Hyun Chung ,  Nyeon Sik Eum

    IPC分类号： A61M5/32 ,  A61M5/00

    CPC分类号： A61M37/0015 ,  A61M5/178 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061

    摘要： Provided is a microneedle unit comprising a case having a space accommodating a fluid and a fluid channel through which the fluid is discharged, a microneedle coupled to a lower portion of the case, a base cover disposed at the lower portion of the case, having a hole through which the microneedle passes, and being vertically movable, a guide pin coupled to the base cover and configured to open and close the fluid channel, and an elastic member configured to impart a restoring force such that the base cover is moved upward by an external pressure and then returns downward again. Therefore, the microneedle unit, which is provided to deliver a fluid into the skin with no pain and no scar, can control injection of the fluid using the guide pin, and repeatedly and conveniently control injection of the fluid using the elastic member.

    摘要翻译： 提供了一种微针单元，其包括具有容纳流体的空间和流体被排出的流体通道的壳体，连接到壳体的下部的微针，设置在壳体的下部的底盖，具有 所述微针通过所述孔并且可垂直移动;引导销，其联接到所述基座盖并且构造成打开和关闭所述流体通道;以及弹性构件，其构造成赋予恢复力，使得所述底盖向上移动一个 外部压力再次向下返回。 因此，提供用于将流体输送到皮肤中而没有疼痛和无疤痕的微针单元可以使用导销来控制流体的注入，并且使用弹性构件重复且方便地控制流体的注入。

    METHOD FOR MANUFACTURING UNIFORM SIZE POLYMERIC NANOPARTICLES CONTAINING POORLY SOLUBLE DRUGS
    9.
    发明申请
    METHOD FOR MANUFACTURING UNIFORM SIZE POLYMERIC NANOPARTICLES CONTAINING POORLY SOLUBLE DRUGS 有权
    制造含有不溶性药物的均匀聚合物纳米颗粒的方法

    公开(公告)号：US20110171269A1

    公开(公告)日：2011-07-14

    申请号：US12990540

    申请日：2009-04-30

    申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

    发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

    IPC分类号： A61K9/00 ,  A61K31/235 ,  A61P1/16 ,  B82Y40/00 ,  B82Y5/00

    CPC分类号： A61K9/1652 ,  A61K9/5153 ,  A61K31/235 ,  A61K31/343 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/573 ,  A61K31/585 ,  A61K31/704 ,  A61K31/7048 ,  B01D65/00 ,  C08J3/03 ,  Y10S516/929

    摘要： The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.

    摘要翻译： 本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将可生物降解聚合物溶解在非挥发性物质中的第一步骤 极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。 本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小而均匀的聚合物纳米颗粒 可生物降解聚合物和难溶性物质的溶液，并且使用低机械能条件和在乳化过程中分批添加分散体。 本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐且稳定地释放并保持在恒定的密度。