公开(公告)号：US07961315B2

公开(公告)日：2011-06-14

申请号：US12802890

申请日：2010-06-15

Applicant: Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

Inventor： Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

IPC: G01J3/30

CPC classification number: G01N21/648 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6428 ,  G01N33/54373 ,  G01N33/582 ,  G01N2021/7786 ,  G02B2006/1213

Abstract: Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.

公开(公告)号：US07768640B2

公开(公告)日：2010-08-03

申请号：US11986156

申请日：2007-11-19

Applicant: Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

Inventor： Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

IPC: G01J3/30

CPC classification number: G01N21/648 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6428 ,  G01N33/54373 ,  G01N33/582 ,  G01N2021/7786 ,  G02B2006/1213

Abstract: Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.

Abstract translation: 描述了结合到样品并存在于二维光子晶体表面上的荧光团的荧光发射的增强。 归因于泄漏的光子晶体本征模式（共振模式），通过高强度近场和强相干散射效应的组合来实现荧光的增强。 光子晶体同时呈现与荧光团的吸收和发射波长重叠的共振模式。 证明了来自荧光团在光子晶体表面上的荧光强度的显着增强。

公开(公告)号：US20080278722A1

公开(公告)日：2008-11-13

申请号：US11986156

申请日：2007-11-19

Applicant: Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

Inventor： Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

IPC: G01J3/30

CPC classification number: G01N21/648 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6428 ,  G01N33/54373 ,  G01N33/582 ,  G01N2021/7786 ,  G02B2006/1213

Abstract: Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.

Abstract translation: 描述了结合到样品并存在于二维光子晶体表面上的荧光团的荧光发射的增强。 归因于泄漏的光子晶体本征模式（共振模式），通过高强度近场和强相干散射效应的组合来实现荧光的增强。 光子晶体同时呈现与荧光团的吸收和发射波长重叠的共振模式。 证明了来自荧光团在光子晶体表面上的荧光强度的显着增强。

公开(公告)号：US20110031409A1

公开(公告)日：2011-02-10

申请号：US12802890

申请日：2010-06-15

Applicant: Brain T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

Inventor： Brain T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

IPC: G01J1/58

CPC classification number: G01N21/648 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6428 ,  G01N33/54373 ,  G01N33/582 ,  G01N2021/7786 ,  G02B2006/1213

Abstract: Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.

Abstract translation: 描述了结合到样品并存在于二维光子晶体表面上的荧光团的荧光发射的增强。 归因于泄漏的光子晶体本征模式（共振模式），通过高强度近场和强相干散射效应的组合来实现荧光的增强。 光子晶体同时呈现与荧光团的吸收和发射波长重叠的共振模式。 证明了来自荧光团在光子晶体表面上的荧光强度的显着增强。

公开(公告)号：US07756365B2

公开(公告)日：2010-07-13

申请号：US11822303

申请日：2007-07-02

Applicant: Brian T. Cunningham ,  Nikhil Ganesh ,  Ian D. Block

Inventor： Brian T. Cunningham ,  Nikhil Ganesh ,  Ian D. Block

IPC: G02B6/00

CPC classification number: G01N21/7743 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  B82Y20/00 ,  G01N21/253 ,  G01N21/33 ,  G01N33/54373 ,  G01N33/551 ,  G01N33/552 ,  G02B1/005

Abstract: Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. The biosensors feature a tightly confined resonant electric field at the surface of this biosensor and provide a high surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecules or ultra-low analyte concentrations.

Abstract translation: 基于在近紫外波长下操作的一维或二维光子晶体反射滤光片来公开生物传感器。 生物传感器在该生物传感器的表面具有紧密限制的共振电场，并提供对体敏感比的高表面灵敏度，因此能够增强吸附在生物传感器表面上的生物分子的检测分辨率。 这些新的生物传感器可以通过复制成型制成。 它们特别适用于需要检测小分子或超低分析物浓度的应用。