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公开(公告)号:US20060172999A1
公开(公告)日:2006-08-03
申请号:US10548678
申请日:2004-03-04
申请人: Olivier Dirat , Jason Elliott , Ian Huscroft , Richard Jelley , Janusz Kulagowski , Piotr Raubo , Duncan Shaw , Francine Sternfeld , Christopher Swain
发明人: Olivier Dirat , Jason Elliott , Ian Huscroft , Richard Jelley , Janusz Kulagowski , Piotr Raubo , Duncan Shaw , Francine Sternfeld , Christopher Swain
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4747 , A61K31/407 , A61K31/4025
CPC分类号: C07D405/04 , C07D405/06 , C07D407/12 , C07D417/04 , C07D491/10
摘要: The present invention relates to the compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and W are as defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
摘要翻译: 本发明涉及式(I)化合物,其中R 1,R 2,R 3,R 4, R 5,R 6,R 7,R 8,R 9,R 9, W和W如本文所定义,及其药学上可接受的盐; 该化合物特别用于治疗或预防抑郁,焦虑,疼痛,炎症,偏头痛,呕吐或带状疱疹后神经痛。
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公开(公告)号:US06476041B1
公开(公告)日:2002-11-05
申请号:US09696504
申请日:2000-10-25
申请人: Wayne Thompson , David A. Claremon , Peter M. Munson , Janusz Kulagowski , Willie Whitter , Ian Huscroft
发明人: Wayne Thompson , David A. Claremon , Peter M. Munson , Janusz Kulagowski , Willie Whitter , Ian Huscroft
IPC分类号: C07D47300
CPC分类号: C07D401/06 , C07D471/04 , C07D473/00
摘要: Novel piperidinyl compounds substituted in the 1- and 4-positions are effective as NMDA NR2B antagonists useful for relieving pain.
摘要翻译: 在1位和4位上取代的新型哌啶基化合物作为可用于缓解疼痛的NMDA NR2B拮抗剂是有效的。
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