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12 条记录 (耗时 0.022 秒)

    YKL-40 AS A MARKER FOR GASTROINTESTINAL CANCERS
    1.
    发明申请
    YKL-40 AS A MARKER FOR GASTROINTESTINAL CANCERS 失效
    YKL-40作为胃肠癌标志物

    公开(公告)号：US20120070853A1

    公开(公告)日：2012-03-22

    申请号：US13063402

    申请日：2009-09-14

    申请人： Julia Sidenius Johansen ,  Nicolai Aagaard Schultz ,  Benny Vittrup Jensen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    发明人： Julia Sidenius Johansen ,  Nicolai Aagaard Schultz ,  Benny Vittrup Jensen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57419 ,  G01N33/57446 ,  G01N2800/52

    摘要： The present invention relates to gastrointestinal cancers and methods for selecting a treatment for said gastrointestinal cancer in a subject. The present invention further relates to a methods of diagnosing the presence of and/or classifying the severity of a gastrointestinal cancer; together with methods for determining the effect of a therapy administered and/or the prognosis for a subject suffering from a gastrointestinal cancer, before, during or after administering the treatment. For all the methods applies that a determined level of YKL-40 above one or more reference levels indicates the treatment, the severity of the disease, the effect of the treatment and/or the prognosis of the subject. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The subject may suffer from any one or more gastrointestinal cancers, such as upper gastrointestinal cancers, and metastatic colorectal cancer. The present invention further relates to a kit and a device that may be used in the method of the present invention.

    摘要翻译： 本发明涉及胃肠癌和用于选择受治疗者中所述胃肠癌的治疗的方法。 本发明还涉及诊断胃肠癌的严重性的存在和/或分类的方法; 以及在施用治疗之前，期间或之后确定施用治疗的效果和/或患有胃肠癌患者的预后的方法。 所有方法都适用于高于一个或多个参考水平的确定水平的YKL-40表示治疗，疾病的严重程度，治疗的效果和/或预后。 参考水平通常是从健康个体获得的水平或以前从相同受试者获得的水平。 受试者可能患有任何一种或多种胃肠癌，例如上消化道癌和转移性结肠直肠癌。 本发明还涉及可用于本发明方法的试剂盒和装置。

    YKL-40 AS A GENERAL MARKER FOR NON-SPECIFIC DISEASE
    3.
    发明申请
    YKL-40 AS A GENERAL MARKER FOR NON-SPECIFIC DISEASE 失效
    YKL-40作为非特异性疾病的一般标记

    公开(公告)号：US20110045518A1

    公开(公告)日：2011-02-24

    申请号：US12812409

    申请日：2009-01-22

    申请人： Julia Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    发明人： Julia Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    IPC分类号： C12Q1/34 ,  C12Q1/37 ,  C12M1/34

    CPC分类号： G01N33/6893 ,  G01N2400/00 ,  G01N2800/50

    摘要： The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the presence of a non-specific disease or disorder. The subject may suffer from a variety of diseases or disorders. The reference level may be a reference level obtained from healthy individuals or it may be a previous measurement obtained from the same subject. The present invention furthermore relates to a method for classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above or below one or more reference levels gives the severity of said non-specific disease or disorder. The present invention further relates to a kit and a device that may be used in the method of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with at least one reference level of YKL-40.

    摘要翻译： 本发明涉及诊断受试者中非特异性疾病或病症的存在的方法，其中确定的高于参考水平的YKL-40水平表明存在非特异性疾病或病症。 受试者可能患有各种疾病或病症。 参考水平可以是从健康个体获得的参考水平，或者可以是从相同受试者获得的先前测量值。 本发明还涉及用于分类受试者中非特异性疾病或病症的严重性的方法，其中确定的YKL-40水平高于或低于一个或多个参考水平给出所述非特异性疾病的严重性或 紊乱。 本发明还涉及可用于本发明方法的试剂盒和装置，其包括用于测量样品中YKL-40水平的装置; 以及用于将YKL-40的测量水平与YKL-40的至少一个参考水平进行比较的装置。

    YKL-40 as a general marker for non-specific disease
    4.
    发明授权
    YKL-40 as a general marker for non-specific disease 失效
    YKL-40作为非特异性疾病的一般标志物

    公开(公告)号：US08697384B2

    公开(公告)日：2014-04-15

    申请号：US12812409

    申请日：2009-01-22

    申请人： Julia Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    发明人： Julia Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    IPC分类号： C12Q1/37

    CPC分类号： G01N33/6893 ,  G01N2400/00 ,  G01N2800/50

    摘要： The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the presence of a non-specific disease or disorder. The subject may suffer from a variety of diseases or disorders. The reference level may be a reference level obtained from healthy individuals or it may be a previous measurement obtained from the same subject. The present invention furthermore relates to a method for classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above or below one or more reference levels gives the severity of said non-specific disease or disorder. The present invention further relates to a kit and a device that may be used in the method of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with at least one reference level of YKL-40.

    摘要翻译： 本发明涉及诊断受试者中非特异性疾病或病症的存在的方法，其中确定的高于参考水平的YKL-40水平表明存在非特异性疾病或病症。 受试者可能患有各种疾病或病症。 参考水平可以是从健康个体获得的参考水平，或者可以是从相同受试者获得的先前测量值。 本发明还涉及用于分类受试者中非特异性疾病或病症的严重性的方法，其中确定的YKL-40水平高于或低于一个或多个参考水平给出所述非特异性疾病的严重性或 紊乱。 本发明还涉及可用于本发明方法的试剂盒和装置，其包括用于测量样品中YKL-40水平的装置; 以及用于将YKL-40的测量水平与YKL-40的至少一个参考水平进行比较的装置。

    YKL-40 as a marker for gastrointestinal cancers
    7.
    发明授权
    YKL-40 as a marker for gastrointestinal cancers 失效
    YKL-40作为胃肠癌的标志物

    公开(公告)号：US08580520B2

    公开(公告)日：2013-11-12

    申请号：US13063402

    申请日：2009-09-14

    申请人： Julia Sidenius Johansen ,  Nicolai Aagaard Schultz ,  Benny Vittrup Jensen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    发明人： Julia Sidenius Johansen ,  Nicolai Aagaard Schultz ,  Benny Vittrup Jensen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57419 ,  G01N33/57446 ,  G01N2800/52

    摘要： The present invention relates to gastrointestinal cancers and methods for selecting a treatment for said gastrointestinal cancer in a subject. The present invention further relates to a methods of diagnosing the presence of and/or classifying the severity of a gastrointestinal cancer; together with methods for determining the effect of a therapy administered and/or the prognosis for a subject suffering from a gastrointestinal cancer, before, during or after administering the treatment. For all the methods applies that a determined level of YKL-40 above one or more reference levels indicates the treatment, the severity of the disease, the effect of the treatment and/or the prognosis of the subject. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The subject may suffer from any one or more gastrointestinal cancers, such as upper gastrointestinal cancers, and metastatic colorectal cancer. The present invention further relates to a kit and a device that may be used in the method of the present invention.

    摘要翻译： 本发明涉及胃肠癌和用于选择受治疗者中所述胃肠癌的治疗的方法。 本发明还涉及诊断胃肠癌的严重性的存在和/或分类的方法; 以及在施用治疗之前，期间或之后确定施用治疗的效果和/或患有胃肠癌患者的预后的方法。 所有方法都适用于高于一个或多个参考水平的确定水平的YKL-40表示治疗，疾病的严重程度，治疗的效果和/或预后。 参考水平通常是从健康个体获得的水平或以前从相同受试者获得的水平。 受试者可能患有任何一种或多种胃肠癌，例如上消化道癌和转移性结肠直肠癌。 本发明还涉及可用于本发明方法的试剂盒和装置。

    YKL-40 AS A MARKER FOR SELECTION OF TREATMENT AND MONITORING OF A DISEASE
    8.
    发明申请
    YKL-40 AS A MARKER FOR SELECTION OF TREATMENT AND MONITORING OF A DISEASE 审中-公开
    YKL-40作为选择疾病治疗和监测的标志

    公开(公告)号：US20120040355A1

    公开(公告)日：2012-02-16

    申请号：US13063404

    申请日：2009-09-14

    申请人： Julia Sidenius Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    发明人： Julia Sidenius Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    IPC分类号： C12Q1/68 ,  G01N33/577

    CPC分类号： G01N33/6887 ,  G01N33/57419 ,  G01N33/57488 ,  G01N2800/52

    摘要： The present invention relates to a methods for selecting a treatment for a specific disease or disorder, together with a method of monitoring therapeutic treatment of a specific disease or disorder and a method of determining a prognosis for a subject before, during and after administering a treatment by determining the level of YKL-40 in a sample obtained from the subject and comparing said level with one or more reference levels of YKL-40. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The present invention further relates to a kit and a device that may be used in the methods of the present invention.

    摘要翻译： 本发明涉及用于选择特定疾病或病症的治疗的方法以及监测特定疾病或病症的治疗性治疗的方法以及在施用治疗之前，期间和之后确定受试者的预后的方法 通过确定从受试者获得的样品中的YKL-40的水平，并将所述水平与YKL-40的一个或多个参考水平进行比较。 参考水平通常是从健康个体获得的水平或以前从相同受试者获得的水平。 本发明还涉及可用于本发明方法的试剂盒和装置。

    METHODS OF CLASSIFYING THE SEVERITY OF DISEASES OR DISORDERS
    9.
    发明申请
    METHODS OF CLASSIFYING THE SEVERITY OF DISEASES OR DISORDERS 审中-公开
    分类疾病或疾病严重程度的方法

    公开(公告)号：US20120040354A1

    公开(公告)日：2012-02-16

    申请号：US13063391

    申请日：2009-09-14

    申请人： Julia Sidenius Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    发明人： Julia Sidenius Johansen ,  Stig Bojesen ,  Børge Grønne Nordestgaard ,  Hans Jørgen Nielsen ,  Ib Jarle Christensen

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N33/577

    CPC分类号： G01N33/57488 ,  G01N33/57419 ,  G01N33/6887 ,  G01N2800/56

    摘要： The present invention relates to methods of classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 is compared to one or more reference levels of YKL-40, and the severity of said non-specific disease or disorder is deduced from said comparison. The present invention furthermore relates to a method of classifying the severity of a disease or disorder in a subject, wherein a determined level of YKL-40 is compared to one or more previously determined levels of YKL-40 from the same subject. In both methods, the subject may suffer from a variety of diseases or disorders. In addition the present invention relates to a kit and a device that may be used in the methods of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with one or more reference levels of YKL-40.

    摘要翻译： 本发明涉及将受试者中非特异性疾病或病症的严重程度分类的方法，其中将确定水平的YKL-40与一个或多个参考水平的YKL-40进行比较， 从所述比较中推导出特定的疾病或障碍。 本发明还涉及对受试者中疾病或病症的严重程度进行分类的方法，其中将确定水平的YKL-40与来自同一受试者的一种或多种先前确定的YKL-40水平进行比较。 在两种方法中，受试者可能患有各种疾病或病症。 此外，本发明涉及可用于本发明方法的试剂盒和装置，其包括用于测量样品中YKL-40水平的装置; 以及用于将YKL-40的测量水平与YKL-40的一个或多个参考水平进行比较的装置。