公开(公告)号：US08852145B2

公开(公告)日：2014-10-07

申请号：US13884981

申请日：2011-10-27

申请人： Igor Denenburg ,  Nimrod Lev ,  Moshe Gilboa

发明人： Igor Denenburg ,  Nimrod Lev ,  Moshe Gilboa

IPC分类号： A61M37/00 ,  A61M5/32 ,  A61J1/20

CPC分类号： A61M5/3294 ,  A61J1/201 ,  A61J1/2096

摘要： Inline liquid drug medical devices for use with a source of physiological fluid and a medicinal vessel for liquid drug reconstitution and administration purposes. The inline liquid drug medical devices include a housing having a longitudinal device axis, a rotary flow control member and a vial adapter for transposing the flow control member from an initial first flow control position for liquid drug reconstitution purposes to a second flow control position for liquid drug administration purposes. The inline liquid drug medical devices include a syringe port and a drug dispensing port co-axial with the device axis. The rotary flow control member is rotatable about an axis of rotation co-axial with the syringe port and the drug dispensing port.

摘要翻译： 用于生理液体来源的液体药物医疗装置和用于液体药物重建和给药目的的药物容器。 在线液体药物医疗装置包括具有纵向装置轴线的壳体，旋转流量控制构件和用于将流量控制构件从用于液体药物重建目的的初始第一流量控制位置转移到液体的第二流量控制位置的小瓶适配器 药物管理目的。 在线液体药物医疗装置包括与装置轴线同轴的注射器端口和药物分配口。 旋转流量控制构件可以围绕与注射器端口和药物分配端口同轴的旋转轴线旋转。

公开(公告)号：US08070739B2

公开(公告)日：2011-12-06

申请号：US12063176

申请日：2006-08-08

申请人： Freddy Zinger ,  Igor Denenburg ,  Moshe Gilboa

发明人： Freddy Zinger ,  Igor Denenburg ,  Moshe Gilboa

IPC分类号： A61B19/00 ,  A61M5/32

CPC分类号： A61J1/2089 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2096

摘要： Liquid drug transfer devices including a vial adapter designed for failsafe correct snap fitting on a medicinal vial for ensuring flow communication with the vial's interior. The vial adapters include at least two non-adjacent vial retention flex members for snap fitting over a vial opening for vial retention purposes and at least two non-adjacent vial guidance flex members longer than their counterpart vial retention flex members for guiding a vial adapter with respect to a vial prior to snap fitting the vial adapter thereon.

摘要翻译： 液体药物转移装置，包括设计用于故障保护的小瓶适配器，正确地配合在药瓶上，以确保与小瓶内部的流动连通。 小瓶适配器包括至少两个不相邻的小瓶保持柔性构件，用于卡扣配合在小瓶开口上用于小瓶保持目的，并且至少两个不相邻的小瓶引导柔性构件比其对应的小瓶保持柔性构件更长，用于将小瓶适配器引导至 在将小瓶适配器卡在其上之前，相对于小瓶。

公开(公告)号：US20100168664A1

公开(公告)日：2010-07-01

申请号：US12596167

申请日：2008-04-16

申请人： Freddy Zinger ,  Igor Denenburg

发明人： Freddy Zinger ,  Igor Denenburg

IPC分类号： A61M5/31 ,  A61J1/20

CPC分类号： A61J1/2096 ,  A61J1/201 ,  A61J1/2037 ,  A61J1/2058 ,  A61M39/223 ,  A61M2039/229

摘要： Fluid control device (70) including a housing (31) with a syringe port (33) for receiving a syringe, a vial adapter port (36) with a vial adapter (86) for snap fit receiving a vial, and a drug administration port (34) for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The fluid control device additionally includes a manually depressed actuator (74) for sealing pathways which may lead to leakage of liquid drug subsequent to vial adapter detachment, thereby facilitating their use for handling and administration of hazardous liquid drugs. The manually depressed actuator preferably precludes vial adapter detachment prior to actuation, thereby ensuring failsafe operation.

摘要翻译： 流体控制装置（70）包括具有用于接收注射器的注射器端口（33）的壳体（31），具有适于接合小瓶的小瓶适配器（86）的小瓶适配器端口（36）和药物管理端口 （34），用于施用液体药物。 小瓶适配器旨在在混合程序之后旋转分离，以与废样品瓶一起丢弃。 流体控制装置还包括用于密封通路的手动按压致动器（74），其可能导致在小瓶适配器拆卸之后液体药物泄漏，从而便于其用于处理和施用有害液体药物。 手动按压的致动器优选地在致动之前防止小瓶适配器拆卸，从而确保故障安全操作。

公开(公告)号：US06565539B1

公开(公告)日：2003-05-20

申请号：US09936201

申请日：2002-02-12

申请人： Freddy Zinger ,  Igor Denenburg ,  Benny Kutal

发明人： Freddy Zinger ,  Igor Denenburg ,  Benny Kutal

IPC分类号： A61M500

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  B05C17/0136 ,  B05C17/015

摘要： The device for applying a flowable medium, in particular a tissue adhesive is provided with at least one reservoir (16) for the medium, wherein said reservoir (16) comprises an outlet (22) from which the medium exits when pressure is applied to the medium and/or said reservoir (16). A pressure-generating element (20) acts upon the medium and/or said reservoir (16) and is biased by a biasing means (34). Said biasing means (34) can be locked with the aid of a controllable locking means (58), wherein said locking means (58) comprises a movable fixing element (54) which, in at least one fixing position, locks the biasing element (34) against movements caused by the biasing process, and is movable out of the at least one fixing position to release said biasing element (34). Further, a release means (81) for selected release of said locking means (58) is provided, wherein said release means (81) comprises a release element (82) for temporary movement of the fixing element (56) out of its at least one fixing position.

摘要翻译： 用于施加可流动介质，特别是组织粘合剂的装置设置有用于介质的至少一个储存器（16），其中所述储存器（16）包括出口（22），当压力施加到所述出口 介质和/或所述储存器（16）。 压力产生元件（20）作用在介质和/或所述储存器（16）上并由偏置装置（34）偏置。 借助于可控制的锁定装置（58），所述偏压装置（34）可以被锁定，其中所述锁定装置（58）包括可动的固定元件（54），所述可移动固定元件在至少一个固定位置中锁定偏置元件 34）抵抗由偏置过程引起的运动，并且可移动到至少一个固定位置以释放所述偏压元件（34）。 此外，提供了用于所述锁定装置（58）的选择释放的释放装置（81），其中所述释放装置（81）包括释放元件（82），用于将固定元件（56）从其至少 一个固定位置。

公开(公告)号：US06224346B1

公开(公告)日：2001-05-01

申请号：US09370376

申请日：1999-08-09

申请人： Igor Denenburg

发明人： Igor Denenburg

IPC分类号： F04B106

CPC分类号： F04B1/047 ,  F04B1/02 ,  F04B7/0015 ,  F04B7/003

摘要： An apparatus for moving fluid from a first location to a second location comprises a housing containing a pump body having a central passageway with a fluid inlet and first and second fluid outlets in communication with the passageway. A shuttle having first and second fluid chambers is movable within the passageway of the body between first and second positions. First, second, third, and fourth generally annular shaped fluid passageways provided in the shuttle permit selective fluid communication between the first and second fluid chambers of the shuttle and the inlet and outlet ports of the pump body. First and second inlet passageways provided in the shuttle permits selective fluid communication between the inlet of the pump body and the first and second fluid chambers of the shuttle. A piston is reciprocally movable within the shuttle chambers by a uniquely configured operating mechanism, such as a cam ring. The reciprocation piston functions, not only to control fluid flow through the shuttle, but also functions to move the shuttle between its first and second positions within the central passageway of the pump body.

摘要翻译： 用于将流体从第一位置移动到第二位置的装置包括容纳泵体的壳体，所述泵体具有带有流体入口的中心通道以及与通道连通的第一和第二流体出口。 具有第一和第二流体室的梭子可在主体的通道内在第一和第二位置之间移动。 设置在梭中的第一，第二，第三和第四大体呈环形的流体通道允许梭子的第一和第二流体室与泵体的入口和出口之间的选择性流体连通。 设置在梭中的第一和第二入口通道允许在泵体的入口与梭子的第一和第二流体室之间的选择性流体连通。 活塞通过独特构造的操作机构（例如凸轮环）在梭室内可往复运动。 往复活塞不仅用于控制通过梭子的流体流动，还起到使梭子在泵体的中心通道内的第一和第二位置之间移动的功能。

公开(公告)号：US08551067B2

公开(公告)日：2013-10-08

申请号：US12112490

申请日：2008-04-30

申请人： Freddy Zinger ,  Igor Denenburg

发明人： Freddy Zinger ,  Igor Denenburg

IPC分类号： A61M39/22 ,  A61M39/00 ,  A61M39/14 ,  A61M39/16 ,  A61M39/26

CPC分类号： A61J1/20 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1468 ,  A61J1/1487 ,  A61M5/162 ,  A61M39/045 ,  A61M39/26

摘要： A needleless additive control valve for use with a fluid container containing an infusion liquid and having an intravenous (IV) port for administrating the infusion liquid, and an additive transfer device containing a liquid additive and having a male connector for administrating the liquid additive. The needleless additive control valve includes a trifurcated connector body having an IV spike for sealing insertion into the IV port, an outlet port, and a needleless additive port with a female connector for sealingly receiving the additive transfer device's male connector wherein the IV spike, the outlet port and the needleless additive port are in 3 way direct and continuous fluid communication thereby enabling the additive transfer device's liquid additive to be either mixed with the infusion liquid or directly administered to a patient.

摘要翻译： 一种无针添加剂控制阀，其与含有输液的流体容器一起使用并具有用于施用输注液的静脉注射（IV）端口，以及含有液体添加剂的添加剂转移装置，并具有用于施用液体添加剂的阳连接器。 无针添加剂控制阀包括具有用于密封插入IV端口的IV尖端的三叉连接器主体，出口端口和带有用于密封地接收添加剂转移装置的阳连接器的无针式添加剂端口，其中IV尖峰 出口和无针加药口都是三通直接和连续的流体连通，从而使添加剂转移装置的液体添加剂与输注液体混合或直接施用于患者。

公开(公告)号：US08435210B2

公开(公告)日：2013-05-07

申请号：US12596167

申请日：2008-04-16

申请人： Freddy Zinger ,  Igor Denenburg

发明人： Freddy Zinger ,  Igor Denenburg

IPC分类号： A61M37/00

CPC分类号： A61J1/2096 ,  A61J1/201 ,  A61J1/2037 ,  A61J1/2058 ,  A61M39/223 ,  A61M2039/229

摘要： Fluid control device (70) including a housing (31) with a syringe port (33) for receiving a syringe, a vial adapter port (36) with a vial adapter (86) for snap fit receiving a vial, and a drug administration port (34) for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The fluid control device additionally includes a manually depressed actuator (74) for sealing pathways which may lead to leakage of liquid drug subsequent to vial adapter detachment, thereby facilitating their use for handling and administration of hazardous liquid drugs. The manually depressed actuator preferably precludes vial adapter detachment prior to actuation, thereby ensuring failsafe operation.

摘要翻译： 流体控制装置（70）包括具有用于接收注射器的注射器端口（33）的壳体（31），具有适于接合小瓶的小瓶适配器（86）的小瓶适配器端口（36）和药物管理端口 （34），用于施用液体药物。 小瓶适配器旨在在混合程序之后旋转分离，以与废样品瓶一起丢弃。 流体控制装置还包括用于密封通路的手动按压致动器（74），其可能导致在小瓶适配器拆卸之后液体药物泄漏，从而便于其用于处理和施用有害液体药物。 手动按压的致动器优选地在致动之前防止小瓶适配器拆卸，从而确保故障安全操作。

公开(公告)号：US07879018B2

公开(公告)日：2011-02-01

申请号：US11559152

申请日：2006-11-13

申请人： Freddy Zinger ,  Igor Denenburg

发明人： Freddy Zinger ,  Igor Denenburg

IPC分类号： A61B19/00

CPC分类号： A61M39/18 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2058 ,  A61J1/2062 ,  A61J1/2075 ,  A61J1/2082 ,  A61J1/2089 ,  A61J1/2096 ,  A61M5/162 ,  A61M39/223 ,  A61M2039/1077

摘要： A fluid ducting assembly for enabling flow communication between a syringe and either one of a vessel and a dispenser for dispensing a fluid contained, a priori in the syringe or in the vessel. The fluid ducting assembly includes a base having a first member, a second member, and a third member for connection to and providing flow communication with the syringe, the vessel and the dispenser, respectively. The fluid ducting assembly further includes a flow controller within the base enabling any one of a flow path between the first member and the second member and a flow path between the first member and the third member. The flow controller has either a first operative position in which the flow path between the first member and the second member in enabled or a second operative position in which the flow path between the first member and the third member is enabled. The flow controller being readily switchable from its first operative position to its second operative position but not readily switchable form its second operative position to its first operative position.

摘要翻译： 一种流体管道组件，用于使得注射器与容器和分配器中的任一个之间的流动连通，用于分配在注射器或容器中先前包含的流体。 流体管道组件包括具有第一构件，第二构件和第三构件的基座，用于分别连接到注射器，容器和分配器并与其提供流动连通。 所述流体管道组件还包括在所述基座内的流量控制器，其使得所述第一构件和所述第二构件之间的流动路径中的任何一个以及所述第一构件和所述第三构件之间的流动路径。 流量控制器具有第一操作位置，在该第一操作位置中第一构件和第二构件之间的流动路径处于使能状态或第二操作位置，在第二操作位置中第一构件和第三构件之间的流动路径被启用。 流量控制器可以从其第一操作位置容易地切换到其第二操作位置，但是不能容易地切换形成其第二操作位置到其第一操作位置。

公开(公告)号：US20100204679A1

公开(公告)日：2010-08-12

申请号：US12678928

申请日：2008-07-15

申请人： Igor Denenburg

发明人： Igor Denenburg

IPC分类号： A61M5/31

CPC分类号： A61J1/2096 ,  A61J1/201 ,  A61J1/2037 ,  A61J1/2051 ,  A61J1/2055 ,  A61J1/2089

摘要： A mixing and injection apparatus including a needle and a needle base, a syringe attachment element and a mixing chamber engagement assembly including a needle chamber surrounding the needle and a first liquid conduit portion, sealed from the needle chamber and a mixing chamber engagement portion including a second liquid conduit portion communicating with the first liquid conduit portion and configured for communication with a mixing chamber, the syringe attachment element and the needle base being configured to permit liquid communication between an interior of the syringe and the first liquid conduit portion when the syringe attachment element and the needle base are in the first relative engagement orientation and to permit liquid communication between an interior of the syringe and the needle when the syringe attachment element and the needle base are in the second relative engagement orientation, axially separated from the first relative orientation along the injection axis.

摘要翻译： 一种混合注射装置，包括针和针座，注射器安装元件和混合室接合组件，其包括围绕针的针室和从针室密封的第一液体导管部分，以及混合室接合部分， 所述第二液体导管部分与所述第一液体导管部分连通并且构造成用于与混合室连通，所述注射器附接元件和所述针座被构造成当所述注射器附接时注射器的内部与所述第一液体导管部分之间的液体连通 元件和针座处于第一相对接合方向，并且当注射器附接元件和针座处于第二相对接合方向时，允许注射器内部和针之间的液体连通，从而与第一相对取向轴向分离 沿注射轴。

公开(公告)号：US20090177177A1

公开(公告)日：2009-07-09

申请号：US12063176

申请日：2006-08-08

申请人： Freddy Zinger ,  Igor Denenburg ,  Moshe Gilboa

发明人： Freddy Zinger ,  Igor Denenburg ,  Moshe Gilboa

IPC分类号： A61J1/20

CPC分类号： A61J1/2089 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2096

摘要： Liquid drug transfer devices including a vial adapter designed for failsafe correct snap fitting on a medicinal vial for ensuring flow communication with the vial's interior. The vial adapters include at least two non-adjacent vial retention flex members for snap fitting over a vial opening for vial retention purposes and at least two non-adjacent vial guidance flex members longer than their counterpart vial retention flex members for guiding a vial adapter with respect to a vial prior to snap fitting the vial adapter thereon.

摘要翻译： 液体药物转移装置，包括设计用于故障保护的小瓶适配器，正确地配合在药瓶上，以确保与小瓶内部的流动连通。 小瓶适配器包括至少两个不相邻的小瓶保持柔性构件，用于卡扣配合在小瓶开口上用于小瓶保持目的，并且至少两个不相邻的小瓶引导柔性构件比其对应的小瓶保持柔性构件更长，用于将小瓶适配器引导至 在将小瓶适配器卡在其上之前，相对于小瓶。