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    Transcription factors
    2.
    发明授权
    Transcription factors 有权
    转录因子

    公开(公告)号：US08017341B2

    公开(公告)日：2011-09-13

    申请号：US11738355

    申请日：2007-04-20

    申请人： Igor Nikolaev ,  Susan Mampusti Madrid

    发明人： Igor Nikolaev ,  Susan Mampusti Madrid

    IPC分类号： C12Q1/68 ,  C12N15/00 ,  C12N1/15 ,  C07H21/04

    CPC分类号： C07K14/38 ,  C12N15/80 ,  C12N2501/60

    摘要： The present invention relates to an isolated nucleic acid sequence coding for a PntR transcription factor comprising a nucleotide sequence that is the same as, or is complementary to, or contains any suitable codon substitutions for any of those of SEQ ID NOs: 1, 3 or 5 or comprises a sequence which has at least 60% sequence homology with any of SEQ ID NOs: 1, 3 or 5, as well as corresponding polypeptides, vector systems and host cells comprising the same. In particular, the invention relates to sequences which are obtained from an Aspergillus, Trichoderma or Penicillium cell. The invention further relates to methods for disrupting PntR expression in a cell as well as methods for expression or production of a POI in a host cell in which PntR expression has been disrupted.

    摘要翻译： 本发明涉及编码PntR转录因子的分离的核酸序列，所述核酸序列包含与SEQ ID NO：1,3或任何SEQ ID NO：1,3中任一个相同或互补的任何合适的密码子取代的核苷酸序列或 或包含与SEQ ID NO：1,3或5中任一个具有至少60％序列同源性的序列，以及相应的多肽，载体系统和包含该序列的宿主细胞。 特别地，本发明涉及从曲霉属，木霉属或青霉属细胞获得的序列。 本发明还涉及破坏细胞中PntR表达的方法以及在PntR表达被破坏的宿主细胞中表达或产生POI的方法。

    Transcription Factors
    3.
    发明申请
    Transcription Factors 有权
    转录因子

    公开(公告)号：US20070254336A1

    公开(公告)日：2007-11-01

    申请号：US11738355

    申请日：2007-04-20

    申请人： Igor Nikolaev ,  Susan Madrid

    发明人： Igor Nikolaev ,  Susan Madrid

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/24 ,  C12N15/74 ,  C12N1/16

    CPC分类号： C07K14/38 ,  C12N15/80 ,  C12N2501/60

    摘要： The present invention relates to an isolated nucleic acid sequence coding for a PntR transcription factor comprising a nucleotide sequence that is the same as, or is complementary to, or contains any suitable codon substitutions for any of those of SEQ ID NOs: 1, 3 or 5 or comprises a sequence which has at least 60% sequence homology with any of SEQ ID NOs: 1, 3 or 5, as well as corresponding polypeptides, vector systems and host cells comprising the same. In particular, the invention relates to sequences which are obtained from an Aspergillus, Trichoderma or Penicillium cell. The invention further relates to methods for disrupting PntR expression in a cell as well as methods for expression or production of a POI in a host cell in which PntR expression has been disrupted.

    摘要翻译： 本发明涉及编码PntR转录因子的分离的核酸序列，所述核酸序列包含与SEQ ID NO：1,3或任何SEQ ID NO：1,3中任一个相同或互补的任何合适的密码子取代的核苷酸序列或 或包含与SEQ ID NO：1,3或5中任一个具有至少60％序列同源性的序列，以及相应的多肽，载体系统和包含该序列的宿主细胞。 特别地，本发明涉及从曲霉属，木霉属或青霉属细胞获得的序列。 本发明还涉及破坏细胞中PntR表达的方法以及在PntR表达被破坏的宿主细胞中表达或产生POI的方法。

    METHOD AND SYSTEM FOR ALLOCATION OF RESOURCES IN AN AGILE ENVIRONMENT
    6.
    发明申请
    METHOD AND SYSTEM FOR ALLOCATION OF RESOURCES IN AN AGILE ENVIRONMENT 审中-公开
    方法和系统分配资源在AGILE环境

    公开(公告)号：US20130090971A1

    公开(公告)日：2013-04-11

    申请号：US13270773

    申请日：2011-10-11

    申请人： Sean Morris ,  Keith Kroeger ,  Thomas McGuire ,  Igor Nikolaev

    发明人： Sean Morris ,  Keith Kroeger ,  Thomas McGuire ,  Igor Nikolaev

    IPC分类号： G06Q10/06

    CPC分类号： G06Q10/06

    摘要： A computer-implemented method is provided for optimizing allocation of resources across stories for a release within an Agile development environment. The method includes receiving (i) resource information representing a plurality of resources available for allocation to the stories, (ii) one or more story definitions, each story definition comprising a unique identifier and one or more story-level constraints corresponding to a story, (iii) release information, (iv) iteration information, and (iv) one or more optimization criteria. The method also includes generating a plurality of story-level allocation scenarios and determining one or more optimized story-level allocation scenarios from the plurality of story-level allocation scenarios. Each story-level allocation scenario satisfies the one or more story-level constraints associated with each story definition. Each optimized story-level allocation scenario optimizes assignment of iterations or allocation of resources to the stories to satisfy the one or more optimization criteria.

    摘要翻译： 提供了一种计算机实现的方法，用于优化跨敏捷开发环境中发布的故障资源分配。 该方法包括接收（i）表示可用于分配给故事的多个资源的资源信息，（ii）一个或多个故事定义，每个故事定义包括唯一标识符和与故事相对应的一个或多个故事级约束， （iii）发布信息，（iv）迭代信息，和（iv）一个或多个优化标准。 该方法还包括生成多个故事层级分配场景并且从多个故事层级分配场景中确定一个或多个优化的故事级分配场景。 每个故事级分配方案满足与每个故事定义相关联的一个或多个故事级限制。 每个优化的故事级别分配情景优化了迭代的分配或资源分配到故事以满足一个或多个优化标准。

    Method and system for allocation of resources in a project portfolio
    8.
    发明授权
    Method and system for allocation of resources in a project portfolio 有权
    项目组合中资源分配的方法和系统

    公开(公告)号：US07991632B1

    公开(公告)日：2011-08-02

    申请号：US13016551

    申请日：2011-01-28

    申请人： Sean Morris ,  Keith Kroeger ,  Thomas McGuire ,  Igor Nikolaev

    发明人： Sean Morris ,  Keith Kroeger ,  Thomas McGuire ,  Igor Nikolaev

    IPC分类号： G06Q10/00

    CPC分类号： G06Q10/06 ,  G06Q10/063 ,  G06Q10/0631 ,  G06Q10/06311 ,  G06Q10/063112 ,  G06Q10/06313 ,  G06Q30/0206

    摘要： Described are methods and apparatuses, including computer program products, for optimizing allocation of resources across projects in a project portfolio. The method includes receiving, at a computing device, (i) resource information, (ii) a portfolio of project definitions and (iii) one or more portfolio-level optimization criteria. The resource information representing a plurality of resources available for allocation to the projects, and each project definition includes a unique identifier and one or more project-level constraints. The method also includes generating, using the computing device, a plurality of project portfolio allocation scenarios and determining one or more optimized project portfolio allocation scenarios from the plurality of project portfolio allocation scenarios. Each project portfolio allocation scenario satisfies the one or more project-level constraints associated with each project definition. Each optimized project portfolio allocation scenario optimizes a sequence of the projects to satisfy the one or more portfolio-level optimization criteria.

    摘要翻译： 描述了一些方法和设备，包括计算机程序产品，用于优化项目组合中项目的资源分配。 该方法包括在计算设备处接收（i）资源信息，（ii）项目定义组合和（iii）一个或多个组合级优化标准。 表示可用于分配给项目的多个资源的资源信息，并且每个项目定义包括唯一标识符和一个或多个项目级约束。 该方法还包括使用计算设备生成多个项目组合分配场景，并从多个项目组合分配场景中确定一个或多个优化的项目组合分配情景。 每个项目组合分配方案满足与每个项目定义相关联的一个或多个项目级约束。 每个优化的项目组合分配情景优化了一系列项目，以满足一个或多个组合级优化标准。