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公开(公告)号：US20230137106A1
公开(公告)日：2023-05-04
申请号：US18089352
申请日：2022-12-27
IPC分类号： C12Q1/6874 , C12N15/10
摘要： The present disclosure is concerned with compositions and methods for the paired-end sequencing of target nucleic acids, and more particularly to obtaining nucleotide sequence information from two separate regions of target nucleic acids using amplification sites having a single type of surface primer.
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公开(公告)号：US20230102870A1
公开(公告)日：2023-03-30
申请号：US17934394
申请日：2022-09-22
IPC分类号： C08G77/445
摘要： Some of the resin compositions are ultraviolet light or thermally curable, while others are ultraviolet light curable. One example of the ultraviolet light or thermally curable resin composition consists of a predetermined mass ratio of a (meth)acrylate cyclosiloxane monomer and a non-siloxane (meth)acrylate based monomer ranging from about >0:
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公开(公告)号：US20230098456A1
公开(公告)日：2023-03-30
申请号：US17994541
申请日：2022-11-28
IPC分类号： C12Q1/6869
摘要： The invention relates to methods for pairwise sequencing of a polynucleotide template which result in the sequential determination of nucleotide sequence in two distinct and separate regions of the polynucleotide template.
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公开(公告)号：US20230086755A1
公开(公告)日：2023-03-23
申请号：US17932709
申请日：2022-09-16
发明人： Jessica WALSH , Sébastien RICOULT , Yin Nah TEO , Simon BAKER
IPC分类号： C12Q1/6869 , C12Q1/6806
摘要： The present disclosure relates to compositions including a shell surrounding an interior compartment, wherein said interior compartment comprises one or more reagent and wherein said shell releases said interior compartment when said shell is exposed to a first release condition, wherein said interior compartment releases said one or more reagent when said interior compartment is exposed to a second release condition, and wherein said first release condition is different from said second release condition. Also disclosed are compositions including a dissolvable first shell, and a dissolvable second shell, the second shell comprising one or more reagent. Also disclosed are methods for controlling release of one or more reagent using the compositions described herein. The present disclosure further relates to cartridges that include a reagent reservoir including the compositions described herein. Also disclosed are systems for controlling release of one or more reagent including the compositions described herein.
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公开(公告)号：US20230055284A1
公开(公告)日：2023-02-23
申请号：US17867018
申请日：2022-07-18
发明人： Wayne N. George , Andrew A. Brown
IPC分类号： C12Q1/6869
摘要： Embodiments of the present disclosure relate to nucleotides labeled with photoswitchable compounds. Also provided herein are methods and kits of using these labeled nucleotides for sequencing applications.
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公开(公告)号：USRE49362E1
公开(公告)日：2023-01-10
申请号：US16917713
申请日：2020-06-30
摘要： Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a variety of applications, such as in assays involving staining of cells, protein binding, and analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
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公开(公告)号：US20220411864A1
公开(公告)日：2022-12-29
申请号：US17808161
申请日：2022-06-22
发明人： Yin Nah TEO , Karen GOH , Dorry POA , Oliver MILLER , Sergio PEISAJOVICH , Trina OSOTHPRAROP , Youna RO , Sébastien RICOULT , Dale WEEKES
IPC分类号： C12Q1/6869
摘要： The present disclosure relates to a composition including one or more modified nucleotide, wherein the modified nucleotide comprises a purine or pyrimidine base and a sugar moiety having a 3′-hydroxy blocking group, and a radical scavenger, wherein the composition is lyophilised. The present disclosure further relates to a composition including one or more functional protein; one or more functional protein activator; and one or more non-reducing sugar, wherein the composition is lyophilised. Also disclosed are methods of rehydration of one or more compositions described herein and kits including one or more compositions described herein. Further disclosed are cartridges including a flow cell comprising one or more reagent reservoirs, where the one or more reagent reservoirs include one or more compositions described herein.
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公开(公告)号：US20220403376A1
公开(公告)日：2022-12-22
申请号：US17890632
申请日：2022-08-18
IPC分类号： C12N15/10 , C12N9/22 , C12Q1/6806 , C40B50/14
摘要： Presented herein are methods and compositions surface-based tagmentation. In particular embodiments, methods of preparing an immobilized library of fragmented and tagged DNA molecules on a solid surface are presented. In particular embodiments, the solid surface comprises immobilized transposomes in a dried format, suitable for reconstitution upon contact with liquid, such as a liquid sample.
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公开(公告)号：US20220220553A1
公开(公告)日：2022-07-14
申请号：US17708498
申请日：2022-03-30
发明人： Antoine FRANCAIS , Elena CRESSINA , Adam CULLEY , Angelica MARIANI , Xiaolin WU , Xiaohai LIU
IPC分类号： C12Q1/6869 , C07H19/06 , C07H19/16 , C07H21/00
摘要： Embodiments of the present disclosure relate to nucleotide molecules with a 3′ AOM blocking group. Also provided herein are methods to prepare such nucleotide molecules, and the uses of fully functionalized nucleotides containing the 3′-OH blocking group for sequencing applications.
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公开(公告)号：US11371078B2
公开(公告)日：2022-06-28
申请号：US17162606
申请日：2021-01-29
IPC分类号： C12Q1/6816 , C07D491/04 , C07D491/052 , C07D491/147 , C07H19/10 , C07H19/14 , C07H21/00 , C09K11/06 , C12Q1/6869 , C12Q1/6876
摘要： The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
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