公开(公告)号：US20220081427A1

公开(公告)日：2022-03-17

申请号：US17523949

申请日：2021-11-11

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/433 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20190330315A1

公开(公告)日：2019-10-31

申请号：US16092055

申请日：2017-04-05

申请人： Imago Pharmaceuticals, Inc.

发明人： Irene Griswold-Prenner ,  Karen Chen

IPC分类号： C07K16/18 ,  A61P25/00

摘要： The invention provides therapeutic antibodies and methods for treatment of diseases associated with diseases associated with aggregation of α-synuclein, e.g., in the brain of a subject. Such methods provide administration of therapeutic antibodies to elicit a beneficial immunogenic response against aggregation of α-synuclein. The methods are particularly useful for prophylactic and therapeutic treatment of diseases associated with the formation of Lewy bodies, e.g., Parkinson's disease.

公开(公告)号：US20190231751A1

公开(公告)日：2019-08-01

申请号：US16332334

申请日：2017-09-11

申请人： Imago Pharmaceuticals, Inc.

发明人： Irene Griswold-Prenner ,  Karen Chen

IPC分类号： A61K31/4196 ,  A61K31/4192 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/4178 ,  A61K31/4375 ,  A61K31/519 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/5377 ,  A61P1/16 ,  A61P11/00 ,  A61P19/04

CPC分类号： A61K31/4196 ,  A61K31/381 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/519 ,  A61K31/5377 ,  A61P1/16 ,  A61P11/00 ,  A61P19/04

摘要： The present disclosure provides a method of treating diseases, conditions or disorders associated with fibrosis in a mammal using inhibitors of the Jun N-terminal kinase (JNK) pathway. The present disclosure in particular provides methods of treating diseases, conditions or disorders associated with fibrosis using a specific class of small molecule JNK inhibitors.

公开(公告)号：US20190194176A1

公开(公告)日：2019-06-27

申请号：US16288276

申请日：2019-02-28

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/519 ,  A61K31/381 ,  A61K31/498 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/401 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D417/04 ,  C07D413/14 ,  C07D413/04 ,  C07D409/14 ,  A61K31/433 ,  A61K31/4985

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20200039972A1

公开(公告)日：2020-02-06

申请号：US16653110

申请日：2019-10-15

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/433 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20170107209A1

公开(公告)日：2017-04-20

申请号：US15391645

申请日：2016-12-27

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. Hom ,  Andrei W. Konradi ,  Gary D. Probst ,  Simeon Bowers ,  Anh Truong ,  R. Jeffrey Neitz ,  Jennifer Sealy ,  Gregely Toth

IPC分类号： C07D409/04 ,  C07D487/04 ,  C07D413/14 ,  C07D417/14 ,  C07D417/04 ,  C07D413/04 ,  C07D409/14 ,  C07D471/04

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20150259330A1

公开(公告)日：2015-09-17

申请号：US14725691

申请日：2015-05-29

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/14 ,  C07D487/04 ,  C07D409/04

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

摘要翻译： 本公开提供了具有下式结构的c-Jun N-末端激酶（JNK）抑制剂：其盐或溶剂合物，其中环A，Ca，Cb，Z，R 5，W和Cy在本文中定义 。 本公开进一步提供药物组合物，包括本公开的化合物和制备和使用本公开的化合物和组合物的方法，例如治疗和预防各种疾病，例如阿尔茨海默病。

公开(公告)号：US20200277285A1

公开(公告)日：2020-09-03

申请号：US15930067

申请日：2020-05-12

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRADI ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/433 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20180319780A1

公开(公告)日：2018-11-08

申请号：US16039441

申请日：2018-07-19

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Hing L. SHAM ,  Roy K. HOM ,  Andrei W. KONRAD! ,  Gary D. PROBST ,  Simeon BOWERS ,  Anh TRUONG ,  R. Jeffrey NEITZ ,  Jennifer SEALY ,  Gergely TOTH

IPC分类号： C07D409/04 ,  A61K31/519 ,  A61K31/381 ,  A61K31/498 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/401 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D417/04 ,  C07D413/14 ,  C07D413/04 ,  C07D409/14 ,  A61K31/433 ,  A61K31/4985

CPC分类号： C07D409/04 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/519 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

公开(公告)号：US20180258083A1

公开(公告)日：2018-09-13

申请号：US15459008

申请日：2017-03-15

申请人： IMAGO PHARMACEUTICALS, INC.

发明人： Albert GAROFALO ,  Danielle AUBELE

IPC分类号： C07D417/12

CPC分类号： C07D417/12

摘要： A compound having a structure according to Formula (I): or a salt thereof, pharmaceutical compositions including a compound of formula (I), methods of making and using the compounds and compositions including a compound of formula (I), for example, in the treatment and prevention of various disorders, such as Parkinson's disease.