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公开(公告)号：US06984395B2
公开(公告)日：2006-01-10
申请号：US09833406
申请日：2001-04-11
IPC分类号： A61K9/127
CPC分类号： A61K9/19 , A61K9/1075 , A61K9/127 , A61K41/0038 , A61K41/0057 , A61K41/0071 , Y10S514/937
摘要： Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.
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公开(公告)号：US20060039965A1
公开(公告)日：2006-02-23
申请号：US11254400
申请日：2005-10-20
申请人： Ronald Boch , Dev Mitra Singh , Iman Karmadi
发明人： Ronald Boch , Dev Mitra Singh , Iman Karmadi
IPC分类号： A61K9/127 , A61K31/555 , A61K31/409
CPC分类号： A61K9/19 , A61K9/1075 , A61K9/127 , A61K41/0038 , A61K41/0057 , A61K41/0071 , Y10S514/937
摘要： Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favo the production of small aggregates for improved filter sterilization.
摘要翻译： 描述了包含含有疏水性药物的微团聚体的组合物及其生产方法。 这种微团聚体可以包括胶束结构或其与脂质体的组合，并且构成疏水剂的有效递送载体。 微团聚体生产的方法包括使用优选的脂质化合物和加工条件，以生产小聚集体以改进过滤器灭菌。
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公开(公告)号：US08852629B2
公开(公告)日：2014-10-07
申请号：US12487964
申请日：2009-06-19
CPC分类号： A61K9/19 , A61K9/1075 , A61K9/127 , A61K41/0038 , A61K41/0057 , A61K41/0071 , Y10S514/937
摘要： Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.
摘要翻译： 描述了包含含有疏水性药物的微团聚体的组合物及其生产方法。 这种微团聚体可以包括胶束结构或其与脂质体的组合，并且构成疏水剂的有效递送载体。 用于微团聚体生产的方法包括使用优选的脂质化合物和有利于生产小聚集体以改进过滤器灭菌的加工条件。
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公开(公告)号：US20100247447A1
公开(公告)日：2010-09-30
申请号：US12487964
申请日：2009-06-19
IPC分类号： A61K31/409 , A61K9/50 , A61K49/00 , A61P35/00 , A61P27/02 , A61P31/12 , A61P31/00 , A61P9/10
CPC分类号： A61K9/19 , A61K9/1075 , A61K9/127 , A61K41/0038 , A61K41/0057 , A61K41/0071 , Y10S514/937
摘要： Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.
摘要翻译： 描述了包含含有疏水性药物的微团聚体的组合物及其生产方法。 这种微团聚体可以包括胶束结构或其与脂质体的组合，并且构成疏水剂的有效递送载体。 用于微团聚体生产的方法包括使用优选的脂质化合物和有利于生产小聚集体以改进过滤器灭菌的加工条件。
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