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公开(公告)号:US20230097413A1
公开(公告)日:2023-03-30
申请号:US17701884
申请日:2022-03-23
申请人: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PARIS DESCARTES , Sorbonne Universite , Universite Paris Diderot - Paris 7 , Fondation Asile des Aveugles
发明人: Francine BEHAR-COHEN , Min ZHAO
IPC分类号: A61K31/585 , A61K45/06 , A61P27/02 , A61K9/00 , A61K9/16
摘要: The present invention relates to methods and pharmaceutical compositions for the treatment of choroddal neovascularisation. In particular, the present invention relates to a method of treating choroidial neovascularisation in a subject in need thereof comprising administering to the subject of therapeutically effective amount of a mineralocorticoid receptor antagonist.
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公开(公告)号:US20230088717A1
公开(公告)日:2023-03-23
申请号:US17791851
申请日:2021-01-08
申请人: NANTES UNIVERSITÉ , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人: Didier DUBREUIL , Allan PATINEC , Muriel PIPELIER , Jacques LE PENDU , Jacques LEBRETON , Virginie BLOT , Arnaud TESSIER
摘要: The present invention relates to a new family of iNKT stimulators, referred to as 6″-O-PEGm-NHR-GalCer, which are potent analogues of KRN7000. These iNKT stimulators can advantageously be used in therapy, in particular for the prevention and/or treatment of many diseases requiring a stimulation of an immune response, such as cancer, viral, bacterial or parasitic diseases, autoimmune diseases or inflammatory diseases. The iNKT cell stimulator of the invention may be coupled to a biological carrier, such as a therapeutic and/or targeting agent, or be vectorized, for example in nanoparticles, to be specifically delivered to target cells.
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公开(公告)号:US11609124B2
公开(公告)日:2023-03-21
申请号:US17487313
申请日:2021-09-28
申请人: UNIVERSITE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SORBONNE UNIVERSITE
发明人: Marc Guillon , Gilles Tessier , Tengfei Wu , Pascal Berto
摘要: A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation Δαij defined by Δαij=arccos, where “·” stands for the inner product between and .
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公开(公告)号:US11576371B2
公开(公告)日:2023-02-14
申请号:US16622066
申请日:2018-06-12
申请人: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SORBONNE UNIVERSITE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
摘要: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.
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公开(公告)号:US20230032690A1
公开(公告)日:2023-02-02
申请号:US17818481
申请日:2022-08-09
申请人: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE LILLE , CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
发明人: Luc BUEE , Malika HAMDANE , David BLUM , Maxime DERISBOURG , Coline LEGHAY , Giovanni CHIAPPETTA , Joelle VINH , Yann VERDIER
摘要: The invention relates to the identification of a new Tau species starting at residue Met11 (Met11-Tau) which is N-alpha-terminally acetylated form (N-alpha-acetyl-Met11-Tau species: Ac-Met11-Tau). Several monoclonal antibodies specific of this new Tau species have been developed. One of this antibody, 2H2/D11, was used in THY-Tau22 mouse model (that develops with age neurofibrillary degeneration (NFD) and memory deficits), and N-alpha-Ac-Met11-Tau species were clearly detected early in neurons displaying NFD on hippocampal brain sections while it is not reactive in hippocampus from elderly controls. Finally, by using ELISA sandwich specific of Ac-Met11-Tau species, Alzheimer Disease (AD) brain samples are clearly discriminated from human elderly control brains. Thus the invention relates to this new Tau species starting from the methionine residue at position 11 said methionine being N-alpha acetylated. The invention also relates to antibody that specifically binds this new tau species, a method of detection of this new Tau species and a method of diagnosis of Tauopathy disorder.
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公开(公告)号:US11565136B2
公开(公告)日:2023-01-31
申请号:US15508193
申请日:2015-09-01
申请人: UNIVERSITE DE BORDEAUX , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX
发明人: Fabrice Marquet , Pierre Bour , Bruno Quesson , Fanny Vaillant
IPC分类号: A61B5/00 , A61B5/055 , A61B8/00 , A61B8/08 , A61B90/00 , A61N7/02 , A61B34/10 , A61B18/00 , A61B17/00 , A61B6/00 , A61B5/318
摘要: A system for ablating or monitoring a zone of the heart, includes a system to measure the heart electrical activity; a phased array for generating a beam of focussed ultrasound signals on a targeted zone of the heart; an imaging system determining an image of a transcostal wall projected in an image plane of the phased array by taking into consideration a position and direction of the phased array and making it possible to deactivate elements of the phased array in accordance with the position of the elements with regard to the position of the projected image of the transcostal wall; a positioning system to control the position of a focussed zone of a beam of focussed ultrasound signals on the targeted zone, a monitoring system to measure a temperature and tissue deformation in the targeted zone; and a device for measuring a level of cavitation in the targeted zone.
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公开(公告)号:US11559566B2
公开(公告)日:2023-01-24
申请号:US16925983
申请日:2020-07-10
申请人: INSERM (Institut National de la Sante et de la Recherche Medicale) , ASSISTANCE PUBLIQUE HOPITAUX DE PARIS , SORBONNE UNIVERSITE
发明人: David Klatzmann , David Saadoun , Patrice Cacoub , Michèle Rosenzwajg , Eliane Piaggio , Gilbert Bensimon , Claude Bernard
IPC分类号: A61K38/20
摘要: The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use of low dose interleukin-2 for the treatment of type I diabetes and other autoimmune and/or inflammatory diseases.
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公开(公告)号:US11554386B2
公开(公告)日:2023-01-17
申请号:US16095304
申请日:2017-04-21
申请人: CARDIAWAVE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
发明人: Mathieu Pernot , Michael Vion , Mickael Tanter
摘要: An ultrasound imaging and therapy device includes an array of concentric annular ultrasound transducers, and an ultrasound imaging device situated inside an innermost transducer of the plurality of concentric annular ultrasound transducers, wherein it further comprises a mechanical linkage allowing a tilting movement of the array of concentric annular ultrasound transducers with respect to the ultrasound imaging device and in that the ultrasound imaging device protrudes in an axial direction from the array of concentric annular ultrasound transducers; whereby the ultrasound imaging device can be kept stationary and in direct or indirect contact with a patient's skin while the array of concentric annular ultrasound transducers is tilted so as to move a focal point of ultrasound waves generated by the concentric annular ultrasound transducers within an imaging region of the ultrasound imaging device.
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公开(公告)号:US11510896B2
公开(公告)日:2022-11-29
申请号:US16340346
申请日:2017-10-20
申请人: UNIVERSITE CLAUDE BERNARD LYON 1 , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号: A61K31/353 , A61P31/14 , A61K9/00 , A61K31/35 , A61K31/4375 , A61K31/7056 , A61K38/21 , A61K31/351 , A61K31/352 , A61K45/06
摘要: The present invention relates to a pharmaceutical or veterinary composition for its use in preventing and/or treating a MERS-CoV (Middle-East Respiratory Syndrome) coronavirus infection, characterised in that it comprises, in a suitable pharmaceutical vehicle, at least one compound chosen from apigenin and berberine.
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公开(公告)号:US20220361896A1
公开(公告)日:2022-11-17
申请号:US17661719
申请日:2022-05-02
申请人: SpineGuard , Sorbonne Universite , Centre National de la Recherche Scientifique - CNRS , INSERM (Institut National de la Sante et de la Recherche Medicale)
摘要: A medical device for penetrating a bone structure including a processing unit having a transfer function that associates an electrical conductivity value S with a depth value d, wherein the processing unit is configured to detect a threshold selected from amongst an absolute threshold, a relative threshold and a critical gradient, and to emit a warning signal and/or control signal responsive to detection of the threshold.
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