专利检索 ap:"Isabelle Noëlle Constance Pilatte" 第 1 页

1.

发明授权
Inhibitors of histone deacetylase 有权
标题翻译：组蛋白脱乙酰酶抑制剂

公开(公告)号：US08343988B2

公开(公告)日：2013-01-01

申请号：US12372785

申请日：2009-02-18

申请人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin

发明人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin

IPC分类号： A01N43/54 , A61K31/505 , C07D401/00

CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48

摘要： This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括其中n，t，R 1，R 2，R 3，R 4，L，Q，X，Y，Z并具有定义的具有组蛋白脱乙酰酶抑制酶活性的式（I）化合物。其制剂，含有它们的组合物及其作为药物的用途。

2.

发明授权
Aminophenyl derivatives as novel inhibitors of histone deacetylase 有权
标题翻译：氨基苯基衍生物作为组蛋白脱乙酰酶的新型抑制剂

公开(公告)号：US08119650B2

公开(公告)日：2012-02-21

申请号：US12160140

申请日：2007-01-16

申请人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Bruno Roux , Janine Arts

发明人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Bruno Roux , Janine Arts

IPC分类号： C07D401/14 , A61K31/4439

CPC分类号： C07D401/14 , C07D405/14 , C07D409/14

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，X和Y具有定义含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

3.

发明授权
Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase 有权

公开(公告)号：US08592441B2

公开(公告)日：2013-11-26

申请号：US13447636

申请日：2012-04-16

申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen

发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen

IPC分类号： C07D401/14 , C07D409/14 , A61K31/506

CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

4.

发明申请
QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS 有权
标题翻译：喹诺酮衍生物作为PARP和油墨抑制剂

公开(公告)号：US20130018017A1

公开(公告)日：2013-01-17

申请号：US13617686

申请日：2012-09-14

申请人： Jorge Eduardo VIALARD , Patrick René ANGIBAUD , Laurence Anne MEVELLEC , Christophe MEYER , Eddy Jean Edgard FREYNE , Isabelle Noëlle Constance PILATTE , Bruno ROUX , Elizabeth Thérèse Jeanne PASQUIER , Xavier Marc BOURDREZ , Christophe Denis ADELINET , Laurence Françoise Bernadette MARCONNET-DECRANE , Jacqueline Anne MACRITCHIE , James Edward Stewart DUFFY , Andrew Pate OWENS , Pierre-Henri STORCK , Virginie Sophie PONCELET

发明人： Jorge Eduardo VIALARD , Patrick René ANGIBAUD , Laurence Anne MEVELLEC , Christophe MEYER , Eddy Jean Edgard FREYNE , Isabelle Noëlle Constance PILATTE , Bruno ROUX , Elizabeth Thérèse Jeanne PASQUIER , Xavier Marc BOURDREZ , Christophe Denis ADELINET , Laurence Françoise Bernadette MARCONNET-DECRANE , Jacqueline Anne MACRITCHIE , James Edward Stewart DUFFY , Andrew Pate OWENS , Pierre-Henri STORCK , Virginie Sophie PONCELET

IPC分类号： A61K31/4704 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/675 , A61K31/4709 , A61K31/501 , A61K31/475 , A61P25/00 , A61P25/28 , A61P9/00 , A61P21/00 , A61P29/00 , A61P19/06 , A61P19/02 , A61P9/10 , A61P37/00 , A61P35/00 , A61P1/00 , A61P19/10 , A61P3/10 , A61P13/12 , A61K31/695

CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06

摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.

摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有定义含义。

5.

发明申请
SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译：取代的吲哚基氨基酸衍生物作为HISTONE脱乙酰基酶的新型抑制剂

公开(公告)号：US20120220615A1

公开(公告)日：2012-08-30

申请号：US13447636

申请日：2012-04-16

申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen

发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen

IPC分类号： C07D401/14 , A61P35/04 , C07D491/04 , A61K31/506

CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

6.

发明授权
Sulfonylamino-derivatives as novel inhibitors of histone deacetylase 有权
标题翻译：磺酰氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂

公开(公告)号：US08163733B2

公开(公告)日：2012-04-24

申请号：US12724273

申请日：2010-03-15

申请人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden

发明人： Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden

IPC分类号： A61K31/55 , A61K31/4468 , A61K31/506 , A61K31/496

CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48

摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括其中n，m，t，R 1，R 2，R 3，R 4，R 5，L，Q，X，Y，Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式（I）其制剂，含有它们的组合物及其作为药物的用途。

7.

发明授权
Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase 有权
标题翻译：取代的吲哚基 - 烷基 - 氨基衍生物作为组蛋白脱乙酰酶的抑制剂

公开(公告)号：US07834025B2

公开(公告)日：2010-11-16

申请号：US12160221

申请日：2007-01-16

申请人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte

发明人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte

IPC分类号： A61K31/506 , C07D401/14

CPC分类号： C07D401/14

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, R5, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括具有组蛋白脱乙酰酶抑制酶活性的式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，X和Y具有定义的含义; 其制剂，含有它们的组合物及其作为药物的用途。