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    Process for preparing simvastatin having controlled ranges of simvastatin dimer content
    1.
    发明申请
    Process for preparing simvastatin having controlled ranges of simvastatin dimer content 审中-公开
    制备具有辛伐他汀二聚体含量受控范围的辛伐他汀的方法

    公开(公告)号：US20060041148A1

    公开(公告)日：2006-02-23

    申请号：US11255304

    申请日：2005-10-20

    申请人： Ferenc Korodi ,  Csaba Szabo ,  Szabolcs Salyi ,  Istvan Bodi

    发明人： Ferenc Korodi ,  Csaba Szabo ,  Szabolcs Salyi ,  Istvan Bodi

    IPC分类号： C07D309/30

    CPC分类号： C07D309/30

    摘要： The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4 % wt. The present invention also relates to a process for preparing simvastatin having a simvastatin dimer content of less than about 0.2% wt. The present invention also discloses a commercial scale process of preparing simvastatin having a specified simvastatin dimer content which is reproducible.

    摘要翻译： 本发明涉及一种辛伐他汀的制备方法，其中辛伐他汀二聚体含量受到控制。 更具体地，本发明涉及制备辛伐他汀二聚体含量为约0.2至约0.4重量％的辛伐他汀的方法。 本发明还涉及制备辛伐他汀二聚体含量小于约0.2重量％的辛伐他汀的方法。 本发明还公开了制备具有可重现的特定辛伐他汀二聚体含量的辛伐他汀的商业规模的方法。

    High voltage source providing continuously regulated output voltage, preferably for supplying low-power ion and electron beam machining and evaporating apparatuses
    2.
    发明授权
    High voltage source providing continuously regulated output voltage, preferably for supplying low-power ion and electron beam machining and evaporating apparatuses 失效
    高电压源提供连续调节的输出电压，优选用于供应低功率离子和电子束加工和蒸发装置

    公开(公告)号：US4739463A

    公开(公告)日：1988-04-19

    申请号：US943382

    申请日：1986-12-17

    申请人： Arpad Barna ,  Istvan Bodi

    发明人： Arpad Barna ,  Istvan Bodi

    IPC分类号： H01J37/248 ,  H02M3/28 ,  H02M3/337 ,  H02M3/335

    CPC分类号： H02M3/28

    摘要： The invention relates to a stabilized high voltage source the output voltage of which may be regulated in wide range, whereby the adjusted output current is constant at variable load. The high voltage supply source comprises a high voltage rectifier fed by a push-pull driving circuit, a control circuit supplying push-pull width modulated control signals of the driving circuit and an error signal processing circuit working up the divided voltage and current signals taken from the output of the high voltage source. The output signal of the error signal processing circuit is applied to the control circuit as a control signal. The supply voltage of auxiliary circuits of the supply source is provided by a stabilized low voltage supply unit.

    摘要翻译： 本发明涉及一种稳定的高压源，其输出电压可以在宽范围内调节，由此调整的输出电流在可变负载下是恒定的。 高压电源包括由推挽驱动电路馈送的高压整流器，提供驱动电路的推挽宽度调制控制信号的控制电路和处理分离的电压和电流信号的误差信号处理电路 输出高电压源。 误差信号处理电路的输出信号作为控制信号施加到控制电路。 供电源的辅助电路的电源电压由稳定的低压电源单元提供。

    Process for preparing simvastatin having controlled ranges of simvastatin dimer content
    4.
    发明授权
    Process for preparing simvastatin having controlled ranges of simvastatin dimer content 失效
    制备具有辛伐他汀二聚体含量受控范围的辛伐他汀的方法

    公开(公告)号：US06995277B2

    公开(公告)日：2006-02-07

    申请号：US10777535

    申请日：2004-02-11

    申请人： Ferenc Korodi ,  Csaba Szabo ,  Szabolcs Salyi ,  Istvan Bodi

    发明人： Ferenc Korodi ,  Csaba Szabo ,  Szabolcs Salyi ,  Istvan Bodi

    IPC分类号： C07D309/30

    CPC分类号： C07D309/30

    摘要： The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4% wt. The present invention also relates to a process for preparing simvastatin having a simvastatin dimer content of less than about 0.2% wt. The present invention also discloses a commercial scale process of preparing simvastatin having a specified simvastatin dimer content which is reproducible.

    摘要翻译： 本发明涉及一种辛伐他汀的制备方法，其中辛伐他汀二聚体含量受到控制。 更具体地，本发明涉及制备辛伐他汀二聚体含量为约0.2至约0.4重量％的辛伐他汀的方法。 本发明还涉及制备辛伐他汀二聚体含量小于约0.2重量％的辛伐他汀的方法。 本发明还公开了制备具有可重现的特定辛伐他汀二聚体含量的辛伐他汀的商业规模的方法。