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    Sustained release of Apo A-I mimetic peptides and methods of treatment
    1.
    发明授权
    Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
    持续释放Apo A-I模拟肽和治疗方法

    公开(公告)号：US09173890B2

    公开(公告)日：2015-11-03

    申请号：US11946028

    申请日：2007-11-27

    申请人： Katsuyuki Murase ,  Jinping Wan ,  John Stankus ,  Dariush Davalian ,  Florian Ludwig

    发明人： Katsuyuki Murase ,  Jinping Wan ,  John Stankus ,  Dariush Davalian ,  Florian Ludwig

    IPC分类号： A61K38/00 ,  A61K31/661 ,  A61K9/14 ,  A61K38/10 ,  A61K38/17 ,  A61P3/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/16 ,  A61K9/51

    CPC分类号： A61K31/661 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/127 ,  A61K9/1647 ,  A61K9/5153 ,  A61K38/17

    摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

    摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

    SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT
    10.
    发明申请
    SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
    可持续发布的APO A-I型胶原蛋白和治疗方法

    公开(公告)号：US20090081293A1

    公开(公告)日：2009-03-26

    申请号：US11946028

    申请日：2007-11-27

    申请人： Katsuyuki Murase ,  Jinping Wan ,  John Stankus ,  Dariush Davalian ,  Florian Ludwig

    发明人： Katsuyuki Murase ,  Jinping Wan ,  John Stankus ,  Dariush Davalian ,  Florian Ludwig

    IPC分类号： A61K9/10 ,  A61K31/661 ,  A61K9/14 ,  A61K38/10 ,  A61K38/17 ,  A61P3/00

    CPC分类号： A61K31/661 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/127 ,  A61K9/1647 ,  A61K9/5153 ,  A61K38/17

    摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

    摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。