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公开(公告)号：US20130260667A1
公开(公告)日：2013-10-03
申请号：US13432917
申请日：2012-03-28
CPC分类号： F24F13/082 , F24F13/06 , Y10T29/49826
摘要： A method and system for inhibiting the flow of air through a vent or vent plate within a living space. The present system includes a cover and side walls of a vent cover that are formed in the shape of the vent plate. Attached to the vent cover are magnets that are positioned on the vent cover to align with fasteners of the vent plate. The alignment of the magnets with the fasteners enables the vent cover to be securely attached to the vent plate via and prevent the flow of air from the living space.
摘要翻译： 一种用于抑制空气流过生活空间内的通风口或排气板的方法和系统。 本系统包括形成为排气板形状的通气盖的盖和侧壁。 安装在排气罩上的是磁铁，它们位于通气盖上，以与排气板的紧固件对准。 磁体与紧固件的对准使得通气盖能够通过并通过并且防止来自生活空间的空气流而牢固地附接到排气板。
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公开(公告)号：US12012591B2
公开(公告)日：2024-06-18
申请号：US17316054
申请日：2021-05-10
IPC分类号： C12N13/00 , A61M1/36 , B01D15/38 , B01F31/23 , B01F33/452 , B03C1/01 , B03C1/033 , B03C1/034 , B03C1/28 , G01N33/543
CPC分类号： C12N13/00 , A61M1/3618 , B01D15/3885 , B01F31/23 , B01F33/452 , B03C1/01 , B03C1/0332 , B03C1/034 , B03C1/288 , G01N33/54326 , B03C2201/18 , B03C2201/22 , B03C2201/26
摘要： An apparatus and methods are provided for the magnetic separation of target bioentities. The apparatus includes a fluid chamber and a magnetic element for drawing target bioentities toward a collection surface of the fluid chamber. The apparatus may include a positioning assembly operable to variable change the position and orientation f the fluid chamber relative to the magnetic element.
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公开(公告)号：US20180044900A1
公开(公告)日：2018-02-15
申请号：US15790306
申请日：2017-10-23
申请人： Joseph Francis
发明人： Joseph Francis
摘要： A system and method for unclogging a drain involving at least one internal member and at least one external member. At least one member is ferromagnetic, and at least one member is a magnet. External members may have handles. Internal members are disposed inside a pipe and external members are disposed outside a pipe. When an external member is moved, the magnetic force between the internal and external members causes the internal member to move. Internal members can be disposed such that they cause a clog to move further into the drain system. Internal members can also be disposed such that they are below the clog when it forms, allowing the internal members to move the clog out of the pipe system, into the sink, toilet, or other basin. Safety members can be disposed below the internal members to prevent loss of internal members into pipe system.
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公开(公告)号：US09072736B2
公开(公告)日：2015-07-07
申请号：US13360565
申请日：2012-01-27
申请人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , K. Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , K. Roger Aoki , Joseph Francis , Lance Steward
CPC分类号： C12Y304/24069 , A61K38/00 , A61K38/1709 , A61K38/482 , A61K38/4886 , A61K38/4893 , A61K47/6415 , A61K47/65 , C07K14/665 , C07K2319/055 , C07K2319/06 , C07K2319/50 , C12N9/52 , C12N15/62
摘要： Use of a therapeutic molecule, for the treatment of specific pain conditions, wherein the therapeutic molecule is a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment can cleave a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a Targeting Moiety that can bind to a Binding Site on the nociceptive sensory afferent, which Binding Site can undergo endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the Targeting Moiety; and a translation domain that can translocate the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent.
摘要翻译： 用于治疗特定疼痛病症的治疗分子的用途，其中所述治疗分子是单链多肽融合蛋白，其包含：非细胞毒性蛋白酶或其片段，所述蛋白酶或蛋白酶片段可以切割蛋白质或蛋白酶片段的蛋白质 伤害性感觉传入的胞外融合装置; 可以结合伤害性感觉传入物上的结合位点的靶向物质，其结合位点可以进行内吞作用以掺入伤害性感觉传入体内的内体; 蛋白酶切割位点，其中融合蛋白可被蛋白酶切割，其中蛋白酶切割位点位于非细胞毒性蛋白酶或其片段与靶向部位之间; 以及可以将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入物的胞质溶胶中的翻译结构域。
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公开(公告)号：US08984423B2
公开(公告)日：2015-03-17
申请号：US11147603
申请日：2005-06-07
IPC分类号： G06F3/00 , G06F3/0481 , G06F9/44
CPC分类号： G06F3/0484 , G05B15/02 , G06F3/0481 , G06F9/4411 , G06F17/30864
摘要： A technique is provided for configuring an interface device. Individual device elements are stored on the interface device and each element includes a functionality and a visual representation. A general purpose engine resident on the interface device enumerates properties of the device elements in response to a query in a design-time environment. Design-time environment may be served to a general purpose computer working as a configuration station. The general purpose engine is independent of the device elements enumerated. A user viewable screen is then generated for viewing in the design-time environment, with the potential for altering properties of the enumerated device elements. The viewable screen and design-time environment may be displayed in a general purpose viewer or browser by collecting the visual representations associated with the device elements.
摘要翻译： 提供了一种配置接口设备的技术。 单个设备元件存储在接口设备上，并且每个元件包括功能和视觉表示。 驻留在接口设备上的通用引擎在设计时环境中枚举响应于查询的设备元素的属性。 可以将设计时环境提供给作为配置站工作的通用计算机。 通用引擎独立于枚举的设备元素。 然后，可以在设计时环境中生成用户可查看的屏幕，以改变枚举的设备元素的属性。 可视屏幕和设计时环境可以通过收集与设备元件相关联的视觉表示来显示在通用查看器或浏览器中。
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公开(公告)号：US08918733B2
公开(公告)日：2014-12-23
申请号：US11147590
申请日：2005-06-07
CPC分类号： G06F9/4443 , G06F9/451
摘要： A technique is provided for enhancing the performance of an interface device. A collection of device elements having properties including a visual representation and a functionality are instantiated in a global container. The global container includes the device elements that are required for various screen views. Device elements that are not required in a currently displayed screen view are torn off in the global container so that memory and processing requirements are reduced, while increasing the speed and performance of the interface, particularly in switching between screen views.
摘要翻译： 提供了一种用于增强接口设备的性能的技术。 包含视觉表示和功能的属性的设备元素的集合在全局容器中被实例化。 全局容器包括各种屏幕视图所需的设备元素。 当前显示的屏幕视图中不需要的设备元素在全局容器中被拆除，从而降低了存储器和处理要求，同时增加了界面的速度和性能，特别是在屏幕视图之间切换。
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7.发明授权公开(公告)号：US08898123B2
公开(公告)日：2014-11-25
申请号：US11147607
申请日：2005-06-07
摘要： A technique is provided for configuring an interface device. The interface device includes a plurality of device elements, such as objects configured in accordance with object-oriented programming concepts. A query from a general purpose viewer is received by the interface device, such as originating from a configuration station where the general purpose viewer is operative. The query is interpreted by server-side scripting executed in the interface device to identify the device elements and to display visual representations of the device elements in a design-time environment. The design-time environment and the visual representations are then transmitted to a configuration station. The device elements, their properties and functionalities may be altered by means of the design-time environment and the server-side scripting to create interface screens, alter device elements and their properties and functions, and so forth.
摘要翻译： 提供了一种配置接口设备的技术。 接口设备包括多个设备元件，诸如根据面向对象编程概念配置的对象。 来自通用观察者的查询由接口设备接收，诸如从通用目的查看器可操作的配置站发起。 通过在接口设备中执行的服务器端脚本来解释查询，以识别设备元素，并在设计时环境中显示设备元素的视觉表示。 然后将设计时环境和视觉表示传输到配置站。 可以通过设计时环境和服务器端脚本来改变设备元件，其属性和功能，以创建接口屏幕，改变设备元件及其属性和功能，等等。
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公开(公告)号：US08667824B2
公开(公告)日：2014-03-11
申请号：US12940235
申请日：2010-11-05
CPC分类号： B21D26/12 , B21D26/10 , B21D31/04 , Y10T29/49805
摘要： An electrode assembly for electro-hydraulic forming tool in which the insulation sleeve is assembled over an electrode rod. The insulation sleeve has a deflection surface that is beveled or oriented at an angle relative to the axis of the electrode rod. The electrode assembly may include a replaceable conical receptacle that facilitates placement of an electrode tip an insulation sleeve tip. An electrode tip profile that is shaped to minimize erosion caused by discharge of the electro-hydraulic forming machine.
摘要翻译： 一种用于电液成形工具的电极组件，其中绝缘套管组装在电极棒上。 绝缘套管具有相对于电极棒的轴线成一角度倾斜或定向的偏转表面。 电极组件可以包括可更换的圆锥形容器，其有利于将电极尖端放置在绝缘套筒尖端上。 电极尖端轮廓，其被成形为最小化由电液压成型机的排放引起的侵蚀。
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9.发明授权Modified Clostridial toxins with enhanced targeting capabilities for endogenous Clostridial toxin receptor systems 有权改良的梭菌毒素具有增强的内源性梭菌毒素受体系统的靶向能力公开(公告)号：US08623999B2
公开(公告)日：2014-01-07
申请号：US13406422
申请日：2012-02-27
申请人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
发明人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域和增强的梭菌毒素结合结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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公开(公告)号：US08534095B2
公开(公告)日：2013-09-17
申请号：US13444099
申请日：2012-04-11
IPC分类号： C03C15/00 , C03B32/02 , C03B23/037
CPC分类号： G02B1/08 , C03B23/047 , C03B32/00 , C03C3/11 , C03C4/04 , G02B27/283
摘要： The invention is directed to a glass composition and articles made from the composition that are both polarizing and photorefractive. The glass has, for example, a composition consisting essentially of, in weight percent (“wt. %”) of 70-73 SiO2, 13-17% B2O3, 8-10% Na2O, 2-4% Al2O3, 0.005-0.1% CuO,
摘要翻译： 本发明涉及一种玻璃组合物和由该组合物制成的物镜，它们均为偏振光和光折射。 玻璃具有例如基本上由70-73SiO 2，13-17％B 2 O 3，8-10％Na 2 O，2-4％Al 2 O 3，0.005-0.1重量百分比（“wt％”）组成的组合物 ％CuO，<0.4％Cl，0.1-0.5％Ag，0.1-0.3％Br。 在另一个实施方案中，组合物基本上由70-77％SiO 2，13-18％B 2 O 3，8-10％Na 2 O，2-4％Al 2 O 3，0.005-0.1％CuO，0.4％Cl，0.1-0.5％Ag，0.1 -0.3％Br。 该玻璃可用于制造在单个元件或制品内既能表现光折射效应又具有偏光效果的制品或元件，并且可用于制造各种光学元件，包括布拉格光栅，滤光元件和光束成形元件，以及 用于显示，安全，防御，计量，成像和通信应用的光采集元件。
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