摘要:
A method for diagnosing Alzheimer's disease by detecting the presence of beta-amyloid in cells using a phototransistor device. Cells that potentially contain beta-amyloid are provided and labeled with a multi-protein that selectively binds to beta-amyloid if present and that includes streptavidin, biotin and polyethylene glycol connected in sequence with the streptavidin being bound to a magnetic bead and the polyethylene glycol being bound to the beta-amyloid, to provide labeled cells. A phototransistor device including a channel layer is provided and a difference in photocurrent determined corresponding to incident light measured before and after selectively fixing the labeled cells on a surface of the channel layer by applying an external magnetic field effective to attract the magnetic bead to the phototransistor device through a permanent magnet positioned below the channel. Any difference between the first and second photocurrents indicates the presence of, and optionally amount of, labeled beta-amyloid in the cells.
摘要:
Provided are a method of diagnosing Alzheimer's disease using a giant magnetoresistance sensor and a magnetic bead-polyprotein complex for diagnosing Alzheimer's disease. The method of diagnosing Alzheimer's disease using the giant magnetoresistance sensor may be applied to diagnose Alzheimer's disease more easily and simply using the giant magnetoresistance sensor than using conventional fluorescent materials or genetic analyses, and the magnetic bead-polyprotein complex may be mass-produced as a diagnostic biosensor for Alzheimer's disease, and thus to be useful to monitor and treat Alzheimer's disease.
摘要:
An apparatus for eliminating motion artifacts in a bio signal includes a bio signal acquisition unit configured to acquire a bio signal from a patient; a reconstruction signal generator configured to generate a reconstruction signal of the acquired bio signal based on a result of comparing the acquired bio signal with a bio signal pattern of the patient generated using a bio signal measured from the patient before acquiring the bio signal from the patient; and a motion artifact elimination unit configured to eliminate motion artifacts in the acquired bio signal based on a difference between the reconstruction signal and the acquired bio signal.
摘要:
An apparatus for eliminating motion artifacts in a bio signal includes a bio signal acquisition unit configured to acquire a bio signal from a patient; a reconstruction signal generator configured to generate a reconstruction signal of the acquired bio signal based on a result of comparing the acquired bio signal with a bio signal pattern of the patient generated using a bio signal measured from the patient before acquiring the bio signal from the patient; and a motion artifact elimination unit configured to eliminate motion artifacts in the acquired bio signal based on a difference between the reconstruction signal and the acquired bio signal.
摘要:
Disclosed is a method for the early diagnosis of Alzheimer's disease. In the method, cells in which a biomarker characteristic of Alzheimer's disease, preferably beta-amyloid, is labeled with magnetic beads are selectively located in the channel region of a phototransistor, and a difference in photocurrent between normal cells and the cells comprising the protein biomarker labeled with magnetic beads is sensed to diagnose Alzheimer's disease at an early stage.
摘要:
A peak detecting method is provided. The peak detecting method includes receiving a biological signal that represents an electrical characteristic difference between electrodes attached to a patient, receiving an activity signal that represents an amount of activity of the patient from an activity sensor detecting activity of the patient, detecting at least one of a plurality of peaks in the input biological signal on the basis of the activity signal, and outputting information regarding the detected peak.