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    Method for early diagnosis of alzheimer'S disease using phototransistor
    1.
    发明授权
    Method for early diagnosis of alzheimer'S disease using phototransistor 有权
    使用光电晶体管早期诊断阿尔茨海默氏病的方法

    公开(公告)号：US09023607B2

    公开(公告)日：2015-05-05

    申请号：US13093152

    申请日：2011-04-25

    申请人： Kwan-Su Kim ,  Cheol-Joo Chae ,  Jae-Min Kang ,  Jeong-Dae Suh ,  Myung-Ae Chung ,  Ki-Bong Song

    发明人： Kwan-Su Kim ,  Cheol-Joo Chae ,  Jae-Min Kang ,  Jeong-Dae Suh ,  Myung-Ae Chung ,  Ki-Bong Song

    IPC分类号： C12Q1/00 ,  B82Y15/00 ,  G01N33/68

    CPC分类号： B82Y15/00 ,  G01N33/6896 ,  G01N2800/2821

    摘要： A method for diagnosing Alzheimer's disease by detecting the presence of beta-amyloid in cells using a phototransistor device. Cells that potentially contain beta-amyloid are provided and labeled with a multi-protein that selectively binds to beta-amyloid if present and that includes streptavidin, biotin and polyethylene glycol connected in sequence with the streptavidin being bound to a magnetic bead and the polyethylene glycol being bound to the beta-amyloid, to provide labeled cells. A phototransistor device including a channel layer is provided and a difference in photocurrent determined corresponding to incident light measured before and after selectively fixing the labeled cells on a surface of the channel layer by applying an external magnetic field effective to attract the magnetic bead to the phototransistor device through a permanent magnet positioned below the channel. Any difference between the first and second photocurrents indicates the presence of, and optionally amount of, labeled beta-amyloid in the cells.

    摘要翻译： 一种通过使用光电晶体管装置检测细胞中β-淀粉样蛋白的存在来诊断阿尔茨海默病的方法。 提供可能含有β-淀粉样蛋白的细胞并用选择性结合β-淀粉样蛋白（如果存在）的多蛋白标记，并且包括与链霉抗生物素蛋白结合到磁珠上的序列连接的链霉抗生物素蛋白，生物素和聚乙二醇，并且聚乙二醇 结合β-淀粉样蛋白，以提供标记细胞。 提供了包括沟道层的光电晶体管装置，并且通过施加有效吸引磁珠到光电晶体管的外部磁场选择性地将标记的单元选择性地固定在通道层的表面之前和之后测量的入射光确定的光电流差异 设备通过位于通道下方的永磁体。 第一和第二光电流之间的任何差异表明在细胞中存在和任选量的标记的β-淀粉样蛋白。

    METHOD AND APPARATUS FOR ELIMINATING MOTION ARTIFACTS OF BIO SIGNAL USING PERSONALIZED BIO SIGNAL PATTERN
    3.
    发明申请
    METHOD AND APPARATUS FOR ELIMINATING MOTION ARTIFACTS OF BIO SIGNAL USING PERSONALIZED BIO SIGNAL PATTERN 有权
    消除使用个性化生物信号模式的生物信号运动制品的方法和装置

    公开(公告)号：US20130211271A1

    公开(公告)日：2013-08-15

    申请号：US13648054

    申请日：2012-10-09

    申请人： Jae-min Kang ,  Kun-kook Park ,  Kun-soo Shin

    发明人： Jae-min Kang ,  Kun-kook Park ,  Kun-soo Shin

    IPC分类号： A61B5/0402

    CPC分类号： A61B5/04525 ,  A61B5/721

    摘要： An apparatus for eliminating motion artifacts in a bio signal includes a bio signal acquisition unit configured to acquire a bio signal from a patient; a reconstruction signal generator configured to generate a reconstruction signal of the acquired bio signal based on a result of comparing the acquired bio signal with a bio signal pattern of the patient generated using a bio signal measured from the patient before acquiring the bio signal from the patient; and a motion artifact elimination unit configured to eliminate motion artifacts in the acquired bio signal based on a difference between the reconstruction signal and the acquired bio signal.

    摘要翻译： 一种用于消除生物信号中的运动伪影的装置包括被配置为从患者获取生物信号的生物信号获取单元; 重建信号发生器，其被配置为基于获得的生物信号与从患者获得生物信号之前使用从患者测量的生物信号产生的患者的生物信号模式的结果来生成所获取的生物信号的重建信号， ; 以及运动伪像消除单元，其被配置为基于所述重建信号和所获取的生物信号之间的差异来消除所获取的生物信号中的运动伪像。

    Method and apparatus for eliminating motion artifacts of bio signal using personalized bio signal pattern
    4.
    发明授权
    Method and apparatus for eliminating motion artifacts of bio signal using personalized bio signal pattern 有权
    使用个性化生物信号模式消除生物信号运动伪影的方法和装置

    公开(公告)号：US08798726B2

    公开(公告)日：2014-08-05

    申请号：US13648054

    申请日：2012-10-09

    申请人： Jae-min Kang ,  Kun-kook Park ,  Kun-soo Shin

    发明人： Jae-min Kang ,  Kun-kook Park ,  Kun-soo Shin

    IPC分类号： A61B5/04

    CPC分类号： A61B5/04525 ,  A61B5/721

    摘要： An apparatus for eliminating motion artifacts in a bio signal includes a bio signal acquisition unit configured to acquire a bio signal from a patient; a reconstruction signal generator configured to generate a reconstruction signal of the acquired bio signal based on a result of comparing the acquired bio signal with a bio signal pattern of the patient generated using a bio signal measured from the patient before acquiring the bio signal from the patient; and a motion artifact elimination unit configured to eliminate motion artifacts in the acquired bio signal based on a difference between the reconstruction signal and the acquired bio signal.

    摘要翻译： 一种用于消除生物信号中的运动伪影的装置包括被配置为从患者获取生物信号的生物信号获取单元; 重建信号发生器，其被配置为基于获得的生物信号与从患者获得生物信号之前使用从患者测量的生物信号产生的患者的生物信号模式的结果来生成所获取的生物信号的重建信号， ; 以及运动伪像消除单元，其被配置为基于所述重建信号和所获取的生物信号之间的差异来消除所获取的生物信号中的运动伪像。

    METHOD AND APPARATUS FOR DETECTING PEAK FROM BIOLOGICAL SIGNAL
    6.
    发明申请
    METHOD AND APPARATUS FOR DETECTING PEAK FROM BIOLOGICAL SIGNAL 审中-公开
    用于检测生物信号峰值的方法和装置

    公开(公告)号：US20120259182A1

    公开(公告)日：2012-10-11

    申请号：US13437104

    申请日：2012-04-02

    申请人： Youn-ho KIM ,  Jae-min KANG ,  Kun-soo SHIN ,  Tak-hyung LEE

    发明人： Youn-ho KIM ,  Jae-min KANG ,  Kun-soo SHIN ,  Tak-hyung LEE

    IPC分类号： A61B5/05 ,  A61B5/11

    CPC分类号： A61B5/0456 ,  A61B5/1118

    摘要： A peak detecting method is provided. The peak detecting method includes receiving a biological signal that represents an electrical characteristic difference between electrodes attached to a patient, receiving an activity signal that represents an amount of activity of the patient from an activity sensor detecting activity of the patient, detecting at least one of a plurality of peaks in the input biological signal on the basis of the activity signal, and outputting information regarding the detected peak.

    摘要翻译： 提供峰值检测方法。 所述峰值检测方法包括接收表示附着于患者的电极之间的电特性差异的生物信号，从所述患者的活动传感器检测活动中接收表示所述患者的活动量的活动信号， 基于活动信号输入生物信号中的多个峰值，并输出关于检测到的峰值的信息。