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1.
公开(公告)号:US20060189661A1
公开(公告)日:2006-08-24
申请号:US11398556
申请日:2006-04-06
申请人: Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
发明人: Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
IPC分类号: C07D413/04 , A61K31/4439
CPC分类号: C07D213/75 , C07D213/55 , C07D213/78 , C07D213/79 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14
摘要: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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2.Use of N-alkylamino-heterocylic compounds for the treatment of migraine 失效
标题翻译: N-烷基氨基 - 杂环化合物用于治疗偏头痛的用途公开(公告)号:US06635639B2
公开(公告)日:2003-10-21
申请号:US10073130
申请日:2002-02-13
申请人: Jalaj Arora , Louise Edwards , Methvin Issac , Anne O'Brien , Abdelmalik Slassi , Ashok Tehim , Tao Xin
发明人: Jalaj Arora , Louise Edwards , Methvin Issac , Anne O'Brien , Abdelmalik Slassi , Ashok Tehim , Tao Xin
IPC分类号: A61K315377
CPC分类号: A61K31/415
摘要: Described are compounds having formula I or II: wherein: X is N, and Ak represents a C1-3 alkylene chain; and a salt, solvate or prodrug thereof.
摘要翻译: 描述的是具有式I或II的化合物:其中:X为N,Ak为C 1-3亚烷基链;及其盐,溶剂合物或前药。
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公开(公告)号:US07935703B2
公开(公告)日:2011-05-03
申请号:US12160959
申请日:2007-01-05
申请人: Abdelmalik Slassi , Methvin Isaac , Jalaj Arora , Dean Brown
发明人: Abdelmalik Slassi , Methvin Isaac , Jalaj Arora , Dean Brown
IPC分类号: A61K31/497 , A61K31/4965 , A61K31/445 , A01N43/40 , C07D211/60 , C07D403/00 , C07D241/04 , C07D295/00 , C07D401/00
CPC分类号: C07D295/108 , C07D211/70 , C07D213/30 , C07D213/61 , C07D213/74 , C07D213/85 , C07D233/64 , C07D239/26 , C07D241/12 , C07D277/24 , C07D295/155 , C07D333/16 , C07D401/12 , C07D409/12
摘要: Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: wherein Ar1, Ar2, A, X, Y, m, n and R1, R2, R3, R4 and R5 are as described in the specification, processes for their preparation, pharmaceutical formulations comprising them and their use in therapy, particularly in the therapy of neurological and psychiatric disorders associated with glutamate dysfunction.
摘要翻译: 式I化合物或其药学上可接受的盐或溶剂合物:其中Ar1,Ar2,A,X,Y,m,n和R1,R2,R3,R4和R5如说明书中所述,其制备方法, 包括它们及其在治疗中的用途,特别是用于治疗与谷氨酸功能障碍相关的神经和精神障碍。
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4.
公开(公告)号:US20080015234A1
公开(公告)日:2008-01-17
申请号:US11840952
申请日:2007-08-18
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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5.New compounds for the treatment of neurological, psychiatric or pain disorders 失效
标题翻译: 用于治疗神经,精神或疼痛疾病的新化合物公开(公告)号:US20070129408A1
公开(公告)日:2007-06-07
申请号:US11523717
申请日:2006-09-20
申请人: Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
发明人: Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
IPC分类号: A61K31/4439 , C07D413/14
CPC分类号: C07D413/14
摘要: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译: 本发明涉及新化合物,它们在治疗中的用途和包含所述新化合物的药物组合物。
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6.Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效
标题翻译: 额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号:US20050272779A1
公开(公告)日:2005-12-08
申请号:US11053752
申请日:2005-02-09
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/4245 , A61K31/4439 , C07D413/14
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译: 本发明涉及新的式I化合物,含有该化合物的药物制剂,以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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公开(公告)号:US20090023711A1
公开(公告)日:2009-01-22
申请号:US12160959
申请日:2007-01-05
申请人: Abdelmalik Slassi , Methvin Isaac , Jalaj Arora , Dean Brown
发明人: Abdelmalik Slassi , Methvin Isaac , Jalaj Arora , Dean Brown
IPC分类号: A61K31/551 , C07D241/04 , A61K31/495 , A61K31/496 , C07D243/08 , C07D401/14 , C07D211/06 , A61K31/451
CPC分类号: C07D295/108 , C07D211/70 , C07D213/30 , C07D213/61 , C07D213/74 , C07D213/85 , C07D233/64 , C07D239/26 , C07D241/12 , C07D277/24 , C07D295/155 , C07D333/16 , C07D401/12 , C07D409/12
摘要: Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: wherein Ar1, Ar2, A, X, Y, m, n and R1, R2, R3, R4 and R5 are as described in the specification, processes for their preparation, pharmaceutical formulations comprising them and their use in therapy, particularly in the therapy of neurological and psychiatric disorders associated with glutamate dysfunction.
摘要翻译: 式I化合物或其药学上可接受的盐或溶剂合物:其中Ar1,Ar2,A,X,Y,m,n和R1,R2,R3,R4和R5如说明书中所述,其制备方法, 包括它们及其在治疗中的用途,特别是用于治疗与谷氨酸功能障碍相关的神经和精神障碍。
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8.
公开(公告)号:US20080015204A1
公开(公告)日:2008-01-17
申请号:US11840955
申请日:2007-08-18
申请人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人: Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号: A61K31/519 , A61K31/4196 , A61K31/4245 , A61P19/02 , A61P25/08 , A61P25/28 , A61P27/02 , A61P35/00 , C07D271/06 , C07D487/04 , C07D413/14 , A61P9/00 , A61P29/00 , A61P25/30 , A61P25/18 , A61P19/06 , A61K31/443 , A61K31/4439
CPC分类号: C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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9.NEW COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS 审中-公开
标题翻译: 用于治疗神经,心理或疼痛疾病的新化合物公开(公告)号:US20070270469A1
公开(公告)日:2007-11-22
申请号:US11829867
申请日:2007-07-27
申请人: Alexander MINIDIS , David WENSBO , Methvin ISAAC , Abdelmalik SLASSI , Jalaj ARORA , Tao XIN , Louise Edwards , Caroline ERIKSSON , Veronica PROFIR , Per-Olov BERGSTROM
发明人: Alexander MINIDIS , David WENSBO , Methvin ISAAC , Abdelmalik SLASSI , Jalaj ARORA , Tao XIN , Louise Edwards , Caroline ERIKSSON , Veronica PROFIR , Per-Olov BERGSTROM
IPC分类号: A61K31/4427 , A61P25/00 , A61P29/00 , A61P43/00 , C07D213/02
CPC分类号: C07D413/14
摘要: The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译: 本发明涉及新化合物,它们在治疗中的用途和包含所述新化合物的药物组合物。
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公开(公告)号:US07112595B2
公开(公告)日:2006-09-26
申请号:US10699563
申请日:2003-11-03
申请人: Bradford Van Wagenen , Thomas M. Stormann , Scott T Moe , Susan M Sheehan , Donald McLeod , Daryl L Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
发明人: Bradford Van Wagenen , Thomas M. Stormann , Scott T Moe , Susan M Sheehan , Donald McLeod , Daryl L Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
IPC分类号: A61K31/44 , C07D401/02
CPC分类号: C07D213/75 , C07D213/55 , C07D213/78 , C07D213/79 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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