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公开(公告)号：US08337754B2
公开(公告)日：2012-12-25
申请号：US12644839
申请日：2009-12-22
Applicant: Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
Inventor： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
IPC: G01N21/00
CPC classification number: G01N1/31 , B01L3/0217 , B01L2200/147 , B01L2200/16 , B01L2300/1822 , B01L2400/0487 , G01N1/30 , G01N27/44721 , G01N33/54366 , G01N35/00029 , G01N35/10 , G01N2035/00425 , Y10T436/2575
Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.
Abstract translation: 本文公开了用于开发免疫染色的生物样品的系统和方法。 本文公开的系统是自动化的并且被配置为控制开发过程的一个或多个步骤。 可以使用自动注射器分注添加试剂。 试剂温度，试剂搅拌和洗涤程序是可编程的，可以单独控制，同时进行单独的免疫染色程序。
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公开(公告)号：US20120201727A1
公开(公告)日：2012-08-09
申请号：US13450303
申请日：2012-04-18
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
IPC: B01L3/00
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
Abstract translation: 这里公开了一种模块化试管架。 机架包含多个可以耦合在一起以形成试管架的子机架。 子机架可以设计成适合各种科学仪器，包括固定转子离心机。 组装的试管架可以是允许使用标准阵列移液器的格式和尺寸。 因此，提供允许使用标准阵列移液器和高g离心的系统。
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公开(公告)号：US08178055B2
公开(公告)日：2012-05-15
申请号：US12475381
申请日：2009-05-29
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
IPC: G01N21/75
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
Abstract translation: 这里公开了一种模块化试管架。 机架包含多个可以耦合在一起以形成试管架的子机架。 子机架可以设计成适合各种科学仪器，包括固定转子离心机。 组装的试管架可以是允许使用标准阵列移液器的格式和尺寸。 因此，提供允许使用标准阵列移液器和高g离心的系统。
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4.发明授权Multiwell assay apparatus and method for determining biological activity of compounds 有权多孔测定装置和化合物生物活性测定方法公开(公告)号：US08852881B2
公开(公告)日：2014-10-07
申请号：US11605814
申请日：2006-11-29
Applicant: Paul A. Negulescu , Alec T. Harootunian , Philip E. Salzmann , Javier H. Flores , James E. Sinclair , Minh Vuong , Ashvani K. Singh , Fred F. VanGoor
Inventor： Paul A. Negulescu , Alec T. Harootunian , Philip E. Salzmann , Javier H. Flores , James E. Sinclair , Minh Vuong , Ashvani K. Singh , Fred F. VanGoor
CPC classification number: B01L3/5085 , B01L3/50255 , B01L2300/0645 , B01L2300/0829
Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.”
Abstract translation: 用于表征细胞的生物学特性的装置可以包括多个双隔室测定室，其中每个室的隔室被离子可以流过的细胞层分开。 在存在或不存在实验化合物的情况下，细胞层的生物学性质可以通过测量该层的电梯度来确定。 这种类型的单室双腔室可以称为“尿素室”。
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公开(公告)号：US20110151482A1
公开(公告)日：2011-06-23
申请号：US12644839
申请日：2009-12-22
Applicant: Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
Inventor： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
CPC classification number: G01N1/31 , B01L3/0217 , B01L2200/147 , B01L2200/16 , B01L2300/1822 , B01L2400/0487 , G01N1/30 , G01N27/44721 , G01N33/54366 , G01N35/00029 , G01N35/10 , G01N2035/00425 , Y10T436/2575
Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.
Abstract translation: 本文公开了用于开发免疫染色的生物样品的系统和方法。 本文公开的系统是自动化的并且被配置为控制开发过程的一个或多个步骤。 可以使用自动注射器分注添加试剂。 试剂温度，试剂搅拌和洗涤程序是可编程的，可以单独控制，同时进行单独的免疫染色程序。
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Patent Agency Ranking
公开(公告)号：US07919047B2
公开(公告)日：2011-04-05
申请号：US11446821
申请日：2006-06-05
Applicant: James E. Sinclair , Michael P. Emery , Minh Vuong
Inventor： James E. Sinclair , Michael P. Emery , Minh Vuong
IPC: B01L3/02
CPC classification number: B01L3/0217 , B01L9/52 , B01L2200/0689
Abstract: An air displacement pipetter comprises a guidance sleeve positioned within a hole in a cylinder block and a piston within a portion of the guidance sleeve a piston penetrating the cylinder block, a spring energized seal disposed within the cylinder block, a seal capture plate contacting the spring energized seal, a carrier plate, a pipette tip attached to the carrier plate, and a manifold plate between said carrier plate and said cylinder block.
Abstract translation: 排气移液器包括定位在气缸体的孔内的引导套筒和引导套筒的一部分内的活塞，穿过气缸体的活塞，设置在气缸体内的弹簧加压密封件，与弹簧接触的密封件捕获板 通电密封件，承载板，附接到承载板的移液管末端，以及在所述承载板和所述气缸体之间的歧管板。
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7.发明授权公开(公告)号：US07429359B2
公开(公告)日：2008-09-30
申请号：US10388960
申请日：2003-03-14
Applicant: Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
Inventor： Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
IPC: B01L3/02
CPC classification number: B01L3/0268 , B01L9/523 , B01L2300/0829 , B01L2400/0439 , G01N35/028 , G01N2035/042 , G01N2035/0425 , G01N2035/1041
Abstract: An apparatus for high-throughput screening and generation of chemical libraries. The apparatus comprises computer controlled mechanical displacement devices and storage queues capable of managing a large number of source well plates and target well plates. In one aspect of the invention, precession alignment mechanisms are provided for efficient transfer of liquid from source well plates to target well plates. The apparatus may be configured such that any source fluid in any of the source well plates may be transferred to any target location within any of the target well plates in any sequence defined by the user. The computer controller may track the location of all the source well plates and target well plates and allow user defined association of any source well with any target well in any order defined by the user, thus providing an effective platform for chemical and biochemical synthesis and screening.
Abstract translation: 用于高通量筛选和化学文库生成的设备。 该装置包括能够管理大量源井板和目标井板的计算机控制的机械位移装置和存储队列。 在本发明的一个方面，提供了进动对准机构，用于将液体从源阱板有效转移到目标井板。 该装置可以被配置成使得任何源阱板中的任何源流体可以按照用户定义的任何顺序传送到任何目标阱板内的任何目标位置。 计算机控制器可以跟踪所有源井板和目标井板的位置，并允许用户根据用户定义的任何顺序将任何源井与任何目标井定义关联，从而为化学和生物化学合成和筛选提供有效的平台 。
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公开(公告)号：US08398941B2
公开(公告)日：2013-03-19
申请号：US13450303
申请日：2012-04-18
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
IPC: B01L3/00
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
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公开(公告)号：US07553671B2
公开(公告)日：2009-06-30
申请号：US10853901
申请日：2004-05-25
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
IPC: B01L9/00
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
Abstract translation: 这里公开了一种模块化试管架。 机架包含多个可以耦合在一起以形成试管架的子机架。 子机架可以设计成适合各种科学仪器，包括固定式转子离心机。 组装的试管架可以是允许使用标准阵列移液器的格式和尺寸。 因此，提供允许使用标准阵列移液器和高g离心的系统。
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10.发明授权Acoustically mediated liquid transfer method for generating chemical libraries 有权用于生成化学文库的声学介质液体转移方法公开(公告)号：US06863362B2
公开(公告)日：2005-03-08
申请号：US10388880
申请日：2003-03-14
Applicant: Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
Inventor： Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
IPC: B05B1/08 , B41J29/393 , G01N35/00
CPC classification number: B01L3/0268 , B01L9/523 , B01L2300/0829 , B01L2400/0439 , G01N35/028 , G01N2035/042 , G01N2035/0425 , G01N2035/1041
Abstract: An apparatus for high-throughput screening and/or generation of chemical libraries. In one aspect of the invention, a database is provided to track various parameters related to the source fluids in the source containment structure. Tracking changes of the source fluids in each source well may allow efficient utilization of source fluid and may also facilitate the high-throughput fluid transfer process. In one variation, data related to fluid level in each source well is maintained such that proper positioning of acoustic wave focus may be achieved. In another aspect of the invention, a database associated with one or more source fluid containment structure is provided and updated during the fluid transfer process. A second database providing a mapping profile with information regarding which fluid is to be transferred to what target is also provided. A third database may be generated to track fluid information in the target well plates.
Abstract translation: 用于高通量筛选和/或生成化学文库的设备。 在本发明的一个方面，提供数据库以跟踪与源容纳结构中的源流体相关的各种参数。 跟踪每个源阱中的源流体的变化可以允许源流体的有效利用并且还可以促进高通量流体转移过程。 在一个变型中，保持与每个源阱中的液位相关的数据，使得可以实现声波聚焦的适当定位。 在本发明的另一方面，在流体转移过程期间提供并更新与一个或多个源流体容纳结构相关联的数据库。 第二数据库提供映射配置文件，其中还提供了关于哪些流体要传送到什么目标的信息。 可以生成第三数据库以跟踪目标井板中的流体信息。
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