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公开(公告)号：US08452359B2
公开(公告)日：2013-05-28
申请号：US11973790
申请日：2007-10-10
申请人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
发明人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译： 用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。
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公开(公告)号：US5452390A
公开(公告)日：1995-09-19
申请号：US231569
申请日：1994-04-22
CPC分类号： G02B6/4248 , G02B6/421 , G02B6/4292 , G02B6/3863 , G02B6/3875 , G02B6/3897
摘要： A detachable fiber optic connector provides connection from an optical source or sink through a hermetic connection to a removable attached optical fiber. Ferrules and a split ring are used for alignment. A variety of alternative embodiments are illustrated for providing coupling force between the ferrules and retaining forces to prevent movement of the connection during movement of the fiber relative to the optical source or sink. These detachable fiber optic connectors provide great benefit when combined with hermetic packaging.
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公开(公告)号：US5450515A
公开(公告)日：1995-09-12
申请号：US231568
申请日：1994-04-22
CPC分类号： G02B6/4248 , G02B6/421 , G02B6/4292 , G02B6/3863 , G02B6/3875 , G02B6/3897
摘要： A detachable fiber optic connector provides connection from an optical source or sink through a hermetic connection to a removable attached optical fiber. Ferrules and a split ring are used for alignment. A variety of alternative embodiments are illustrated for providing coupling force between the ferrules and retaining forces to prevent movement of the connection during movement of the fiber relative to the optical source or sink. These detachable fiber optic connectors provide great benefit when combined with hermetic packaging.
摘要翻译： 可拆卸光纤连接器提供从光源或接收器通过气密连接到可拆卸附接光纤的连接。 套圈和开环用于对齐。 示出了各种备选实施例，用于提供套圈之间的联接力和保持力，以防止在光纤相对于光源或吸收槽移动期间连接的移动。 这些可拆卸的光纤连接器在与气密包装相结合时提供了极大的好处。
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4.发明授权公开(公告)号：US07944556B2
公开(公告)日：2011-05-17
申请号：US12722043
申请日：2010-03-11
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14556 , G01N21/6456 , G01N21/65 , G01N2021/6423
摘要： A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.
摘要翻译： 对光学像差校正光谱图像。 组织暴露于高强度，窄带光。 窄带光被组织中的至少一种分析物散射。 拉曼信号从散射光中被光学收集。 拉曼信号被引导到波长分离装置。 作为强度和波长的函数检测拉曼信号以产生光谱图像。 使用软件算法对光学像差校正光谱图像以空间重新分配强度。 该软件可以适于使用参考图像进行动态校正。 也可以收集荧光信号。
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5.发明申请公开(公告)号：US20100226549A1
公开(公告)日：2010-09-09
申请号：US12722043
申请日：2010-03-11
IPC分类号： G06K9/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14556 , G01N21/6456 , G01N21/65 , G01N2021/6423
摘要： A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.
摘要翻译： 对光学像差校正光谱图像。 组织暴露于高强度，窄带光。 窄带光被组织中的至少一种分析物散射。 拉曼信号从散射光中被光学收集。 拉曼信号被引导到波长分离装置。 作为强度和波长的函数检测拉曼信号以产生光谱图像。 使用软件算法对光学像差校正光谱图像以空间重新分配强度。 该软件可以适于使用参考图像进行动态校正。 也可以收集荧光信号。
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公开(公告)号：US20100113897A1
公开(公告)日：2010-05-06
申请号：US12530157
申请日：2008-03-14
申请人： Allen J. Brenneman , James E. Smous
发明人： Allen J. Brenneman , James E. Smous
IPC分类号： A61B5/1459 , A61B5/145 , A61B5/1473 , B23P11/00
CPC分类号： A61B5/6833 , A61B5/14532 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B2560/0412 , Y10T29/49826
摘要： A continuous analyte monitoring assembly is adapted to assist in determining an analyte level of a fluid. The monitoring assembly includes a housing, electronics, an implantable sensor and a cannula. The housing has a bottom in which the bottom forms a recess. The electronics are located within the housing and assist in determining an analyte level of a fluid sample. The sensor moves from a retracted position to an inserted position using the recess. The cannula assists in placing the implantable sensor.
摘要翻译： 连续分析物监测组件适于帮助确定流体的分析物水平。 监测组件包括壳体，电子器件，可植入传感器和套管。 壳体具有底部，底部形成凹部。 电子设备位于壳体内并有助于确定流体样品的分析物水平。 传感器使用凹槽从缩回位置移动到插入位置。 套管有助于放置可植入传感器。
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公开(公告)号：US07299079B2
公开(公告)日：2007-11-20
申请号：US10361895
申请日：2003-02-11
申请人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
发明人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue, the system comprising an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译： 一种用于确定身体组织中的至少一种体液中的分析物的浓度的系统，所述系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。
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8.发明授权Silicon carrier for testing and alignment of optoelectronic devices and method of assembling same 失效用于光电器件测试和对准的硅载体及其组装方法
公开(公告)号：US5432878A
公开(公告)日：1995-07-11
申请号：US205673
申请日：1994-03-03
申请人： James E. Smous
发明人： James E. Smous
CPC分类号： G02B6/4236 , G02B6/423 , G02B6/3652 , G02B6/3692 , G02B6/4238 , G02B6/4239
摘要： An optoelectronic subassembly is illustrated which ensures the alignment of multiple optoelectronic devices without special assembly process. The optoelectronic devices are mounted upon specially designed sub-carriers which may be used to test the devices prior to completing the subassembly. The subassembly improves yields of complex optoelectronic systems and lowers resultant production costs.
摘要翻译： 示出了一种光电子组件，其确保了多个光电子器件的对准，而无需特殊的组装过程。 光电子器件安装在专门设计的子载体上，可以在完成子组件之前用于测试器件。 该组件提高了复杂光电子系统的产量，降低了生产成本。
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9.发明授权Apparatus for nondestructively determining coating thickness on a metal object and associated method 失效用于非破坏性地确定金属物体上的涂层厚度的装置和相关方法
公开(公告)号：US5281819A
公开(公告)日：1994-01-25
申请号：US711521
申请日：1991-06-06
CPC分类号： G01B11/0658 , G01N2021/646
摘要： Apparatus and an associated method for nondestructively determining the thickness of a coating on a metal surface, such as the interior of a can. An object securing device holds the object being inspected. The inspection device includes a probe. Positioning apparatus is employed to permit insertion of the probe into inspecting relationship which in the case of a can would involve partial insertion of the probe into the can. A first section is inspected and sequentially through relative rotational and/or translational movement of the object being inspected additional portions of the object such as can ends may be inspected. A light beam is caused to impinge upon the section of the object being inspected and returned fluorescent light received by a detector positioned within the probe cooperates with processing means to determine the coating thickness. The system permits accurate determinations of coating thickness even when the metal surface has irregularities. The system may be employed on metal sheet including moving metal sheet. The probe may include mirrors and fiberoptic components. A suitable lens for focusing the returned light and a filter for excluding extraneous returned light from the detector preferably are employed. A container holder is also provided.
摘要翻译： 用于非破坏性地确定金属表面（例如罐的内部）上的涂层的厚度的装置和相关方法。 物体固定装置保持被检查物体。 检查装置包括探针。 使用定位装置来允许将探针插入到检查关系中，在关于罐的情况下将涉及将探针部分插入罐中的检查关系。 通过被检查对象的相对旋转和/或平移运动来检查和顺序地检查第一部分，可以检查对象的诸如罐端部的附加部分。 导致光束撞击被检查物体的部分，并且由位于探针内的检测器接收的返回荧光与处理装置协调以确定涂层厚度。 该系统即使当金属表面具有不规则性时，也能准确地确定涂层厚度。 该系统可以用于包括移动金属板的金属板上。 探头可以包括镜子和光纤组件。 优选地，使用用于聚焦返回光的合适透镜和用于从检测器排除外来返回光的滤光器。 还提供容器支架。
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公开(公告)号：US08160666B2
公开(公告)日：2012-04-17
申请号：US11974477
申请日：2007-10-12
申请人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
发明人： Mihailo V. Rebec , James E. Smous , Steven D. Brown , Hu-Wei Tan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译： 用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在与体液中的分析物相关的算法上进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。
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