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    Reagents for asymmetric allylation, aldol, and tandem aldol and allyation reactions
    1.
    发明授权
    Reagents for asymmetric allylation, aldol, and tandem aldol and allyation reactions 有权
    不对称烯丙基化，醛醇醛和串联醛醇缩合反应的试剂

    公开(公告)号：US07534905B2

    公开(公告)日：2009-05-19

    申请号：US10504831

    申请日：2003-03-03

    申请人： James L. Leighton ,  Xiaolun Wang ,  James Kinnaird

    发明人： James L. Leighton ,  Xiaolun Wang ,  James Kinnaird

    IPC分类号： C07F7/10 ,  C07F7/08 ,  C07F7/18

    CPC分类号： C07C403/08 ,  C07B2200/07 ,  C07C29/38 ,  C07C41/30 ,  C07C43/1787 ,  C07C43/23 ,  C07C241/04 ,  C07C2601/14 ,  C07F7/045 ,  C07F7/12 ,  C07F7/122 ,  C07F7/1804 ,  C07F7/1876 ,  C07F7/188 ,  C07C243/28 ,  C07C33/48 ,  C07C33/03 ,  C07C33/14 ,  C07C33/26 ,  C07C33/30

    摘要： A new class of reagents and method of use of the reagents in the reaction of the reagents with electrophilic compounds. The invention in one embodiment is directed to a method for the formation of an alcohol of the formula (I). The method includes reacting a reagent of the formula (II) with an aldehyde of the formula R10CHO to form the alcohol. X3 is one of O and C(R4)(R5). Each of X1 and X2 is independently O or N—R. Each of Ca and Cb is independently an achiral center, an (S) chiral center or an (R) chiral center. Ra and Rb are (i) each independently C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl, or (ii) taken together to form a C3—C4 alkylene chain which together with Ca and Cb forms a 5-membered or 6-membered aliphatic ring. Rc and Rd are each independently hydrogen, C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. R is C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. Each of R1, R2, R3, R4, R5 is independently hydrogen, C1—C10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 dialkylamino, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, or halogen. R6 is halogen, hydrogen, C1-10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, OSO2CF3 or SR. R10 may be C1-10 alkyl, C6-10 aryl, or C3-9 heteroaryl.

    摘要翻译： 在试剂与亲电子化合物的反应中使用新一类试剂和试剂的使用方法。 在一个实施方案中，本发明涉及形成式（I）的醇的方法。 该方法包括使式（II）的试剂与式R 10 CHO的醛反应以形成醇。 X3是O和C（R4）（R5）之一。 X1和X2各自独立地为O或N-R。 Ca和Cb各自独立地是非手性中心，（S）手性中心或（R）手性中心。 R a和R b分别为（i）各自独立地为C 1-10烷基，C 6-10芳基或C 3-9杂芳基，或（ii）一起形成C 3 -C 4亚烷基链，其与Ca和Cb一起形成5元或 6元脂肪环。 R c和R d各自独立地为氢，C 1-10烷基，C 6-10芳基或C 3-9杂芳基。 R是C 1-10烷基，C 6-10芳基或C 3-9杂芳基。 R 1，R 2，R 3，R 4，R 5各自独立地为氢，C 1 -C 10烷基，C 6-10芳基，C 3-9杂芳基，C 1-10烷氧基，C 6-10芳氧基，C 1-10二烷基氨基，C 1-10烷基 - C6-10芳基氨基，C1-10二芳基氨基或卤素。 R6是卤素，氢，C1-10烷基，C6-10芳基，C3-9杂芳基，C1-10烷氧基，C6-10芳氧基，C1-10烷基-C6-10芳基氨基，C1-10二芳基氨基，OSO2CF3或SR。 R 10可以是C 1-10烷基，C 6-10芳基或C 3-9杂芳基。

    Production of 3-alkoxyalkanals by hydroformylation of enol ether substrates
    4.
    发明授权
    Production of 3-alkoxyalkanals by hydroformylation of enol ether substrates 失效
    通过烯醇醚底物的加氢甲酰化生产3-烷氧基烷烃

    公开(公告)号：US6057458A

    公开(公告)日：2000-05-02

    申请号：US969178

    申请日：1997-11-12

    申请人： James L. Leighton ,  Deidre N. O'Neil

    发明人： James L. Leighton ,  Deidre N. O'Neil

    IPC分类号： C07D319/06

    CPC分类号： C07D319/06

    摘要： The present invention provides a process for producing an optically active aldehyde which comprises hydroformylating a terminal olefin substrate represented by the formula:Q.sub.1 Q.sub.2 C.dbd.CH.sub.2wherein Q.sub.1 is an atom or group other than carbon or hydrogen and Q.sub.2 is an atom or group other than hydrogen, in the presence of CO, H.sub.2 and a catalyst, which catalyst comprises a transition metal based compound and a ligand.

    摘要翻译： 本发明提供了一种制备光学活性醛的方法，该方法包括加氢甲酰化下式所示的末端烯烃底物：Q1Q2C = CH2，其中Q1是除碳或氢以外的原子或基团，Q2是除氢以外的原子或基团， CO，H2和催化剂的存在，该催化剂包含过渡金属基化合物和配体。