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1.发明申请Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof 有权含有苯并醌的Ansamycins的类似物及其使用方法公开(公告)号：US20120058982A1
公开(公告)日：2012-03-08
申请号：US13191761
申请日：2011-07-27
Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC: A61K31/395 , A61P35/00
CPC classification number: A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
Abstract translation: 本发明提供了含苯醌的安莎霉素类似物及其用于治疗和调节与过度增生相关的疾病如癌症的用途。 本发明提供了含有苯醌的安莎霉素的类似物，其中苯醌被还原成氢醌并通过与合适的酸反应而被捕获，优选是增加所得17-氢醌醌霉素类似物的溶解度和空气稳定性的那些。
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公开(公告)号：US07566706B2
公开(公告)日：2009-07-28
申请号：US11105203
申请日：2005-04-13
Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC: A61P35/00
CPC classification number: A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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公开(公告)号：US20090062528A1
公开(公告)日：2009-03-05
申请号：US12229277
申请日：2008-08-20
Applicant: Brian C. Austad , Louis Grenier , Edward B. Holson , John J. Lee , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Brian C. Austad , Louis Grenier , Edward B. Holson , John J. Lee , Roger H. Pak , James R. Porter , James L. Wright
IPC: C07D225/06
CPC classification number: A61K9/146 , A61K31/33 , C07D225/04
Abstract: Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”).
Abstract translation: 特别地，本文提供了固体形式的格尔德霉素类似物，包含格尔德霉素类似物和结晶抑制剂的药物组合物，制备和使用这些组合物的方法。 另外，提供了用于治疗癌症，肿瘤疾病状态和/或过度增殖性疾病的方法，以及抑制热休克蛋白90（“Hsp90”）的方法。
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公开(公告)号：US20080255080A1
公开(公告)日：2008-10-16
申请号：US12101473
申请日：2008-04-11
Applicant: James L. Wright , James R. Porter
Inventor： James L. Wright , James R. Porter
IPC: A61K31/395 , A61P35/00 , A61P35/02
CPC classification number: A61K31/7016 , A61K31/395 , A61K2300/00
Abstract: Pharmaceutical compositions of hydroquinone geldanamycin analogs, and uses of such compositions, are provided.
Abstract translation: 提供氢醌格尔德霉素类似物的药物组合物，以及这些组合物的用途。
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公开(公告)号：US4098149A
公开(公告)日：1978-07-04
申请号：US740835
申请日：1976-11-11
Applicant: James L. Wright
Inventor： James L. Wright
CPC classification number: B23D63/14 , B23D63/123
Abstract: A dual side saw tooth grinding machine with power-driven grinding wheel assemblies mounted on pivoted supporting arms organized so that edge portions of grinding wheels in the assemblies are moved in sweeps across opposite sides of a tip in a saw tooth when grinding the same.
Abstract translation: 一种双侧锯齿磨床，其具有安装在枢转支撑臂上的动力磨轮组件，其组合成使得当研磨该组件时，组件中的研磨轮的边缘部分扫过锯齿的尖端的相对侧。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08703755B2
公开(公告)日：2014-04-22
申请号：US13589581
申请日：2012-08-20
Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC: A61P35/00
CPC classification number: A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
Abstract translation: 本发明提供了含苯醌的安莎霉素类似物及其用于治疗和调节与过度增生相关的疾病如癌症的用途。 本发明提供了含有苯醌的安莎霉素的类似物，其中苯醌被还原成氢醌并通过与合适的酸反应而被捕获，优选是增加所得17-氢醌醌霉素类似物的溶解度和空气稳定性的那些。
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公开(公告)号：US20090253653A1
公开(公告)日：2009-10-08
申请号：US12199578
申请日：2008-08-27
Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC: C07D225/04 , C07D491/04 , C07D498/04 , A61K31/395 , A61K31/445 , A61K31/5383 , A61P35/04
CPC classification number: A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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公开(公告)号：US07579337B2
公开(公告)日：2009-08-25
申请号：US12199415
申请日：2008-08-27
Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC: C07D225/06 , A61K31/395 , A61P35/00
CPC classification number: A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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公开(公告)号：US20090209549A1
公开(公告)日：2009-08-20
申请号：US12369545
申请日：2009-02-11
Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
IPC: A61K31/506 , A61K31/33 , A61K31/337
CPC classification number: A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
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公开(公告)号：US20090069281A1
公开(公告)日：2009-03-12
申请号：US12229326
申请日：2008-08-20
Applicant: Brian C. Austad , Louis Grenier , Edward B. Holson , John J. Lee , Roger H. Pak , James R. Porter , James L. Wright
Inventor： Brian C. Austad , Louis Grenier , Edward B. Holson , John J. Lee , Roger H. Pak , James R. Porter , James L. Wright
IPC: A61K31/395 , A61P35/00 , A61P35/02 , C07D225/06
CPC classification number: A61K9/146 , A61K31/33 , C07D225/04
Abstract: Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”).
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