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    Compositions and methods for bacillus anthracis vaccination
    3.
    发明申请
    Compositions and methods for bacillus anthracis vaccination 审中-公开
    炭疽芽孢杆菌接种的组合物和方法

    公开(公告)号：US20150266933A1

    公开(公告)日：2015-09-24

    申请号：US11786861

    申请日：2007-04-13

    Applicant: James R. Baker, JR. ,  Anna Bielinska ,  Andrzej Myc

    Inventor： James R. Baker, JR. ,  Anna Bielinska ,  Andrzej Myc

    IPC: C07K14/32

    CPC classification number: C07K14/32 ,  A61K39/07 ,  A61K2039/543 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575

    Abstract: The present invention relates to methods and compositions for stimulating an immune response. Specifically, the present invention provides methods of inducing an immune response to bacteria of the genus Bacillus (e.g., Bacillus anthracis) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising Bacillus anthracis or an immunogenic portion thereof). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination) and research applications.

    Abstract translation: 本发明涉及用于刺激免疫应答的方法和组合物。 具体地，本发明提供了在受试者（例如，人类受试者）中诱导针对芽孢杆菌属（例如，炭疽杆菌）的细菌的免疫应答的方法和可用于这些方法的组合物（例如，包含炭疽芽孢杆菌或 其免疫原性部分）。 本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物（例如，疫苗接种）和研究应用）。

    Dendrimer conjugates
    4.
    发明授权
    Dendrimer conjugates 有权
    树枝状结合物

    公开(公告)号：US08889635B2

    公开(公告)日：2014-11-18

    申请号：US12570977

    申请日：2009-09-30

    Applicant: James R. Baker, Jr. ,  Xue-min Cheng ,  Abraham F. L. Van Der Spek ,  Baohua Mark Huang ,  Thommey P. Thomas

    Inventor： James R. Baker, Jr. ,  Xue-min Cheng ,  Abraham F. L. Van Der Spek ,  Baohua Mark Huang ,  Thommey P. Thomas

    IPC: A61K31/5513 ,  A61K31/485 ,  A61K31/5377 ,  C07D489/02 ,  A61K47/48

    CPC classification number: A61K47/483 ,  A61K31/485 ,  A61K47/595

    Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    Abstract translation: 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

    Pro-drug complexes and related methods of use
    5.
    发明授权
    Pro-drug complexes and related methods of use 有权
    前药复合物及相关使用方法

    公开(公告)号：US08853151B2

    公开(公告)日：2014-10-07

    申请号：US13378178

    申请日：2010-06-30

    Applicant: James R. Baker, Jr. ,  Baohua M. Huang ,  Thommey P. Thomas

    Inventor： James R. Baker, Jr. ,  Baohua M. Huang ,  Thommey P. Thomas

    IPC: A61K31/4745 ,  A61K38/12 ,  C07D491/147 ,  C07K7/64 ,  A61K31/437 ,  A61K47/48

    CPC classification number: A61K31/437 ,  A61K47/64

    Abstract: The present invention provides methods, compositions and applications for efficient, site-specific drug delivery using pro-drug complexes comprising one or more functional groups (e.g., imaging agents, targeting agents, and trigger agents) conjugated with a therapeutic agent (e.g., a chemotherapeutic agent), methods of synthesizing the same, as well as systems and methods utilizing the therapeutic and diagnostic compositions (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.))). Trigger agents include an indolequinone; attachment groups include a triazole ring; and therapeutic agents include camptothecin.

    Abstract translation: 本发明提供了使用包含与治疗剂缀合的一种或多种官能团（例如成像剂，靶向剂和触发剂）的前药复合物进行有效的位点特异性药物递送的方法，组合物和应用（例如， 化学治疗剂），其合成方法以及利用治疗和诊断组合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如， ，疾病（例如癌症）诊断和/或治疗等）））。 触发剂包括吲哚醌; 连接基团包括三唑环; 治疗剂包括喜树碱。

    Analytical system with photonic crystal sensor
    6.
    发明授权
    Analytical system with photonic crystal sensor 有权
    光子晶体传感器分析系统

    公开(公告)号：US08497992B2

    公开(公告)日：2013-07-30

    申请号：US12616457

    申请日：2009-11-11

    Applicant: Jingyong Ye ,  Jason E. Gestwicki ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Tommaso F. Bersano-Begey

    Inventor： Jingyong Ye ,  Jason E. Gestwicki ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Tommaso F. Bersano-Begey

    IPC: G01N21/55

    CPC classification number: G02B1/005 ,  B82Y20/00 ,  G01N21/553

    Abstract: A system for determining whether interaction occurs between a trial substance and a target substance. The system includes a photonic crystal sensor having a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface able to receive the target substance and the trial substance. The system further includes a light source that inputs a light signal to the photonic crystal structure and the defect member. The light signal is internally reflected, and a resultant output signal is outputted. The output signal relates to whether the trial substance interacts with the target substance at the operative surface. Furthermore, the system includes an identity detector that identifies the trial substance that interacts with the target substance.

    Abstract translation: 用于确定试验物质与目标物质之间是否发生相互作用的系统。 该系统包括具有光子晶体结构的光子晶体传感器和邻近光子晶体结构设置的缺陷部件。 缺陷构件限定能够接收目标物质和试验物质的手术表面。 该系统还包括将光信号输入到光子晶体结构和缺陷部件的光源。 光信号被内部反射，并输出合成的输出信号。 输出信号涉及试验物质在操作表面与目标物质的相互作用。 此外，该系统包括识别与目标物质相互作用的试验物质的身份检测器。

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