公开(公告)号：US08657601B2

公开(公告)日：2014-02-25

申请号：US10482736

申请日：2002-06-26

Applicant: Jan Hall

Inventor： Jan Hall

IPC: A61L27/54

CPC classification number: A61L27/54 ,  A61C8/0012 ,  A61C8/0013 ,  A61C2008/0046 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2002/30797 ,  A61F2002/30866 ,  A61F2002/30924 ,  A61F2002/30925 ,  A61F2002/30929 ,  A61F2002/3097 ,  A61F2310/00023 ,  A61F2310/00976 ,  A61L27/50 ,  A61L2300/252 ,  A61L2300/606

Abstract: An implant (10) has one or more surfaces (10a, 10b) with a basic or starting surface structure (1a) derived from mechanical working. A topographic modification of the surface structures is arranged on said surface structure or surface structures. The topographic modification can be formed, for example, by means of shot-peening, etching, plasma spraying, chemical action, etc. The topographically modified surface structures support bone-growth-stimulating agent. In a method for producing the implant, three subsidiary methods are used for carrying out the mechanical working, the topographical modification, and the application of the bone-growth-stimulating agent. An important niche in the demand which exists in the field of implants is thus covered in an advantageous manner.

Abstract translation: 植入物（10）具有一个或多个来自机械加工的具有基础或起始表面结构（1a）的表面（10a，10b）。 在所述表面结构或表面结构上布置表面结构的形貌变化。 地形修改可以例如通过喷丸，蚀刻，等离子体喷涂，化学作用等形成。表面改性的表面结构支持骨生长刺激剂。 在用于生产植入物的方法中，使用三种辅助方法进行机械加工，形貌修饰和骨生长刺激剂的应用。 因此，在植入物领域中存在的需求中的重要利基被以有利的方式覆盖。

公开(公告)号：US08439919B2

公开(公告)日：2013-05-14

申请号：US12634466

申请日：2009-12-09

Applicant: Jan Hall

Inventor： Jan Hall

IPC: A61B17/56 ,  A61B17/58 ,  A61F2/30

CPC classification number: A61C8/0022 ,  A61C2008/0046 ,  A61F2002/30011 ,  A61F2002/30321 ,  A61F2002/30859 ,  A61F2002/30871 ,  A61F2002/30874 ,  A61F2002/30927 ,  A61F2250/0023 ,  A61F2250/0025

Abstract: An implant (4) is provided with attachment and hole-insert parts (2, 3) with surfaces which have different degrees of finishing and/or degrees of roughness and/or porosities (2f, 2g). Arranged on the surfaces there is at least one dozen (A-B) in which the degree of finishing and/or the degree of roughness and/or the porosity is continuously changed. The changes in porosity in said zones can mirror continuous or discontinuous changes in the bone in question, for example the jaw bone or tooth bone. The continuously changed zones can be obtained with the aid of electrolyte (15) and, connected to the latter, an anode and cathode arrangement (13, 14). When establishing the porosity, it is possible to mask different portions of the respective implant and to control the temperature of the implant.

公开(公告)号：US08167618B2

公开(公告)日：2012-05-01

申请号：US12210899

申请日：2008-09-15

Applicant: Jan Hall

Inventor： Jan Hall

IPC: A61C8/00

CPC classification number: A61L27/54 ,  A61C8/0009 ,  A61C8/0012 ,  A61L2300/414

Abstract: The stability of an implant (5) which is fitted in a jaw bone hole created by tooth root extraction is increased using osteoinductive material. Bone formation in the space between the implant and the bone wall is also stimulated. In an initial stage, the implant is anchored or fitted in the hole. With its outer parts (5a) the implant extends into a part (4a) of the hole which has a cross-sectional area exceeding the crossectional area of the outer parts (5a) of the implant. The soft tissue of the jaw bone, with possible periosteum, covers the implant and the space to form a closed space (4a). The bioactive material consists of growth-stimulating substances (GSS) arranged on the implant. In a stage of incorporation, GSS passes outward into body fluid which has penetrated into the closed space and interacts with cells present in the fluid so that new bone is formed around the outer pats (5a) of the implant. The invention also relates to a use and to an implant. The invention also simplifies the handling of implants.

Abstract translation: 使用骨诱导材料增加了通过牙根提取产生的装配在颚骨孔中的植入物（5）的稳定性。 在植入物和骨壁之间的空间中的骨形成也被刺激。 在初始阶段，植入物被锚固或装配在孔中。 通过其外部部分（5a），植入物延伸到孔的部分（4a）中，该部分的横截面积超过植入物的外部部分（5a）的横截面面积。 具有可能的骨膜的颚骨的软组织覆盖植入物和空间以形成封闭空间（4a）。 生物活性物质由植入物上的生长刺激物质（GSS）组成。 在并入阶段，GSS向外通入已经渗透到封闭空间中并与存在于流体中的细胞相互作用的体液，使得在植入物的外部片（5a）周围形成新骨。 本发明还涉及一种用途和植入物。 本发明还简化了植入物的处理。

公开(公告)号：US07713307B1

公开(公告)日：2010-05-11

申请号：US09980006

申请日：2000-05-23

Applicant: Jan Hall ,  Jukka Lausmaa

Inventor： Jan Hall ,  Jukka Lausmaa

IPC: A61F2/28

CPC classification number: A61C8/0012 ,  A61C8/0015 ,  A61L27/306 ,  A61L27/56

Abstract: A layer (2∝″) is arranged on an implant (1″) for bone or tissue structure (5). The layer constitutes a boundary or a barrier between the actual or unoxidized body of the implant (1″) and the structure for the purpose of increasing retention and has in this context, a substantial thickness (T′). The layer (2′″) is designed with a channel network (6) which gives the layer a substantial porosity. The channel network (6) is designed with mouths (3′,4′) which face towards the structure (5) and whose respective cross-sectional diameters (D), at the surface (2a′) of the layer (2′″) facing towards the structure (5), are substantially less than the respective extents (e.g., H) of the channels in and down into the layer (2′″) as seen from the said surface (2a′).

Abstract translation: 在用于骨或组织结构（5）的植入物（1“）上布置有层（2α”）。 该层构成植入物（1“）的实际或未氧化体与用于增加保留性的结构之间的边界或屏障，并且在本文中具有相当大的厚度（T'​​）。 层（2“”）被设计成具有通道网络（6），其使层具有显着的孔隙率。 通道网络（6）设计有朝向结构（5）的口（3'，4'），并且在层（2“）的表面（2a'）处具有各自的横截面直径（D） ）基本上小于从所述表面（2a'）看到的在层（2“”）内和向下的通道的相应范围（例如，H）。

公开(公告)号：US20090047632A1

公开(公告)日：2009-02-19

申请号：US12211532

申请日：2008-09-16

Applicant: Jan Hall

Inventor： Jan Hall

IPC: A61C8/00

CPC classification number: A61L27/227 ,  A61C8/0009 ,  A61C8/0012

Abstract: An implant bears growth-stimulating substance(s), here called GSS, which can be released when the implant is arranged in a jaw bone hole. The release takes place in interaction with secreted, cell-containing body fluid so as to form new bone alongside the implant. The implant is arranged with an outer surface which can comprise the outer parts of a thread or can consist of bearing surfaces parallel to the inner wall of the jaw bone hole. First portions of the outer surface have first diameters or radii, and second portions have second diameters or radii smaller than the first diameters or radii. The implant bears against or cooperates with the hole wall via the first portions and, by means of the second portions and together with the hole wall, forms one or more closed spaces into which body fluid can penetrate and GSS can be released. The implant can alternatively be designed with a shape or shapes substantially corresponding to the tooth root configuration(s). The new bond formation is made effective in this way, and great stability can be obtained for the implant in its position in the jaw bone.

Abstract translation: 植入物具有生长刺激物质，这里称为GSS，当植入物布置在颚骨孔中时，其可被释放。 释放发生在与分泌的含细胞体液的相互作用中，以在植入物旁边形成新骨。 植入物布置有外表面，该外表面可以包括螺纹的外部部分，或者可以由平行于颚骨孔的内壁的轴承表面组成。 外表面的第一部分具有第一直径或半径，第二部分具有小于第一直径或半径的第二直径或半径。 植入物经由第一部分抵靠或与孔壁配合，并且借助于第二部分并与孔壁一起形成一个或多个闭合空间，体液可以渗透到其中并且GSS可被释放。 可替代地，植入物可被设计成基本上对应于牙根构造的形状或形状。 以这种方式使新的结合形成有效，并且可以获得植入物在其在颚骨中的位置的极大的稳定性。

公开(公告)号：US20090024220A1

公开(公告)日：2009-01-22

申请号：US12236903

申请日：2008-09-24

Applicant: Jan Hall

Inventor： Jan Hall

IPC: A61F2/02

CPC classification number: A61C8/0015 ,  A61C8/0012 ,  A61C8/0013 ,  A61C8/0022 ,  A61C8/0092 ,  A61L27/227

Abstract: An arrangement and an implant are provided for increasing the stress resistance of the implant arranged in an upper jaw bone (1). The implant has access via parts (9, 4′) to the sinus cavity (5). At said parts, the implant is arranged with a convex or rounded front surface which, upon access, lifts the sinus mucous membrane, without piercing the latter, and thus forms a closed space (7) between the parts and the underside of the mucous membrane. The implant is provided, at least at said parts, with growth-stimulating substance or substances (15) which interact with cell-containing body fluid (8) which penetrates or has penetrated into the space, so that new bone (11) is formed around said parts of the implant.

Abstract translation: 提供了一种布置和植入物，用于增加布置在上颚骨（1）中的植入物的抗应力。 植入物通过部件（9,4'）到达窦腔（5）。 在所述部分，植入物被布置成具有凸形或圆形的前表面，其在进入时提升窦粘膜而不刺穿窦粘膜，从而在粘膜的部分和下侧之间形成封闭空间（7） 。 所述植入物至少在所述部分处具有生长刺激性物质或物质（15），所述生长刺激物质或物质（15）与穿透或已渗透到所述空间中的含细胞体液（8）相互作用，从而形成新的骨骼（11） 围绕植入物的部分。

公开(公告)号：US06419708B1

公开(公告)日：2002-07-16

申请号：US09403387

申请日：2000-01-20

Applicant: Jan Hall ,  Anatol Krozer ,  Peter Thomsen

Inventor： Jan Hall ,  Anatol Krozer ,  Peter Thomsen

IPC: A61F228

CPC classification number: C23C14/5806 ,  A61C8/0012 ,  A61C8/0013 ,  A61F2310/00796 ,  A61L27/32 ,  C23C14/0057 ,  C23C14/08

Abstract: The invention relates to an implant element for permanent anchorage in bone tissue in which at least the surface intended to face the tissue in the implantation region is made of a biocompatible material such as titanium and having a clinically well documented surface. The element is provided with a thin, uniform and adherent calcium-phosphate coating with a well controlled dissolution rate. The coating follows the topography of the underlying well documented surface in order to combine properties for rapid bone growth during the healing phase and properties for a guaranteed long-term stability during clinical loading conditions.

Abstract translation: 本发明涉及用于在骨组织中永久锚定的植入元件，其中至少在植入区域中旨在面向组织的表面由诸如钛的生物相容性材料制成并且具有临床上良好记录的表面。 该元件设置有具有良好控制的溶解速率的薄，均匀和粘附的磷酸钙涂层。 涂层遵循下面良好记录的表面的形貌，以便在愈合阶段期间结合用于快速骨生长的性质和在临床加载条件下保证长期稳定性的性质。

公开(公告)号：US06312472B1

公开(公告)日：2001-11-06

申请号：US09530420

申请日：2000-07-19

Applicant: Jan Hall ,  Leif Hermansson

Inventor： Jan Hall ,  Leif Hermansson

IPC: A61F236

CPC classification number: A61L27/40 ,  A61L27/04 ,  A61L27/10 ,  A61L27/306 ,  A61L27/32

Abstract: The object of the invention is to make available implant elements or other medical products made of biological material with optimum mechanical and biological properties for a wide group of materials by introduction of a specially designed surface layer onto a strong core, where the surface layer is densified by means of hot isostatic pressing and dimensioned according to the basic fracture mechanics equation so that the thickness of the surface layer is less than c in the equation KIC=Y&sgr; c½, where Klc is the fracture toughness, Y a position and shape factor, c the critical defect size, and &sgr; the permitted stress for the actual material and the chosen design stress.

Abstract translation: 本发明的目的是通过将特殊设计的表面层引入到强核上，其中表面层被致密化，从而为宽范围的材料制成具有最佳机械和生物学特性的生物材料制成的植入元件或其它医疗产品 通过热等静压和根据基本断裂力学方程定尺寸，使得表面层的厚度在KIC = Ysigma c 1/2中小于c，其中Klc是断裂韧性，Y是位置和形状因子，c 临界缺陷尺寸和西格玛实际材料的允许应力和选定的设计应力。

公开(公告)号：US08113834B2

公开(公告)日：2012-02-14

申请号：US12126542

申请日：2008-05-23

Applicant: Jan Hall

Inventor： Jan Hall

IPC: A61C8/00

CPC classification number: A61L27/227 ,  A61C8/0006 ,  A61F2/2803 ,  A61F2/2846 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61L2430/02

Abstract: Two or more implants (8, 9, 10) are arranged in succession in the jaw bone (1) and bear or comprise growth-stimulating substances (25), here called GSS, which, as a function of secretion of body fluid at the implants, are intended to be released and form new bone (11-15) around the implants. The implants are designed to work with a release process for GSS, permitting a leveling-out effect along the extent of the jaw bone in the horizontal and/or vertical direction and/or a level-raising effect in the vertical direction. In this way it is possible to achieve optimum positions for the implants without the risk of reduced stability and/or compromised esthetics.

Abstract translation: 两个或更多个植入物（8,9,10）被连续排列在颚骨（1）中，并且承载或包含生长刺激物质（25），这里称为GSS，其作为在体外液体分泌的功能 植入物，旨在被释放并在植入物周围形成新的骨骼（11-15）。 植入物设计用于GSS的释放过程，允许沿着颚骨在水平和/或垂直方向上的程度的平移效应和/或垂直方向上的升高效果。 以这种方式，可以实现植入物的最佳位置，而不会降低稳定性和/或损害美学的风险。

公开(公告)号：US20100112519A1

公开(公告)日：2010-05-06

申请号：US12684591

申请日：2010-01-08

Applicant: Jan Hall ,  Jukka Lausmaa

Inventor： Jan Hall ,  Jukka Lausmaa

IPC: A61C13/08

CPC classification number: A61F2/30767 ,  A61C8/0006 ,  A61C8/0012 ,  A61C8/0015 ,  A61F2/2803 ,  A61F2/3094 ,  A61F2002/30011 ,  A61F2002/30036 ,  A61F2002/3085 ,  A61F2002/30927 ,  A61F2250/0023 ,  A61F2250/0035 ,  A61F2310/00023 ,  A61F2310/00616 ,  A61F2310/00976 ,  A61L27/06 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/602

Abstract: An implant comprises titanium and has one or more surfaces which can be applied in or on a bone growth area. One or more of the surfaces are arranged with a depot for bone-growth-initiating or bone-growth-stimulating substance, in which the depot is formed by a pore arrangement in a relatively thick oxide layer on the titanium. The substance is acted on, for a considerable period of time, by one or more release functions for the substance which permit a controlled or optimized release of substance to the surrounding tissue or bone growth area.

Abstract translation: 植入物包括钛并且具有一个或多个可以施加在骨生长区域中或骨生长区域上的表面。 一个或多个表面布置有用于骨生长起始或骨生长刺激物质的贮库，其中通过在钛上相对厚的氧化物层中的孔排列形成贮库。 该物质在相当长的一段时间内通过物质的一种或多种释放功能起作用，所述功能允许将物质控制或优化地释放到周围组织或骨生长区域。