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公开(公告)号：US08846677B2
公开(公告)日：2014-09-30
申请号：US13472090
申请日：2012-05-15
IPC分类号： A61K31/501 , C07D401/00 , C07D409/00
CPC分类号： C07D213/74 , C07D213/84 , C07D213/87 , C07D237/20 , C07D403/04 , C07D403/12 , C07D417/10
摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.
摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。
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公开(公告)号：US08501739B2
公开(公告)日：2013-08-06
申请号：US11917823
申请日：2006-06-30
IPC分类号： A61K31/50 , C07D401/00
CPC分类号： C07D213/74 , C07D213/84 , C07D213/87 , C07D237/20 , C07D403/04 , C07D403/12 , C07D417/10
摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.
摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。
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公开(公告)号：US20120232078A1
公开(公告)日：2012-09-13
申请号：US13472090
申请日：2012-05-15
IPC分类号： A61K31/506 , A61P3/04 , A61P25/24 , A61K31/5377
CPC分类号： C07D213/74 , C07D213/84 , C07D213/87 , C07D237/20 , C07D403/04 , C07D403/12 , C07D417/10
摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.
摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。
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公开(公告)号：US07332508B2
公开(公告)日：2008-02-19
申请号：US10735963
申请日：2003-12-15
IPC分类号： A61K31/454 , C07D43/02
CPC分类号： C07D401/04 , C07D413/04 , C07D413/06 , C07D413/14
摘要： A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the compounds possess histamine H3 receptor antagonistic activity and are thus useful in the treatment of disorders in which a histamine H3 receptor blockade is beneficial.
摘要翻译： 一类新的取代的高哌啶，哌啶和吡咯烷衍生物，其制备方法，包含它们的药物组合物及其用于治疗与组胺H3受体有关的病症的用途。 更具体地，化合物具有组胺H3受体拮抗活性，因此可用于治疗组胺H3受体阻断有益的病症。
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公开(公告)号：US20090312309A1
公开(公告)日：2009-12-17
申请号：US11917823
申请日：2006-06-30
IPC分类号： A61K31/5513 , A61K31/5377 , A61K31/501 , A61K31/497 , C07D413/14 , C07D403/04
CPC分类号： C07D213/74 , C07D213/84 , C07D213/87 , C07D237/20 , C07D403/04 , C07D403/12 , C07D417/10
摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.
摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。
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公开(公告)号：US07799924B2
公开(公告)日：2010-09-21
申请号：US11962455
申请日：2007-12-21
IPC分类号： C07D401/00 , A61K31/445
CPC分类号： C07D401/04 , C07D413/04 , C07D413/06 , C07D413/14
摘要： A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the compounds possess histamine H3 receptor antagonistic activity and are thus useful in the treatment of disorders in which a histamine H3 receptor blockade is beneficial.
摘要翻译： 一类新的取代的高哌啶，哌啶和吡咯烷衍生物，其制备方法，包含它们的药物组合物及其用于治疗与组胺H3受体有关的病症的用途。 更具体地，化合物具有组胺H3受体拮抗活性，因此可用于治疗组胺H3受体阻断有益的病症。
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公开(公告)号：US20080113968A1
公开(公告)日：2008-05-15
申请号：US11784967
申请日：2007-04-10
IPC分类号： A61K31/496 , C07D295/10 , C07D401/02 , C07D401/14 , C07D403/10 , A61K31/551 , A61P3/10 , A61P3/04 , C07D243/08 , C07D405/02 , C07D401/04 , A61K31/495
CPC分类号： C07D213/74 , C07D213/54 , C07D213/56 , C07D231/12 , C07D243/08 , C07D263/58 , C07D277/74 , C07D295/185 , C07D295/192 , C07D295/205 , C07D307/81 , C07D309/14 , C07D317/30 , C07D317/60 , C07D317/62 , C07D319/18 , C07D333/60 , C07D405/12 , C07D409/12 , C07D413/12
摘要： A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
摘要翻译： 一类新的取代的哌嗪和二氮杂环庚烷，包含它们的药物组合物及其用于治疗与组胺H3受体相关的疾病和病症的用途。 更具体地说，这些化合物可用于治疗与组胺H3受体相互作用有益的疾病和病症。
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