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公开(公告)号:US06702705B1
公开(公告)日:2004-03-09
申请号:US08392407
申请日:1995-02-22
申请人: Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
发明人: Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
IPC分类号: C12N900
CPC分类号: C07D207/404 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07C2601/04 , C07C2602/42 , C07D205/085 , C07F9/2408 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/4006 , C07F9/4075 , C07F9/5537 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K14/55 , C07K16/00 , C07K16/1063 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , C12Q1/25 , G01N33/5008 , G01N33/531 , G01N33/577 , G01N2333/16 , G01N2333/96472 , G01N2500/00
摘要: Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
摘要翻译: 公开了催化抗体。 催化抗体对前药化合物是特异性的。 催化抗体增强了活性药物部分与前药残留物的切割,从而激活了药物。
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公开(公告)号:US06258360B1
公开(公告)日:2001-07-10
申请号:US08325554
申请日:1994-10-18
申请人: Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
发明人: Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
IPC分类号: A61K3944
CPC分类号: C07H15/252 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H19/04 , C07K14/55 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , G01N33/5008 , G01N2500/00
摘要: Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.
摘要翻译: 提供由与结合肿瘤细胞群的部分缀合的催化抗体活化并与其缀合的前药。
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