公开(公告)号：USD400093S

公开(公告)日：1998-10-27

申请号：US73813

申请日：1997-07-18

申请人： Anette Israelsson ,  Agneta Pettersson ,  Jan Utas

设计人： Anette Israelsson ,  Agneta Pettersson ,  Jan Utas

公开(公告)号：US08747882B2

公开(公告)日：2014-06-10

申请号：US11407206

申请日：2006-04-20

申请人： Jan Utas ,  Andrea Schmid ,  Agneta Nordholm ,  Martin Nyman

发明人： Jan Utas ,  Andrea Schmid ,  Agneta Nordholm ,  Martin Nyman

IPC分类号： A61L29/14

CPC分类号： A61L29/16 ,  A61L29/14 ,  A61L2300/404 ,  A61L2300/606

摘要： A use in a medical device of at least one salt of organic acid(s), and preferably a benzoate or a sorbate, as an antimicrobial agent is disclosed, and in particular for the manufacturing of an antimicrobial coating for a medical device, e.g., hydrophyllic urinary catheters, for the prevention of bacterial infection. The pH of the hydrophilic coating may be controlled to be in the range 4.0-8.0, preferably in the range 5.0-6.0, and preferably to be below 7.0. The pH of the hydrophilic coating could be controlled by means of a pH buffer, and preferably a citrate or phosphate buffer. A salt of organic acid in combination with a pH buffer has proven surprisingly efficient for inhibition of bacterial growth, and for prevention of bacterial infections.

摘要翻译： 公开了用于医​​疗装置中的至少一种有机酸盐，优选苯甲酸盐或山梨酸盐作为抗微生物剂的用途，特别是用于制造用于医疗器械的抗微生物涂层，例如， 亲水性导尿管，用于预防细菌感染。 亲水涂层的pH可以控制在4.0-8.0的范围内，优选在5.0-6.0的范围内，优选低于7.0。 亲水涂层的pH可以通过pH缓冲液，优选柠檬酸盐或磷酸盐缓冲液来控制。 有机酸与pH缓冲液的组合已被证明对抑制细菌生长和预防细菌感染是非常有效的。

公开(公告)号：US20120318685A1

公开(公告)日：2012-12-20

申请号：US13598492

申请日：2012-08-29

申请人： Jan UTAS ,  Kristina Kull

发明人： Jan UTAS ,  Kristina Kull

IPC分类号： A61M27/00 ,  B65B55/22 ,  B01F17/00 ,  A61B19/02

CPC分类号： A61L29/085 ,  A61L29/14 ,  A61M25/0017 ,  A61M25/002

摘要： A catheter assembly includes a hydrophilic catheter; a wetting fluid for wetting of the catheter; and a receptacle enclosing at least the insertable part of the catheter and the wetting fluid. The wetting fluid is a solution incorporating at least one osmolality-increasing compound, and the total concentration of the osmolality-increasing compound(s) preferably exceeds 600 mOsm/dm3. The wetting fluid could either be arranged in contact with the hydrophilic surface layer of the catheter in the receptacle, for preservation of the hydrophilic surface layer in a wetted state during accommodation in said receptacle and provision of a ready-to-use catheter assembly, or be arranged to keep the wetting fluid separated from the hydrophilic surface layer of the catheter during storage, but to be brought into contact with said hydrophilic surface layer upon activation before an intended use of the catheter.

摘要翻译： 导管组件包括亲水导管; 用于润湿导管的润湿液体; 以及至少包围导管的可插入部分和润湿液体的容器。 润湿流体是引入至少一种重量摩尔渗透压浓度增加化合物的溶液，并且重量克分子渗透浓度增加化合物的总浓度优选超过600mOsm / dm 3。 润湿流体可以布置成与容器中的导管的亲水表面层接触，以便在容纳在所述容器中的湿润状态下保持亲水性表面层，并提供即用型导管组件，或 被布置为在储存期间保持润湿流体与导管的亲水性表面层分离，但在导管的预期使用之前被激活时与所述亲水性表面层接触。

公开(公告)号：US08267919B2

公开(公告)日：2012-09-18

申请号：US10584073

申请日：2004-12-22

申请人： Jan Utas ,  Kristina Kull

发明人： Jan Utas ,  Kristina Kull

IPC分类号： A61M1/00

CPC分类号： A61L29/085 ,  A61L29/14 ,  A61M25/0017 ,  A61M25/002

摘要： A catheter assembly is disclosed comprising: a hydrophilic catheter; a wetting fluid for wetting of the catheter; and a receptacle enclosing at least the insertable part of the catheter and the wetting fluid. Further, the wetting fluid is a solution incorporating at least one osmolality-increasing compound, and the total concentration of the osmolality-increasing compound(s) is very high, preferably exceeding 600 mOsm/dm3. The wetting fluid could either be arranged in contact with the hydrophilic surface layer of the catheter in the receptacle, for preservation of the hydrophilic surface layer in a wetted state during accommodation in said receptacle and provision of a ready-to-use catheter assembly, or be arranged to keep the wetting fluid separated from the hydrophilic surface layer of the catheter during storage, but to be brought into contact with said hydrophilic surface layer upon activation before an intended use of the catheter. A similar method and wetting fluid is disclosed as well. The provision of the osmolality-increasing compound in the wetting fluid provides several advantages per se, such as a improved properties of the hydrophilic coating, a more predictable and controllable wetting process, a more expedient and cost efficient production, etc. Further, the use of this very high concentration of osmolality-increasing compound in the wetting fluid has proven remarkably efficient.

摘要翻译： 公开了一种导管组件，包括：亲水导管; 用于润湿导管的润湿液体; 以及至少包围导管的可插入部分和润湿液体的容器。 此外，润湿流体是引入至少一种重量克分子渗透浓度增加化合物的溶液，并且渗透压浓度增加的化合物的总浓度非常高，优选超过600mOsm / dm 3。 润湿流体可以布置成与容器中的导管的亲水表面层接触，以便在容纳在所述容器中的湿润状态下保持亲水性表面层，并提供即用型导管组件，或 被布置为在储存期间保持润湿流体与导管的亲水性表面层分离，但在导管的预期使用之前被激活时与所述亲水性表面层接触。 还公开了类似的方法和润湿流体。 在润湿流体中提供的重量克分子渗透浓度增加的化合物本身提供了几个优点，例如亲水涂层的改进的性质，更可预测和可控的润湿过程，更方便和成本有效的生产等。此外，使用 这种非常高浓度的渗透压增加化合物在润湿液体中已被证明是非常有效的。

公开(公告)号：US20120165790A1

公开(公告)日：2012-06-28

申请号：US13331485

申请日：2011-12-20

申请人： Evelina GUSTAVSSON ,  Jan UTAS

发明人： Evelina GUSTAVSSON ,  Jan UTAS

IPC分类号： A61M27/00 ,  B32B37/06

CPC分类号： A61M25/002 ,  A61M25/0017 ,  A61M25/0111 ,  B65B53/02

摘要： A catheter assembly is disclosed, comprising a catheter, such as a urinary catheter, which at least a partly is provided with a hydrophilic coating. The catheter assembly further comprises a wetting fluid. The receptacle is in direct contact with the hydrophilic coating of the catheter over essentially the entire length of the part of the catheter being provided with the hydrophilic coating. This may e.g. be achieved by using a shrink wrap material. In order to accomplish adequate wetting, channels or the like may be provided on the inner surface of the receptacle or the outer surface of the catheter.

摘要翻译： 公开了一种导管组件，其包括诸如导尿管的导管，其至少部分地设置有亲水性涂层。 导管组件还包括润湿流体。 容器与导管的亲水性涂层直接接触，在导尿管的整个部分的整个长度上提供有亲水性涂层。 这可以例如 通过使用收缩包装材料来实现。 为了实现充分的润湿，可以在容器的内表面或导管的外表面上设置通道等。

公开(公告)号：US07066912B2

公开(公告)日：2006-06-27

申请号：US10168091

申请日：2000-12-18

申请人： Daniel Nestenborg ,  Jan Utas ,  Agneta Pettersson

发明人： Daniel Nestenborg ,  Jan Utas ,  Agneta Pettersson

IPC分类号： A61M5/00 ,  A61M5/32 ,  A61M27/00 ,  A61F5/44

CPC分类号： A61M25/002 ,  A61M2025/0062

摘要： A wetting apparatus (1) for wetting a hydrophilic urinary catheter (3), comprising: a wetting fluid container (4) containing a wetting fluid and being openable by the application of a pulling force thereto; a wetting receptacle (2); and a hydrophilic urinary catheter (3) to be wetted by said wetting fluid and being arranged within said wetting receptacle (2). The wetting fluid container (4) is arranged within the wetting receptacle (2), and the wetting receptacle is extendable, for opening the wetting container without rupturing a sealed condition of the wetting receptacle.

摘要翻译： 一种用于润湿亲水性导尿管（3）的润湿装置（1），包括：润湿流体容器（4），其包含润湿流体并且可通过向其施加拉力而打开; 润湿容器（2）; 以及被所述润湿流体润湿并设置在所述润湿容器（2）内的亲水性导尿管（3）。 润湿流体容器（4）布置在润湿容器（2）内，并且润湿容器可延伸，用于打开润湿容器而不破坏润湿容器的密封状态。

公开(公告)号：US6065597A

公开(公告)日：2000-05-23

申请号：US875345

申请日：1997-07-29

申请人： Agneta Pettersson ,  Jan Utas

发明人： Agneta Pettersson ,  Jan Utas

IPC分类号： A61B19/02 ,  A61M25/00 ,  B65D77/04 ,  B65D81/20 ,  B65D83/10

CPC分类号： A61M25/0111 ,  A61M25/002

摘要： A catheter package (10; 110; 210) comprising a catheter (1; 101; 201) positioned within an inner container (2; 102; 202) permeable to a sterilizing agent, for example an ethylene oxide gas. An outer container (3; 103; 203) which prevents access of moisture to the interior thereof encloses the inner container and catheter assembly. Two or more catheters may be stored in individual inner containers within the outer container.

摘要翻译： PCT No.PCT / SE97 / 01033 Sec。 371日期1997年7月29日第 102（e）日期1997年7月29日PCT提交1997年6月12日PCT公布。 公开号WO97 / 47349 日期1997年12月18日一种导管包装（10; 110; 210），其包括位于可通过灭菌剂例如环氧乙烷气体的内容器（2; 102; 202）内的导管（1; 101; 201）。 防止湿气进入其内部的外部容器（3; 103; 203）包围内部容器和导管组件。 两个或更多个导管可以存储在外部容器内的各个内部容器中。

公开(公告)号：US20120191073A1

公开(公告)日：2012-07-26

申请号：US13438457

申请日：2012-04-03

申请人： Jan UTAS ,  Fredrik ANDERSSON

发明人： Jan UTAS ,  Fredrik ANDERSSON

IPC分类号： A61M27/00

CPC分类号： A61L29/049 ,  A61L29/14

摘要： A medical device is disclosed, comprising a substrate, having on its surface, on at least a part thereof, a hydrophilic surface layer providing low-friction surface character of the medical device when wetted by a wetting fluid. The substrate is made of a polymer blend comprising a polyolefin and a composition having molecules with active hydrogen(s), such as polyamide or polyurethane. The hydrophilic surface layer is preferably adhered to the substrate by a polyurea network, whereby said polyurea network forms a covalent bond to said active hydrogen(s) in the substrate. The new substrate material is environmentally acceptable and cost effective, has adequate mechanical and chemical properties and enables the hydrophilic coating to be adequately adhered.

摘要翻译： 公开了一种医疗装置，其包括基底，其表面上至少有一部分具有亲水性表面层，当润湿流体润湿时，其提供医疗装置的低摩擦表面特性。 基底由包含聚烯烃和具有活性氢分子（如聚酰胺或聚氨酯）的组合物的聚合物共混物制成。 亲水性表面层优选通过聚脲网络粘合到基底上，由此所述聚脲网络与基底中的所述活性氢形成共价键。 新的基底材料是环境可接受的并且具有成本效益，具有足够的机械和化学性质，并且能够使亲水涂层充分粘附。

公开(公告)号：US08168249B2

公开(公告)日：2012-05-01

申请号：US11488099

申请日：2006-07-18

申请人： Jan Utas ,  Fredrik Andersson

发明人： Jan Utas ,  Fredrik Andersson

IPC分类号： A41D19/00 ,  A61M1/00 ,  A61M27/00 ,  B05D3/00

CPC分类号： A61L29/049 ,  A61L29/14

摘要： A medical device is disclosed, comprising a substrate, having on its surface, on at least a part thereof, a hydrophilic surface layer providing low-friction surface character of the medical device when wetted by a wetting fluid. The substrate is made of a polymer blend comprising a polyolefin and a composition having molecules with active hydrogen(s), such as polyamide or polyurethane. The hydrophilic surface layer is preferably adhered to the substrate by a polyurea network, whereby said polyurea network forms a covalent bond to said active hydrogen(s) in the substrate. The new substrate material is environmentally acceptable and cost effective, has adequate mechanical and chemical properties and enables the hydrophilic coating to be adequately adhered.

摘要翻译： 公开了一种医疗装置，其包括基底，其表面上至少有一部分具有亲水性表面层，当润湿流体润湿时，其提供医疗装置的低摩擦表面特性。 基底由包含聚烯烃和具有活性氢分子（如聚酰胺或聚氨酯）的组合物的聚合物共混物制成。 亲水性表面层优选通过聚脲网络粘合到基底上，由此所述聚脲网络与基底中的所述活性氢形成共价键。 新的基底材料是环境可接受的并且具有成本效益，具有足够的机械和化学性质，并且能够使亲水涂层充分粘附。

公开(公告)号：US20070016169A1

公开(公告)日：2007-01-18

申请号：US11488099

申请日：2006-07-18

申请人： Jan Utas ,  Fredrik Andersson

发明人： Jan Utas ,  Fredrik Andersson

IPC分类号： A61L33/00 ,  B05D3/00

CPC分类号： A61L29/049 ,  A61L29/14

摘要： A medical device is disclosed, comprising a substrate, having on its surface, on at least a part thereof, a hydrophilic surface layer providing low-friction surface character of the medical device when wetted by a wetting fluid. The substrate is made of a polymer blend comprising a polyolefin and a composition having molecules with active hydrogen(s), such as polyamide or polyurethane. The hydrophilic surface layer is preferably adhered to the substrate by a polyurea network, whereby said polyurea network forms a covalent bond to said active hydrogen(s) in the substrate. The new substrate material is environmentally acceptable and cost effective, has adequate mechanical and chemical properties and enables the hydrophilic coating to be adequately adhered.

摘要翻译： 公开了一种医疗装置，其包括基底，其表面上至少有一部分具有亲水性表面层，当润湿流体润湿时，其提供医疗装置的低摩擦表面特性。 基底由包含聚烯烃和具有活性氢分子（如聚酰胺或聚氨酯）的组合物的聚合物共混物制成。 亲水性表面层优选通过聚脲网络粘合到基底上，由此所述聚脲网络与基底中的所述活性氢形成共价键。 新的基底材料是环境可接受的并且具有成本效益，具有足够的机械和化学性质，并且能够使亲水涂层充分粘附。