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公开(公告)号:US20130090478A1
公开(公告)日:2013-04-11
申请号:US13690041
申请日:2012-11-30
发明人: HENRY J. BRESLIN , CHAOZHONG CAI , WEI HE , ROBERT W. KAVASH
IPC分类号: C07D233/64 , C07D275/06
CPC分类号: A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
摘要翻译: 本发明涉及式(I)的新型阿片受体调节剂。 本发明还涉及制备这些化合物的方法,含有这些化合物的药物组合物,以及它们在治疗可通过调节阿片类受体而改善或治疗的病症中的用途。
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公开(公告)号:US09205076B2
公开(公告)日:2015-12-08
申请号:US14282828
申请日:2014-05-20
发明人: Henry J. Breslin , Chaozhong Cai , Wei He , Robert W. Kavash
IPC分类号: A61K31/4174 , C07D233/64 , C07D275/06
CPC分类号: A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
摘要翻译: 本发明涉及式(I)的新型阿片受体调节剂。 本发明还涉及制备这些化合物的方法,含有这些化合物的药物组合物,以及它们在治疗可通过调节阿片类受体而改善或治疗的病症中的用途。
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公开(公告)号:US20140256779A1
公开(公告)日:2014-09-11
申请号:US14282828
申请日:2014-05-20
发明人: Henry J. Breslin , Chaozhong Cai , Wei He , Robert W. Kavash
IPC分类号: C07D233/64
CPC分类号: A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
摘要翻译: 本发明涉及式(I)的新型阿片受体调节剂。 本发明还涉及制备这些化合物的方法,含有这些化合物的药物组合物,以及它们在治疗可通过调节阿片类受体而改善或治疗的病症中的用途。
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公开(公告)号:US08772325B2
公开(公告)日:2014-07-08
申请号:US14045008
申请日:2013-10-03
发明人: Henry J. Breslin , Chaozhong Cai , Wei He , Robert W. Kavash
IPC分类号: A61K31/4174 , C07D233/64
CPC分类号: A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
摘要翻译: 本发明涉及式(I)的新型阿片受体调节剂。 本发明还涉及制备这些化合物的方法,含有这些化合物的药物组合物,以及它们在治疗可通过调节阿片类受体而改善或治疗的病症中的用途。
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公开(公告)号:US20140039024A1
公开(公告)日:2014-02-06
申请号:US14045008
申请日:2013-10-03
发明人: HENRY J. BRESLIN , CHAOZHONG CAI , WEI HE , ROBERT W. KAVASH
IPC分类号: C07D233/64
CPC分类号: A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
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公开(公告)号:US08609709B2
公开(公告)日:2013-12-17
申请号:US13690041
申请日:2012-11-30
发明人: Henry J. Breslin , Chaozhong Cai , Wei He , Robert W. Kavash
IPC分类号: A61K31/4174 , A61K31/4178 , C07D233/64
CPC分类号: A61K31/4164 , A61K9/20 , A61K9/2806 , A61K31/4174 , C07D233/64 , C07D275/06
摘要: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.
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