公开(公告)号：US12103962B2

公开(公告)日：2024-10-01

申请号：US15117360

申请日：2014-12-19

申请人： Janssen Pharmaceuticals, Inc.

发明人： Eszter Nagy ,  Gábor Nagy ,  Valéria Szijárto ,  Luis Guachalla ,  Maximiliano Vasquez

IPC分类号： C07K16/12 ,  A61K39/00 ,  G01N33/569 ,  G01N33/92

CPC分类号： C07K16/1232 ,  G01N33/56916 ,  G01N33/92 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/245 ,  G01N2400/50

摘要： The invention refers to an isolated antibody that specifically binds to O25b antigen of E. coli strains comprising at least an antibody heavy chain variable region (VH), which comprises any of the CDR1 to CDR3 sequences as listed in FIG. 1, and optionally further comprising an antibody light chain variable region (VL), which comprises any of the CDR4 to CDR6 sequences as listed in FIG. 1, or functionally active CDR variants of any of the forgoing CDR 1-6 sequences.

公开(公告)号：US12102445B2

公开(公告)日：2024-10-01

申请号：US17068865

申请日：2020-10-13

申请人： Janssen Pharmaceuticals, Inc.

发明人： Frederick E. Shelton, IV ,  Monica A. Kapil ,  Emma L. Hubert ,  Jason L. Harris

IPC分类号： A61B5/00 ,  A61B5/0205 ,  A61B5/11 ,  A61B5/145 ,  A61M5/172 ,  A61M5/20 ,  A61M15/00 ,  A61M15/08 ,  G16H10/60 ,  G16H20/10 ,  G16H20/30 ,  G16H20/40 ,  G16H20/60 ,  G16H40/20 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H70/40 ,  H04W12/02 ,  H04W12/0431 ,  A61B5/021 ,  A61B5/024

CPC分类号： A61B5/4839 ,  A61B5/0022 ,  A61B5/02055 ,  A61B5/1101 ,  A61B5/1112 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/4266 ,  A61B5/4866 ,  A61M5/1723 ,  A61M5/2033 ,  A61M15/0065 ,  A61M15/08 ,  G16H10/60 ,  G16H20/10 ,  G16H20/30 ,  G16H20/40 ,  G16H20/60 ,  G16H40/20 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H70/40 ,  H04W12/02 ,  H04W12/0431 ,  A61B5/021 ,  A61B5/024 ,  A61B2560/0242 ,  A61M2205/3317 ,  A61M2205/3327 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/04 ,  A61M2230/20 ,  A61M2230/201 ,  A61M2230/50 ,  A61M2230/63

摘要： In general, systems and methods for monitoring and communicating information using drug administration devices are provided.

公开(公告)号：US20240316003A1

公开(公告)日：2024-09-26

申请号：US18679720

申请日：2024-05-31

申请人： Janssen Pharmaceuticals, Inc.

发明人： Philippe Fernandes ,  Mark Schmidt ,  Vanina Popova ,  Adam Savitz ,  Rama Melkote ,  Wayne C. Drevets ,  Srihari Gopal ,  Darrel Pemberton ,  Chakradhar Lagishetty ,  Iva Kezic

IPC分类号： A61K31/40 ,  A61P25/24

CPC分类号： A61K31/40 ,  A61P25/24 ,  C07B2200/13

摘要： The disclosure provides crystalline and amorphous forms of aticaprant. Also provided by the disclosure are pharmaceutical compositions comprising the amorphous or crystalline forms, methods of treating major depressive disorder using the amorphous or crystalline forms of aticaprant, amorphous or crystalline forms of aticaprant for use in the treatment of major depressive disorder in a human patient having anhedonia, uses of the amorphous or crystalline forms of aticaprant in the manufacture of a medicament for the treatment of major depressive disorder, and packages or pharmaceutical products comprising (i) amorphous or crystalline forms of aticaprant and (ii) instructions for treating major depressive disorder. In some aspects, the human patient treated as described herein has anhedonia.

公开(公告)号：US20240294582A1

公开(公告)日：2024-09-05

申请号：US18655708

申请日：2024-05-06

申请人： Janssen Pharmaceuticals, Inc.

发明人： Jan GRIJPSTRA ,  Marleen Eveline WEERDENBURG ,  Jeroen GEURTSEN ,  Cristhina Kellen FAE ,  Jakob Louris FEITSMA

IPC分类号： C07K14/195 ,  A61K39/02 ,  A61K39/108 ,  C07K14/245 ,  C07K16/12

CPC分类号： C07K14/195 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/0266 ,  C07K14/245 ,  C07K16/1232

摘要： Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

公开(公告)号：US12076385B2

公开(公告)日：2024-09-03

申请号：US17934781

申请日：2022-09-23

申请人： Glaxosmithkline Biologicals S.A. ,  Janssen Pharmaceuticals, Inc.

发明人： Jan Theunis Poolman ,  Bert Jacquemyn ,  Darren Robert Abbanat ,  Patricia Ibarra Yon ,  Peter Wilhelmus Maria Hermans ,  Michael Thomas Kowarik ,  Michael Lukas Wetter ,  Stefan Jochen Kemmler ,  Micha Andres Häuptle ,  Veronica Gambillara Fonck ,  Manuela Mally

IPC分类号： A61K39/02 ,  A61K39/108 ,  A61K39/385 ,  A61K47/64 ,  A61P31/04 ,  C08B37/00 ,  A61K39/00

CPC分类号： A61K39/0258 ,  A61K39/385 ,  A61K47/6415 ,  A61K47/646 ,  A61P31/04 ,  C08B37/0063 ,  A61K2039/545 ,  A61K2039/55583 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/70 ,  Y02A50/30

摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.

公开(公告)号：US12070587B2

公开(公告)日：2024-08-27

申请号：US16585500

申请日：2019-09-27

申请人： Janssen Pharmaceuticals, Inc.

发明人： Hung Mach

IPC分类号： A61M5/315 ,  G09B23/28 ,  A61M5/20 ,  A61M5/32

CPC分类号： A61M5/31573 ,  A61M5/31528 ,  A61M5/3158 ,  G09B23/285 ,  A61M2005/2086 ,  A61M2005/3247 ,  A61M2205/581 ,  A61M2205/586

摘要： An injection device and an injection device trainer for training a user to use an injection device. Each one of the injection device and the injection device trainer can include: a body portion; and an actuator positioned towards a proximal end of the body portion, the actuator moveable from a proximal position to a distal position; wherein the body portion comprises a body protrusion and the actuator comprises a latch that is arranged to couple with the body protrusion when the actuator is in the distal position, thus holding the actuator in the distal position.

公开(公告)号：US20240209379A1

公开(公告)日：2024-06-27

申请号：US18498448

申请日：2023-10-31

申请人： Janssen Pharmaceuticals, Inc.

发明人： Kurt Iver KAMRUD ,  Maung Nyan WIN ,  Nathaniel Stephen WANG ,  Jason L. DEHART

IPC分类号： C12N15/63 ,  A61K48/00 ,  C12N15/113 ,  C12N15/85 ,  C12N15/86

CPC分类号： C12N15/63 ,  A61K48/005 ,  C12N15/113 ,  C12N15/86 ,  C07K2319/50 ,  C12N2015/8518 ,  C12N2310/531 ,  C12N2770/00042 ,  C12N2770/36062 ,  C12N2770/36111 ,  C12N2770/36143 ,  C12N2830/30 ,  C12N2840/105

摘要： The present disclosure generally relates to nucleic acid molecules for use in regulating gene expression. Disclosed herein include nucleic acid molecules containing one or more structural elements of the viral capsid enhancer operably linked to a coding sequence of a gene of interest. In some embodiments, the viral capsid enhancer comprises a Downstream Loop (DLP) from a viral capsid protein, or a variant of the DLP.

公开(公告)号：US11958889B2

公开(公告)日：2024-04-16

申请号：US16757621

申请日：2018-10-24

申请人： Janssen Pharmaceuticals, Inc. ,  AC Immune SA

发明人： Elizabeth Anne Ramsburg ,  Donata de Marco ,  Charlotte Sadaka ,  Jaap Goudsmit ,  Andreas Muhs ,  Maria Pihlgren Bosch ,  Marija Vukicevic Verhille ,  David Hickman ,  Nicolas Piot ,  Saroj Raj Ghimire

IPC分类号： C07K14/47 ,  A61K9/127 ,  A61K38/17 ,  A61K39/00 ,  A61K39/39 ,  A61P25/28

CPC分类号： C07K14/4711 ,  A61K9/127 ,  A61K9/1271 ,  A61K38/1709 ,  A61K39/0007 ,  A61K39/39 ,  A61P25/28 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/6018 ,  A61K2039/627

摘要： Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.

公开(公告)号：US11915608B2

公开(公告)日：2024-02-27

申请号：US16585544

申请日：2019-09-27

申请人： Janssen Pharmaceuticals, Inc.

发明人： Hung Mach

IPC分类号： G09B23/28 ,  G16H20/17 ,  A61M5/315 ,  A61M5/32 ,  G09B9/00

CPC分类号： G09B23/285 ,  A61M5/31586 ,  A61M5/3202 ,  A61M5/3243 ,  G09B9/00 ,  G16H20/17

摘要： An injection device and an injection device trainer for training a user to use an injection device. Each one of the injection device and the injection device trainer can include: a body portion; an actuator positioned towards a proximal end of the body portion, the actuator moveable from a proximal position to a distal position; a shield positioned towards a distal end of the body portion, the shield moveable between: an initial position; an extended position that is more distal relative to the body portion than the initial position; and a connector that connects the actuator to the shield such that movement of the actuator from the distal position towards the proximal position pulls the shield from the extended position to the initial position.

公开(公告)号：US20230310481A1

公开(公告)日：2023-10-05

申请号：US17996083

申请日：2021-04-13

申请人： JANSSEN PHARMACEUTICALS, INC.

发明人： Tim Hugo Maria JONCKERS ,  Frederik PAUWELS ,  Yannick DEBING

IPC分类号： A61K31/7076 ,  A61P31/14

CPC分类号： A61K31/7076 ,  A61P31/14

摘要： The present disclosure is directed toward bi- and monocyclic nucleoside analogs, and compositions comprising these compounds for use in the treatment of hepatitis E infections.