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    Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
    2.
    发明授权
    Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes 有权
    取代的氨基哌啶作为二肽基肽酶-IV抑制剂用于治疗糖尿病

    公开(公告)号：US08716482B2

    公开(公告)日：2014-05-06

    申请号：US13390708

    申请日：2010-09-15

    申请人： Jason M. Cox ,  Tesfaye Biftu ,  Hong Dong Chu ,  Danqing Feng ,  Ann E. Weber

    发明人： Jason M. Cox ,  Tesfaye Biftu ,  Hong Dong Chu ,  Danqing Feng ,  Ann E. Weber

    IPC分类号： C07D211/32 ,  A61K31/00

    CPC分类号： C07D487/04 ,  C07D519/00

    摘要： The present invention is directed to novel substituted aminopiperidines of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-ÏV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及结构式I的新型取代氨基哌啶，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-κV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Fused aminopiperidines as dipeptidyi peptidase-IV inhibitors for the treatment or prevention of diabetes
    5.
    发明授权
    Fused aminopiperidines as dipeptidyi peptidase-IV inhibitors for the treatment or prevention of diabetes 有权
    作为二肽基肽酶-IV抑制剂的熔融氨基哌啶用于治疗或预防糖尿病

    公开(公告)号：US08017624B2

    公开(公告)日：2011-09-13

    申请号：US11990037

    申请日：2006-08-22

    申请人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    发明人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    IPC分类号： A61K31/437 ,  C07D487/04

    CPC分类号： C07D471/14

    摘要： The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新型取代的稠合氨基哌啶，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes
    6.
    发明授权
    Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes 有权
    融合氨基哌啶作为二肽基肽酶-4抑制剂用于治疗或预防糖尿病

    公开(公告)号：US07943615B2

    公开(公告)日：2011-05-17

    申请号：US12085797

    申请日：2006-12-08

    申请人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    发明人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    IPC分类号： C07D487/22 ,  A61K31/519

    CPC分类号： C07D471/14

    摘要： The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-4 enzyme is involved.

    摘要翻译： 本发明涉及结构式（I）的新型取代的稠合氨基哌啶，其是二肽基肽酶-4酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-4酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-4酶的疾病中的用途。

    Fused Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
    8.
    发明申请
    Fused Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 有权
    融合的氨基哌啶作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US20090258894A1

    公开(公告)日：2009-10-15

    申请号：US11990037

    申请日：2006-08-22

    申请人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    发明人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    IPC分类号： A61K31/4375 ,  C07D471/14

    CPC分类号： C07D471/14

    摘要： The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新型取代的稠合氨基哌啶，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。