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公开(公告)号:US20130059834A1
公开(公告)日:2013-03-07
申请号:US13600863
申请日:2012-08-31
申请人: Shaoqing Chen , Javier de Vicente Fidalgo , Matthew Michael Hamilton , Johannes Cornelius Hermann , Joshua Kennedy-Smith , Hongju Li , Allen John Lovey , Matthew C. Lucas , Kin-Chun Thomas Luk , Stephen M. Lynch , Counde O'yang , Fernando Padilla , Ryan Craig Schoenfeld , Achyutharao Sidduri , Michael Soth , Ce Wang , Peter Michael Wovkulich , Xiaohu Zhang
发明人: Shaoqing Chen , Javier de Vicente Fidalgo , Matthew Michael Hamilton , Johannes Cornelius Hermann , Joshua Kennedy-Smith , Hongju Li , Allen John Lovey , Matthew C. Lucas , Kin-Chun Thomas Luk , Stephen M. Lynch , Counde O'yang , Fernando Padilla , Ryan Craig Schoenfeld , Achyutharao Sidduri , Michael Soth , Ce Wang , Peter Michael Wovkulich , Xiaohu Zhang
IPC分类号: A61K31/4985 , C07D491/107 , A61K31/5377 , C07D471/04 , C07D495/04 , A61P29/00 , A61P31/00 , A61P37/02 , A61P37/06 , A61P9/00 , A61P3/10 , A61P19/02 , A61P11/06 , A61P25/00 , A61P25/28 , A61P17/06 , A61P17/00 , A61P35/00 , A61P35/02 , A61P1/04 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途,其中所述变量如本文所述定义,其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号:US20100021423A1
公开(公告)日:2010-01-28
申请号:US12460658
申请日:2009-07-22
申请人: Kenneth Albert Brameld , David Scott Carter , Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Eric Brian Sjogren , Francisco Xavier Talamas
发明人: Kenneth Albert Brameld , David Scott Carter , Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Eric Brian Sjogren , Francisco Xavier Talamas
IPC分类号: A61K38/20 , A61K38/21 , C12N5/02 , A61K38/17 , A61K31/4412 , C07D213/63
CPC分类号: C07D213/64 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/10 , C07D409/10 , C07D413/10
摘要: Compounds having the formula I wherein R1, R2, R3, R4a, R4b, R4c, R5, R6, R9 and n are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译: 具有式I的化合物,其中R1,R2,R3,R4a,R4b,R4c,R5,R6,R9和n如本文所定义,是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号:US08273773B2
公开(公告)日:2012-09-25
申请号:US12460658
申请日:2009-07-22
申请人: Kenneth Albert Brameld , David Scott Carter , Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Eric Brian Sjogren , Francisco Xavier Talamas
发明人: Kenneth Albert Brameld , David Scott Carter , Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Eric Brian Sjogren , Francisco Xavier Talamas
IPC分类号: A61K31/4412 , C07D213/64
CPC分类号: C07D213/64 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/10 , C07D409/10 , C07D413/10
摘要: Compounds having the formula I wherein R1, R2, R3, R4a, R4b, R4c, R5, R6, R9 and n are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译: 具有式I的化合物,其中R1,R2,R3,R4a,R4b,R4c,R5,R6,R9和n如本文所定义,是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号:US08658646B2
公开(公告)日:2014-02-25
申请号:US13600863
申请日:2012-08-31
申请人: Shaoqing Chen , Javier de Vicente Fidalgo , Matthew Michael Hamilton , Johannes Cornelius Hermann , Joshua Kennedy-Smith , Hongju Li , Allen John Lovey , Matthew C. Lucas , Kin-Chun Thomas Luk , Stephen M. Lynch , Counde O'yang , Fernando Padilla , Ryan Craig Schoenfeld , Achyutharao Sidduri , Michael Soth , Ce Wang , Peter Michael Wovkulich , Xiaohu Zhang
发明人: Shaoqing Chen , Javier de Vicente Fidalgo , Matthew Michael Hamilton , Johannes Cornelius Hermann , Joshua Kennedy-Smith , Hongju Li , Allen John Lovey , Matthew C. Lucas , Kin-Chun Thomas Luk , Stephen M. Lynch , Counde O'yang , Fernando Padilla , Ryan Craig Schoenfeld , Achyutharao Sidduri , Michael Soth , Ce Wang , Peter Michael Wovkulich , Xiaohu Zhang
IPC分类号: A61K31/495
CPC分类号: C07D487/04
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途,其中所述变量如本文所述定义,其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号:US20100330032A1
公开(公告)日:2010-12-30
申请号:US12822630
申请日:2010-06-24
申请人: Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Alfred Sui-Ting Lui , Kristen Lynn McCaleb , Ryan Craig Schoenfeld , Francisco Xavier Talamas
发明人: Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Alfred Sui-Ting Lui , Kristen Lynn McCaleb , Ryan Craig Schoenfeld , Francisco Xavier Talamas
IPC分类号: A61K38/20 , C07D239/10 , A61K31/513 , C07C311/51 , A61K31/18 , C07D233/74 , A61K31/4166 , C07D213/64 , A61K31/4418 , C07C63/74 , A61K31/192 , C07C69/78 , A61K31/24 , A61K38/21 , A61K38/17 , A61P31/12 , C12N5/02
CPC分类号: C07D239/10 , C07D207/26 , C07D207/44 , C07D233/34 , C07D237/14 , C07D239/36 , C07D241/18 , C07D249/12 , C07D275/06 , C07D285/16
摘要: Compounds having the formula I wherein R1, R2, R3, R4, and R5 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译: 具有式I的化合物,其中R 1,R 2,R 3,R 4和R 5如本文所定义,是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号:US08158631B2
公开(公告)日:2012-04-17
申请号:US12822630
申请日:2010-06-24
申请人: Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Alfred Sui-Ting Lui , Kristen Lynn McCaleb , Ryan Craig Schoenfeld , Francisco Xavier Talamas
发明人: Elbert Chin , Javier de Vicente Fidalgo , Jim Li , Alfred Sui-Ting Lui , Kristen Lynn McCaleb , Ryan Craig Schoenfeld , Francisco Xavier Talamas
IPC分类号: A61K31/497 , C07D241/02
CPC分类号: C07D239/10 , C07D207/26 , C07D207/44 , C07D233/34 , C07D237/14 , C07D239/36 , C07D241/18 , C07D249/12 , C07D275/06 , C07D285/16
摘要: Compounds having the formula I wherein R1, R2, R3, R4, and R5 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译: 具有式I的化合物,其中R 1,R 2,R 3,R 4和R 5如本文所定义,是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号:US20110300103A1
公开(公告)日:2011-12-08
申请号:US13212742
申请日:2011-08-18
申请人: Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Francisco Xavier Talamas , Joshua Paul Gergely Taygerly
发明人: Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Francisco Xavier Talamas , Joshua Paul Gergely Taygerly
IPC分类号: A61K31/4709 , A61K31/513 , A61K31/501 , A61K31/4439 , A61P31/14 , A61K31/502 , A61K38/21 , A61K38/20 , A61K38/19 , C12N5/00 , A61K31/498 , A61K31/4725
CPC分类号: C07D403/10 , C07D213/69 , C07D239/46 , C07D401/04 , C07D401/10 , C07D401/14
摘要: Method for treating an HCV infection and inhibiting HCV replication with a compound of formula I wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein
摘要翻译: 用式I化合物治疗HCV感染和抑制HCV复制的方法,其中R 1,R 2,R 3,R 4,X 1,X 2,X 3和X 4如本文所定义
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公开(公告)号:US08026253B2
公开(公告)日:2011-09-27
申请号:US12797308
申请日:2010-06-09
申请人: Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Francisco Xavier Talamas , Joshua Paul Gergely Taygerly
发明人: Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Francisco Xavier Talamas , Joshua Paul Gergely Taygerly
IPC分类号: A61K31/47
CPC分类号: C07D403/10 , C07D213/69 , C07D239/46 , C07D401/04 , C07D401/10 , C07D401/14
摘要: Compounds having the formula I wherein wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译: 具有式I的化合物,其中R 1,R 2,R 3,R 4,X 1,X 2,X 3和X 4如本文所定义是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号:US08618103B2
公开(公告)日:2013-12-31
申请号:US12878048
申请日:2010-09-09
申请人: Javier de Vicente Fidalgo , Johannes Cornelius Hermann , Remy Lemoine , Hongju Li , Allen John Lovey , Eric Brian Sjogren , Michael Soth
发明人: Javier de Vicente Fidalgo , Johannes Cornelius Hermann , Remy Lemoine , Hongju Li , Allen John Lovey , Eric Brian Sjogren , Michael Soth
IPC分类号: C07D487/04 , A61K31/4985 , C07D239/04 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号: C07D487/04 , C07D513/04
摘要: The present invention relates to the use of novel compounds of Formula I, wherein the variables m, n, p, q, Q, r, R, R′, X, X′, Y, Z1, Z2, and Z3 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新化合物的用途,其中变量m,n,p,q,Q,r,R,R',X,X',Y,Z 1,Z 2和Z 3定义为 其抑制JAK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号:US08487103B2
公开(公告)日:2013-07-16
申请号:US13212742
申请日:2011-08-18
申请人: Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Francisco Xavier Talamas , Joshua Paul Gergely Taygerly
发明人: Javier de Vicente Fidalgo , Jim Li , Ryan Craig Schoenfeld , Francisco Xavier Talamas , Joshua Paul Gergely Taygerly
IPC分类号: C07D215/00
CPC分类号: C07D403/10 , C07D213/69 , C07D239/46 , C07D401/04 , C07D401/10 , C07D401/14
摘要: Method for treating an HCV infection and inhibiting HCV replication with a compound of formula I wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein
摘要翻译: 用式I化合物治疗HCV感染和抑制HCV复制的方法,其中R 1,R 2,R 3,R 4,X 1,X 2,X 3和X 4如本文所定义
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