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公开(公告)号：US08349303B1
公开(公告)日：2013-01-08
申请号：US12758860
申请日：2010-04-13
IPC分类号： A61K31/74
CPC分类号： C11D3/0078 , C11D3/3723
摘要： A topical pharmaceutical composition comprising a pharmaceutical active and a polymer of general formula I or general formula II wherein Ck is a saturated or unsaturated, five, six or seven-membered ring; R is a C1-C3alkyl; n is 1, 2, 3, 4 or 5 and m provides a number average molecular weight of the polymer of from 2000 to 80,000.
摘要翻译： 一种局部药物组合物，其包含药物活性物质和通式I或通式II的聚合物，其中Ck为饱和或不饱和的，5,6或7元环; R是C1-C3烷基; n为1,2,3,4或5，并且m提供的聚合物的数均分子量为2000至80,000。
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公开(公告)号：US08133512B2
公开(公告)日：2012-03-13
申请号：US12459779
申请日：2009-07-08
CPC分类号： A61K9/0051 , A61K47/34
摘要： Matrix controlled diffusion drug delivery systems based on one or more silicon-containing monomers of the general formula: wherein L, X−, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.
摘要翻译： 基于一种或多种以下通式的含硅单体的基质控制扩散药物递送系统：其中L，X-，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和V如本文所述。
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公开(公告)号：US08083348B2
公开(公告)日：2011-12-27
申请号：US12456420
申请日：2009-06-16
CPC分类号： G02B1/043 , C08F20/56 , C08F26/08 , C08F118/02 , C08F226/02 , C08L81/00 , C08L83/10
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising an ethylenically unsaturated-containing non-amphiphilic macromonomer comprising hydrophilic units or hydrophobic units derived from a living radical polymerization of one or more ethylenically unsaturated hydrophilic monomers or one or more ethylenically unsaturated hydrophobic monomers are disclosed.
摘要翻译： 生物医学装置，例如由含有烯键式不饱和的非两亲性大分子单体的混合物的聚合产物形成的隐形眼镜，其包含亲水单元或衍生自一种或多种烯属不饱和亲水单体的活性自由基聚合的疏水单元或一种或多种烯属不饱和单体 公开疏水单体。
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公开(公告)号：US07994356B2
公开(公告)日：2011-08-09
申请号：US12499854
申请日：2009-07-09
CPC分类号： C08G77/50 , C07F7/0838 , C08G77/20
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.
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公开(公告)号：US20110146206A1
公开(公告)日：2011-06-23
申请号：US13039912
申请日：2011-03-03
IPC分类号： B65B55/02 , C08F222/14 , G02C7/04
CPC分类号： C08G77/388 , G02B1/043 , C08L83/08
摘要： This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.
摘要翻译： 本申请涉及一种改进的合成阳离子硅氧烷预聚物的方法以及具有改进的与单官能硅氧烷基甲基丙烯酸酯单体的相容性和含有阳离子硅氧烷预聚物的医疗装置的特异性阳离子硅氧烷预聚物。
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6.发明申请Trimethylsilyl-Capped Polysiloxane Macromonomers Containing Polar Fluorinated Side-Chains 审中-公开含有极性氟化侧链的三甲基甲硅烷基封端的聚硅氧烷大分子单体公开(公告)号：US20090168013A1
公开(公告)日：2009-07-02
申请号：US12269442
申请日：2008-11-12
IPC分类号： G02C7/04 , C07F7/02 , C08F290/06
CPC分类号： C08F290/068 , C08G77/20 , C08G77/385 , G02B1/043 , C08L51/085
摘要： A method for reducing the modulus of polymer siloxane hydrogel compositions by employing monomeric polysiloxanes endcapped with trimethylsilyl to reduce the crosslinking density of the hydrogel. The synthesis consists of a single vessel acid catalyzed ring opening polymerization and may be employed to produce copolymers useful as hydrogel contact lens materials.
摘要翻译： 通过使用用三甲基甲硅烷基封端的单体聚硅氧烷降低聚合物硅氧烷水凝胶组合物的模量以降低水凝胶的交联密度的方法。 该合成由单容器酸催化的开环聚合组成，可用于产生可用作水凝胶隐形眼镜材料的共聚物。
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公开(公告)号：US20090143858A1
公开(公告)日：2009-06-04
申请号：US11948298
申请日：2007-11-30
申请人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
发明人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
CPC分类号： A61F2/1613 , A61B18/20 , A61F2/14 , A61F2/16 , A61F2/1627 , A61F2/1635 , B29D11/00461 , B29D11/023 , C08J7/12 , C08J7/123 , G02C2202/14
摘要： A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.
摘要翻译： 用于改变光学聚合物材料的折射率的方法。 该方法包括用具有0.05nJ至1000nJ的脉冲能量的聚焦，可见或近红外激光照射光学聚合物材料的选择区域。 照射导致折射光学结构的形成，其特征在于折射率的变化，显示很少或没有散射损失，并且在拉曼光谱方面相对于未照射的光学聚合物材料没有显着差异。 该方法可以用于在人眼中手术植入人工晶状体后修改眼内透镜的折射率。 本发明还涉及一种包括折射光学结构的光学器件，其中折射结构的特征在于折射率的变化，表现出很少的或没有散射损耗，并且在拉曼光谱方面相对于未辐照的表现没有显着的差异 光学，聚合材料。
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公开(公告)号：US20090142485A1
公开(公告)日：2009-06-04
申请号：US12273192
申请日：2008-11-18
IPC分类号： B05D5/06
CPC分类号： G02B1/043 , A61L27/18 , A61L27/34 , B29D11/00067 , C08L83/04
摘要： A process for treating a silicone hydrogel biomedical device, especially an ophthalmic lens such as a contact lens, involves: immersing the silicone hydrogel biomedical device with a mixture of an organic solvent and a hydrophilic, polymeric material, for a sufficient time that the device is swollen in volume by at least 30%; and removing the organic solvent from the device while retaining at least a portion of the hydrophilic polymeric material therein.
摘要翻译： 用于处理硅酮水凝胶生物医学装置，特别是诸如隐形眼镜的眼用透镜的方法包括：将硅酮水凝胶生物医学装置与有机溶剂和亲水性聚合物材料的混合物浸渍足够的时间，使该装置为 体积膨胀至少30％; 并从装置中除去有机溶剂，同时将至少一部分亲水性聚合物材料保持在其中。
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9.发明申请Drug delivery systems based on degradible cationic siloxanyl macromonomers 失效基于降解阳离子硅氧烷基大分子单体的药物输送系统公开(公告)号：US20080075780A1
公开(公告)日：2008-03-27
申请号：US11527913
申请日：2006-09-27
申请人： Jay F. Kunzler , Derek Schorzman , Daniel M. Ammon
发明人： Jay F. Kunzler , Derek Schorzman , Daniel M. Ammon
IPC分类号： A61K9/14 , C08F255/00
CPC分类号： A61K9/0051 , A61K47/34
摘要： Matrix controlled diffusion drug delivery systems based on one or more silicon-containing monomers of the general formula: wherein L, X−, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.
摘要翻译： 基于一种或多种以下通式的含硅单体的基质控制扩散药物递送系统：其中L，X-O，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和V 如本文所述。
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公开(公告)号：US06908978B2
公开(公告)日：2005-06-21
申请号：US10000136
申请日：2001-11-02
CPC分类号： C08G77/045 , A61L27/16 , C07F7/0838 , G02B1/043 , C08L51/085 , C08L51/08
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more siloxysilane monomers or the copolymerization of one or more siloxysilane monomers with one or more aromatic or non-aromatic non-siloxy monomers, hydrophobic monomers or hydrophilic monomers.
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