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公开(公告)号：US08637576B2
公开(公告)日：2014-01-28
申请号：US12582535
申请日：2009-10-20
Applicant: Jay P. Powers , Michael R. Degraffenreid , Xiao He , Lisa D. Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
Inventor： Jay P. Powers , Michael R. Degraffenreid , Xiao He , Lisa D. Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC: A61K31/165 , A61K31/44
CPC classification number: C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
Abstract: Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
Abstract translation: 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂化物，立体异构体和前药，以及包含其的药物组合物，并具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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公开(公告)号：US20110082172A1
公开(公告)日：2011-04-07
申请号：US12887416
申请日：2010-09-21
Applicant: Trevor T. Charvat , Hiufung Chu , Antoni Krasinski , Christopher W. Lange , Manmohan Reddy Leleti , Jay P. Powers , Sreenivas Punna , Timothy J. Sullivan , Solomon Ungashe
Inventor： Trevor T. Charvat , Hiufung Chu , Antoni Krasinski , Christopher W. Lange , Manmohan Reddy Leleti , Jay P. Powers , Sreenivas Punna , Timothy J. Sullivan , Solomon Ungashe
IPC: A61K31/454 , C07D207/28 , A61K31/402 , C07D209/52 , A61K31/403 , C07D403/12 , A61K31/4025 , A61K31/4178 , C07D487/04 , C07D403/04 , C07D401/06 , A61P29/00 , A61P25/00 , A61P3/00 , A61P17/00
CPC classification number: C07D207/277 , C07D207/416 , C07D209/46 , C07D209/52 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D413/06 , C07D491/048 , C07D491/052 , C07D493/04
Abstract: Pyrrolidinone carboxamide compounds are provided that are useful for inhibiting the binding of ligands to the ChemR23 receptor.
Abstract translation: 提供吡咯烷酮甲酰胺化合物，其可用于抑制配体与ChemR23受体的结合。
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公开(公告)号：US20100311753A1
公开(公告)日：2010-12-09
申请号：US12823039
申请日：2010-06-24
Applicant: Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
Inventor： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC: A61K31/5377 , C07D211/32 , C07D401/06 , C07D401/12 , C07D413/14 , A61K31/451 , A61K31/4545 , A61K31/454 , A61P9/00 , A61P9/10 , A61P7/02 , A61P25/00 , A61P37/00 , A61P29/00 , A61P3/10 , A61P25/28
CPC classification number: A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US07754890B2
公开(公告)日：2010-07-13
申请号：US12163088
申请日：2008-06-27
Applicant: Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
Inventor： Pingchen Fan , Hiroyuki Goto , Xiao He , Makoto Kakutani , Marc Labelle , Dustin L. McMinn , Jay P. Powers , Yosup Rew , Daqing Sun , Xuelei Yan
IPC: C07D277/26 , A61K31/425
CPC classification number: C07C317/44 , C07C317/14 , C07C317/22 , C07C2601/02 , C07D215/36 , C07D233/54 , C07D277/36 , C07D277/54 , C07D277/56 , C07D295/096 , C07D295/112 , C07D417/04
Abstract: Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
Abstract translation: 描述了式I和II的芳基砜化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US07605289B2
公开(公告)日：2009-10-20
申请号：US11448986
申请日：2006-06-08
Applicant: Jay P. Powers , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
Inventor： Jay P. Powers , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC: C07C233/65 , A61K31/165
CPC classification number: C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
Abstract: Benzamide derivatives of formula I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
Abstract translation: 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂合物，立体异构体和前药，以及包含其的药物组合物，具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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Patent Agency Ranking
公开(公告)号：US20090075975A1
公开(公告)日：2009-03-19
申请号：US12276753
申请日：2008-11-24
Applicant: Michael R. DeGraffenreid , JAY P. POWERS , Daqing Sun , Xuelei Yan
Inventor： Michael R. DeGraffenreid , JAY P. POWERS , Daqing Sun , Xuelei Yan
IPC: A61K31/55 , C07D209/04 , A61K31/404 , C07D403/02 , A61K31/4164 , C07D207/48 , A61K31/40 , C07D213/02 , C07D215/00 , A61P37/00 , A61P29/00 , A61P25/00 , A61P9/00 , A61P3/00 , C12N5/00 , A61K31/33 , C07D225/02 , A61K31/47 , A61K31/4545 , C07D217/22 , C07D295/00 , A61K31/5375 , C07D211/08 , A61K31/445 , C07D223/08
CPC classification number: C07D295/26 , C07D207/48 , C07D209/08 , C07D211/96 , C07D215/58 , C07D217/08 , C07D401/04 , C07D401/06 , C07D403/04
Abstract: Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
Abstract translation: 描述了式I的芳基磺酰胺化合物，并具有治疗效用，特别是在治疗糖尿病，肥胖症和相关病症和病症中：
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公开(公告)号：US07132438B2
公开(公告)日：2006-11-07
申请号：US10268412
申请日：2002-10-09
Applicant: Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
Inventor： Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
IPC: A61K31/4184 , C07D235/30
CPC classification number: C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.
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公开(公告)号：US08772296B2
公开(公告)日：2014-07-08
申请号：US11806461
申请日：2007-05-31
Applicant: Jay P. Powers , Michael Degraffenreid , Lisa Julian , Jacob Kaizerman , Dustin McMinn , Yosup Rew , Daqing Sun , Xuelei Yan , Zhulun Wang , Felix Gonzalez Lopez De Turiso
Inventor： Jay P. Powers , Michael Degraffenreid , Lisa Julian , Jacob Kaizerman , Dustin McMinn , Yosup Rew , Daqing Sun , Xuelei Yan , Zhulun Wang , Felix Gonzalez Lopez De Turiso
IPC: A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , A61P3/04 , A61P3/10 , C07C235/42 , C07C271/12 , C07D213/56 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/30 , C07D333/24 , C07D333/38 , C07D277/22 , C07C237/24 , C07C237/42 , C07C237/22 , C07C255/31 , C07C255/46 , C07C271/20 , C07C307/06 , C07D213/30 , C07D213/53
CPC classification number: C07C235/42 , A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C237/22 , C07C237/24 , C07C237/42 , C07C255/31 , C07C255/46 , C07C255/60 , C07C271/12 , C07C271/20 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07C2603/94 , C07D213/30 , C07D213/53 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/22 , C07D277/24
Abstract: Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.
Abstract translation: 描述了式I的苯甲酰胺衍生物，并且具有治疗用途，特别是在治疗糖尿病，肥胖症和相关病症和病症中：其中R1，R2，R3，R4，R5，R6，R7，R8和n如本文所定义。
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公开(公告)号：US08076376B2
公开(公告)日：2011-12-13
申请号：US11490143
申请日：2006-07-21
Applicant: Jay P. Powers , Xiao He , Dustin McMinn , Yosup Rew , Daqing Sun
Inventor： Jay P. Powers , Xiao He , Dustin McMinn , Yosup Rew , Daqing Sun
IPC: A61K31/18 , C07C311/37
CPC classification number: C07C311/21 , C07C311/44 , C07C2601/02 , C07C2601/04
Abstract: Aniline sulfonamide derivatives according to formula I have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R1, R2, R3, R4, R5, R6, and L are set forth in the description.
Abstract translation: 根据式I的苯胺磺酰胺衍生物具有治疗效用，特别是治疗糖尿病，肥胖症和相关病症和疾病：其中R1，R2，R3，R4，R5，R6和L在说明书中阐述。
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公开(公告)号：US20100069447A1
公开(公告)日：2010-03-18
申请号：US12582535
申请日：2009-10-20
Applicant: Jay P. POWERS , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
Inventor： Jay P. POWERS , Michael Degraffenreid , Xiao He , Lisa Julian , Dustin L. McMinn , Daqing Sun , Yosup Rew , Xuelei Yan
IPC: A61K31/44 , C07C233/00 , C07D213/02 , A61K31/166 , A61P37/06
CPC classification number: C07D277/28 , C07C235/42 , C07C235/54 , C07C237/42 , C07C255/29 , C07C255/31 , C07C255/44 , C07C255/46 , C07C255/60 , C07C317/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/52 , C07D211/60 , C07D211/64 , C07D213/40 , C07D213/61 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D233/64 , C07D295/192 , C07D307/22 , C07D309/14 , C07D333/20
Abstract: Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.
Abstract translation: 描述了式I和II的苯甲酰胺衍生物及其药学上可接受的盐，溶剂化物，立体异构体和前药，以及包含其的药物组合物，并具有治疗用途，特别是治疗糖尿病，肥胖症和相关病症和病症： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所提供。
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