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    Particle immunoassay using a compact matrix
    1.
    发明授权
    Particle immunoassay using a compact matrix 失效
    使用紧凑型基质进行粒子免疫测定

    公开(公告)号：US5869347A

    公开(公告)日：1999-02-09

    申请号：US822158

    申请日：1997-03-17

    申请人： Dieter Josef ,  Suzanne Greber ,  Jean Adam

    发明人： Dieter Josef ,  Suzanne Greber ,  Jean Adam

    IPC分类号： B01L3/14 ,  G01N33/543 ,  G01N33/547 ,  G01N33/53 ,  G01N33/536

    CPC分类号： B01L3/5021 ,  G01N33/54313

    摘要： This invention relates to a method of detecting an analyte in a test liquid by means of agglutination, with the test liquid being brought into contact with an agglutinin and a reaction between the analyte and the agglutinin determined. In addition, reaction vessels and reagents for implementing the method of the invention are disclosed.

    摘要翻译： 本发明涉及通过凝集检测试验液体中的分析物的方法，使测试液与凝集素接触，并测定分析物与凝集素之间的反应。 此外，公开了用于实施本发明的方法的反应容器和试剂。

    Method and card for detecting antigens and/or antibodies
    5.
    发明授权
    Method and card for detecting antigens and/or antibodies 失效
    用于检测抗原和/或抗体的方法和卡

    公开(公告)号：US5338689A

    公开(公告)日：1994-08-16

    申请号：US969532

    申请日：1992-10-30

    申请人： Lapierre Yves ,  Dieter Josef ,  Jean Adam ,  Susanne Greber-Widmer

    发明人： Lapierre Yves ,  Dieter Josef ,  Jean Adam ,  Susanne Greber-Widmer

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/555 ,  G01N33/80 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N33/537 ,  G01N33/538 ,  G01N33/558

    CPC分类号： G01N33/80 ,  G01N33/5304 ,  G01N33/54313 ,  G01N33/555 ,  G01N2035/00366 ,  G01N2035/00495 ,  G01N35/026 ,  G01N35/1079 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/824

    摘要： A method of detecting target antibodies or antigens by reaction with specific binding partners thereto is disclosed. One of the target or the binding partner is bound to a carrier, and the other is unbound. The complex between the target and the binding partner, with one being carrier-bound, forms an optically detectable binding complex. A microreaction vessel having an upper portion, a transition portion and a lower portion is utilized, wherein the upper portion has a greater diameter or width than the lower portion, and the transition portion is situated between the upper portion and the lower portion, and is funnel shaped. The microreaction vessel contains a slurry or suspension of inert particles, and unbound target or binding partner thereto. A solution of the carrier bound target or binding partner thereto is added to the vessel, which is then centrifuged to produce an optical determination of the target. A strongly positive reaction is indicated by a complex lying upon or in a top portion of a layer inert particles, a weakly positive reaction is indicated by a complex located within a lower portion of the layer of inert particles, and a negative reaction is indicated by the absence of a complex, with the carrier bound material lying beneath the inert particles.

    摘要翻译： 公开了通过与特异性结合配偶体反应来检测靶抗体或抗原的方法。 目标或绑定合作伙伴之一与承运人绑定，另一方未绑定。 靶和结合配偶体之间的复合物，其中一个与载体结合，形成光学上可检测的结合复合物。 使用具有上部，过渡部分和下部的微反应器，其中上部具有比下部更大的直径或宽度，并且过渡部分位于上部和下部之间，并且是 漏斗形。 微反应容器含有惰性颗粒的浆液或悬浮液，以及未结合的靶标或结合配对物。 将载体结合的靶或结合配对物的溶液加入到容器中，然后将其离心以产生靶的光学测定。 强阳性反应由位于层惰性颗粒的顶部或顶部的复合物表示，弱阳性反应由位于惰性颗粒层的下部的络合物表示，负反应由 没有复合物，载体结合的材料位于惰性颗粒之下。