Compositions for reductive aminations utilizing supported tricarboxyborohydride reagents and methods of using the same
    8.
    发明授权
    Compositions for reductive aminations utilizing supported tricarboxyborohydride reagents and methods of using the same 有权
    使用负载型三羧酸硼氢化物试剂的还原性胺化剂组合物及其使用方法

    公开(公告)号:US07985882B1

    公开(公告)日:2011-07-26

    申请号:US10226637

    申请日:2002-08-23

    IPC分类号: C07C209/24

    摘要: A modified solid-support for use as a supported reagent for use in reduction reactions, including reductive amination comprising a solid-support having an tetrasubstituted ammonium cation species ionically bonded to a borohydride anion species extending therefrom having the general formula: wherein P is a solid-support, S is a spacer group selected from the group consisting of alkylene, {including —(CH2)n—}, alkyleneoxy {including -0(CH2)n—}, alkylenethio {including —S(CH2)n—} and alkylenecarboxy, {including —O(O)C—(CH2)n—}, n=2-16. R1, R2, R3 and R are each independently selected from the group consisting of alkyl, cycloalkyl, haloalkyl and aryl. Y equals 1, 2 or 3. H is hydrogen or deuterium.

    摘要翻译: 一种用作还原反应中用作负载型试剂的改性固体支持物,包括还原性胺化,其包括具有与其延伸的硼氢化物阴离子物质离子键合的四取代铵阳离子物质的固体支持物,其中P是固体 - 支持,S是选自亚烷基(包括 - (CH 2)n - ),亚烷基氧基(包括-O(CH 2)n - ),亚烷基硫(包括-S(CH 2)n - )和 亚烷基羧基(包括-O(O)C(CH 2)n - ),n = 2-16。 R1,R2,R3和R各自独立地选自烷基,环烷基,卤代烷基和芳基。 Y等于1,2或3.H是氢或氘。