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11 条记录 (耗时 0.024 秒)

    Local delivery of fibrinolysis enhancing agents
    1.
    发明授权
    Local delivery of fibrinolysis enhancing agents 失效
    局部递送纤维蛋白溶解增强剂

    公开(公告)号：US06461640B1

    公开(公告)日：2002-10-08

    申请号：US08967619

    申请日：1997-11-12

    申请人： Jeffrey A. Hubbell ,  Jennifer L. Hill-West ,  Randall C. Dunn

    发明人： Jeffrey A. Hubbell ,  Jennifer L. Hill-West ,  Randall C. Dunn

    IPC分类号： A61K910

    CPC分类号： A61L31/16 ,  A61K38/58 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/42 ,  A61L2300/604 ,  Y10S514/822 ,  Y10S514/944

    摘要： A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolytic agent, preferably urokinase, tPA, hirudin, or most preferably, ancrod. In the most preferred embodiment, the matrix is extremely thin and is polymerized in situ to form a biodegradable polymeric matrix. The matrix provides controlled release of the agent over a period of time effective to prevent surgical adhesions and is biodegradable, usually within the same time frame. Examples demonstrate that the combination of the matrix and the urokinase, tPA, hirudin, or ancrod is effective in preventing surgical adhesions.

    摘要翻译： 描述了通过局部施用纤维蛋白溶解增强剂来预防粘连的方法。 该方法使用局部施用的聚合物基质用于递送纤维蛋白溶解剂，优选尿激酶，tPA，水蛭素，或最优选地辅助。 在最优选的实施方案中，基质非常薄并且在原位聚合以形成可生物降解的聚合物基质。 该基质提供了有效预防手术粘连的一段时间内的药剂的控制释放，并且通常在相同的时间内可生物降解。 实施例证明，基质和尿激酶，tPA，水蛭素或辅酶的组合在预防手术粘连方面是有效的。

    Multifunctional organic polymers
    5.
    发明授权
    Multifunctional organic polymers 失效
    多功能有机聚合物

    公开(公告)号：US5627233A

    公开(公告)日：1997-05-06

    申请号：US465949

    申请日：1995-06-06

    申请人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    发明人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    IPC分类号： A61L27/00 ,  A61K9/50 ,  A61K47/48 ,  A61L31/06 ,  A61L33/00 ,  C08G63/91 ,  C08G73/00 ,  C08G81/00 ,  C08G81/02 ,  C08L77/00 ,  C08L79/00 ,  C08L101/00 ,  C09D187/00 ,  C08L1/00 ,  C08G69/48

    CPC分类号： C08G81/00 ,  A61K47/48238 ,  A61K47/48315 ,  A61K9/5031 ,  A61K9/5073 ,  A61L31/06

    摘要： Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

    摘要翻译： 本文描述的是用于抑制细胞和细胞，细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。 聚合物材料的一个组分很好地吸附到细胞或组织上，而聚合物材料的其它组分不能很好地吸附到组织上。 使用不带电荷的水溶性聚合物（多项式）作为非结合成分，使用在生理pH（聚阳离子）下带正电的水溶性聚合物作为组织结合成分。 当双官能聚合物材料接触组织时，组织结合组分结合并因此固定所连接的非结合组分，其然后将一般远离组织表面延伸，并空间阻断其它组织的附着。 该方法和组合物可用于抑制手术后粘连的形成，保护受损的血管免受血栓形成和再狭窄，并降低附着依赖性肿瘤细胞的转移程度。

    Methods for modifying cell contact with a surface
    6.
    发明授权
    Methods for modifying cell contact with a surface 失效
    修改细胞与表面接触的方法

    公开(公告)号：US5567440A

    公开(公告)日：1996-10-22

    申请号：US471390

    申请日：1995-06-06

    申请人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumbeller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    发明人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumbeller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    IPC分类号： A61L27/00 ,  A61K9/50 ,  A61K47/48 ,  A61L31/06 ,  A61L33/00 ,  C08G63/91 ,  C08G73/00 ,  C08G81/00 ,  C08G81/02 ,  C08L77/00 ,  C08L79/00 ,  C08L101/00 ,  C09D187/00 ,  A61K9/14

    CPC分类号： C08G81/00 ,  A61K47/48238 ,  A61K47/48315 ,  A61K9/5031 ,  A61K9/5073 ,  A61L31/06

    摘要： Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

    摘要翻译： 本文描述的是用于抑制细胞和细胞，细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。 聚合物材料的一个组分很好地吸附到细胞或组织上，而聚合物材料的其它组分不能很好地吸附到组织上。 使用不带电荷的水溶性聚合物（多项式）作为非结合成分，使用在生理pH（聚阳离子）下带正电的水溶性聚合物作为组织结合成分。 当双官能聚合物材料接触组织时，组织结合组分结合并因此固定所连接的非结合组分，其然后将一般远离组织表面延伸，并空间阻断其它组织的附着。 该方法和组合物可用于抑制手术后粘连的形成，保护受损的血管免受血栓形成和再狭窄，并降低附着依赖性肿瘤细胞的转移程度。

    Multifunctional organic polymers
    9.
    发明授权
    Multifunctional organic polymers 失效
    多功能有机聚合物

    公开(公告)号：US5462990A

    公开(公告)日：1995-10-31

    申请号：US132507

    申请日：1993-10-05

    申请人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    发明人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    IPC分类号： A61L27/00 ,  A61K9/50 ,  A61K47/48 ,  A61L31/06 ,  A61L33/00 ,  C08G63/91 ,  C08G73/00 ,  C08G81/00 ,  C08G81/02 ,  C08L77/00 ,  C08L79/00 ,  C08L101/00 ,  C09D187/00 ,  C08L1/00

    CPC分类号： C08G81/00 ,  A61K47/48238 ,  A61K47/48315 ,  A61K9/5031 ,  A61K9/5073 ,  A61L31/06

    摘要： Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

    摘要翻译： 本文描述的是用于抑制细胞和细胞，细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。 聚合物材料的一个组分很好地吸附到细胞或组织上，而聚合物材料的其它组分不能很好地吸附到组织上。 使用不带电荷的水溶性聚合物（多项式）作为非结合成分，使用在生理pH（聚阳离子）下带正电的水溶性聚合物作为组织结合成分。 当双官能聚合物材料接触组织时，组织结合组分结合并因此固定所连接的非结合组分，其然后将一般远离组织表面延伸，并空间阻断其它组织的附着。 该方法和组合物可用于抑制手术后粘连的形成，保护受损的血管免受血栓形成和再狭窄，并降低附着依赖性肿瘤细胞的转移程度。