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公开(公告)号:US20050228042A1
公开(公告)日:2005-10-13
申请号:US10497777
申请日:2002-12-03
申请人: Jens Frisvad , Lene Lange , Kirk Schnorr , Steen Stender , Steen Stender , Thomas Larsen
发明人: Jens Frisvad , Lene Lange , Kirk Schnorr , Steen Stender , Steen Stender , Thomas Larsen
IPC分类号: C12N9/99 , A61K31/192 , A61K31/22 , A61K31/366 , A61K31/616 , A61P3/06 , A61P19/10 , A61P37/06 , A61P43/00 , C07D309/30 , C12P7/42 , C12P7/62 , C12P17/06 , C12R1/80 , A61K31/225
CPC分类号: C07D309/30
摘要: The present invention relates to compounds with structures resembling natural statins isolated from Penicillium sp. (Formula I); where R1 represents OH, C6H5COO, R6COO and R6 represents C1-C5 alkyl; R2-4 represents H, C1-C5 alkyl C1-C5 acyl, R5 represents H, CH3; and X represents a compound of (Formula II) or (Formula III).
摘要翻译: 本发明涉及具有类似于从青霉属分离的天然他汀类的结构的化合物。 (式I); 其中R 1代表OH,C 6 H 5 COO,R 6 COO和R 6, / SUB表示C 1 -C 5烷基; R 2-4表示H,C 1 -C 5烷基C 1 -C 5 - 酰基,R 5表示H,CH 3, X表示式(II)或(式III)的化合物。