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1.发明申请Delivery System For Bioactive Agents on the Basis of a Polymeric Drug Carrier Comprising an Amphiphilic Block Polymer and a Polylacticacid Derivative 审中-公开基于包含两亲性嵌段聚合物和聚乳酸衍生物的聚合物药物载体的生物活性剂的递送系统公开(公告)号：US20080260850A1
公开(公告)日：2008-10-23
申请号：US11568313
申请日：2005-05-06
申请人： Yil-Woong Yi , Sa-Won Lee , Jeong-Il Yu , Dong-Hoon Chang , Min-Hyo Seo , Hye-Won Kang , Jae-Hong Kim
发明人： Yil-Woong Yi , Sa-Won Lee , Jeong-Il Yu , Dong-Hoon Chang , Min-Hyo Seo , Hye-Won Kang , Jae-Hong Kim
CPC分类号： C08G63/912 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K9/5153 , A61K47/34 , C08G2261/126 , C08L53/00 , C08L67/00 , C08L67/04 , C08L87/005 , C08L101/06 , C08L2666/02
摘要： Delivery system for bioactive agents on the basis of a polymeric drug carrier formed from compositions comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block having a terminal hydroxyl group substituted with a tocopherol or cholesterol group, and a polylactic acide derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or trivalent metal ion, which is obtained by adding the di- or trivalent metal ion to the polymeric composition.
摘要翻译： 基于由包含亲水嵌段的两亲性嵌段共聚物和具有被生育酚或胆固醇基取代的末端羟基的疏水嵌段的组合物形成的聚合物药物载体的递送系统和聚乳酸酰胺衍生物，其中一端 的聚乳酸与至少一个羧基共价结合。 聚乳酸衍生物的羧基可以通过将二价或三价金属离子加入到聚合物组合物中而获得的二价或三价金属离子固定。
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2.发明申请Amphiphilic block copolymer and polymeric compostition comprising the same for drug delivery 有权两亲嵌段共聚物和聚合物组合物，其包含与药物递送相同的组合物公开(公告)号：US20080152616A1
公开(公告)日：2008-06-26
申请号：US11974196
申请日：2007-10-10
申请人： Min Hyo Seo , Sa-Won Lee , Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Hye-Jeong Yoon , Jeong-Kyung Kim
发明人： Min Hyo Seo , Sa-Won Lee , Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Hye-Jeong Yoon , Jeong-Kyung Kim
IPC分类号： A61K31/785 , A61P35/00
CPC分类号： A61K9/1075 , C08G63/08 , C08L53/00 , C08L2666/14 , C08L2666/02
摘要： The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.
摘要翻译： 本发明涉及亲水嵌段和具有末端羟基的疏水嵌段的两亲嵌段共聚物，其中疏水基团的末端羟基被生育酚或胆固醇基团取代。 它还涉及能够在水溶液中形成稳定的胶束的聚合物组合物，其包含两亲嵌段共聚物和聚乳酸衍生物，其中聚乳酸的一个或多个末端与至少一个羧基共价结合。
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3.发明申请Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery 有权两亲性嵌段共聚物和包含其用于药物递送的聚合物组合物公开(公告)号：US20050201972A1
公开(公告)日：2005-09-15
申请号：US10962204
申请日：2004-10-07
申请人： Min Seo , Bong Kim , In Choi , Myung Shim , Sa-Won Lee , Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Hye-Jeong Yoon , Jeong-Kyung Kim
发明人： Min Seo , Bong Kim , In Choi , Myung Shim , Sa-Won Lee , Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Hye-Jeong Yoon , Jeong-Kyung Kim
IPC分类号： A61K31/785 , C08L39/04
CPC分类号： A61K9/1075 , C08G63/08 , C08L53/00 , C08L2666/14 , C08L2666/02
摘要： The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.
摘要翻译： 本发明涉及亲水嵌段和具有末端羟基的疏水嵌段的两亲嵌段共聚物，其中疏水基团的末端羟基被生育酚或胆固醇基团取代。 它还涉及能够在水溶液中形成稳定的胶束的聚合物组合物，其包含两亲嵌段共聚物和聚乳酸衍生物，其中聚乳酸的一个或多个末端与至少一个羧基共价结合。
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4.发明授权Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery 有权两亲性嵌段共聚物和包含其用于药物递送的聚合物组合物公开(公告)号：US08349306B2
公开(公告)日：2013-01-08
申请号：US11974196
申请日：2007-10-10
申请人： Min Hyo Seo , Sa-Won Lee , Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Hye-Jeong Yoon , Jeong-Kyung Kim
发明人： Min Hyo Seo , Sa-Won Lee , Myung-Han Hyun , Jeong-Il Yu , Dong-Hoon Chang , Hye-Jeong Yoon , Jeong-Kyung Kim
IPC分类号： A61K31/74
CPC分类号： A61K9/1075 , C08G63/08 , C08L53/00 , C08L2666/14 , C08L2666/02
摘要： The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.
摘要翻译： 本发明涉及亲水嵌段和具有末端羟基的疏水嵌段的两亲嵌段共聚物，其中疏水基团的末端羟基被生育酚或胆固醇基团取代。 它还涉及能够在水溶液中形成稳定的胶束的聚合物组合物，其包含两亲嵌段共聚物和聚乳酸衍生物，其中聚乳酸的一个或多个末端与至少一个羧基共价结合。
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5.发明授权Polymeric micelle compositions with improved stability and methods of making thereof 有权具有改进的稳定性的聚合胶束组合物及其制备方法公开(公告)号：US07879317B2
公开(公告)日：2011-02-01
申请号：US10493043
申请日：2002-10-17
申请人： Min-Hyo Seo , Sa-Won Lee , Hee-Jo Kim , Jeong-Kyung Kim , Myung-Han Huyn , Jeong-il Yu , Bong-Oh Kim
发明人： Min-Hyo Seo , Sa-Won Lee , Hee-Jo Kim , Jeong-Kyung Kim , Myung-Han Huyn , Jeong-il Yu , Bong-Oh Kim
CPC分类号： A61K9/1075 , C08L53/00 , C08L53/005 , C08L2666/02 , C08L2666/14
摘要： Polymeric compositions capable of forming stable micelles in an aqueous solution, comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or tri-valent metal ion, obtained by adding the di- or tri-valent metal ion to the polymeric composition.
摘要翻译： 能够在包含亲水嵌段和疏水嵌段的两亲性嵌段共聚物的水溶液中形成稳定的胶束的聚合物组合物和聚乳酸的一端与至少一个羧基共价结合的聚乳酸衍生物。 聚乳酸衍生物的羧基可以通过将二价或三价金属离子加入到聚合物组合物中而获得的二价或三价金属离子固定。
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