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公开(公告)号:US20110275608A1
公开(公告)日:2011-11-10
申请号:US13143998
申请日:2010-01-07
申请人: Martha E. Rodriguez , David A. Mareska , Jeremy J. Hans , Darren M. Harvey , Robert D. Groneberg , Michael O'Sullivan
发明人: Martha E. Rodriguez , David A. Mareska , Jeremy J. Hans , Darren M. Harvey , Robert D. Groneberg , Michael O'Sullivan
IPC分类号: A61K31/454 , C07D417/14 , C07D413/14 , C07D409/06 , C07D417/06 , C07D401/06 , A61K31/4535 , C07D409/14 , A61K31/4725 , C07D471/04 , A61K31/437 , C07D498/04 , A61K31/5025 , A61K31/506 , A61K31/496 , A61K31/5377 , A61P3/10 , C07D413/06
CPC分类号: C07D413/14 , A61K31/445 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/14 , C07D471/04
摘要: A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.
摘要翻译: 一种预防和/或治疗代谢性疾病,脑血管疾病等的方法,其包括向哺乳动物施用有效量的式(I)化合物:其中所有符号具有与说明书中定义的相同的含义; 其盐,其N-氧化物,其溶剂合物或其前药。 和式(I-1)的新化合物:其中所有符号具有与说明书中定义的相同的含义; 其盐,其N-氧化物,其溶剂化物或其前药具有抗糖尿病作用和神经保护作用。 因此,式(I)的化合物和式(I-1)的化合物可用于预防和/或治疗诸如糖尿病,脑血管疾病如中风等的代谢疾病的方法。
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公开(公告)号:US08809538B2
公开(公告)日:2014-08-19
申请号:US13143998
申请日:2010-01-07
申请人: Martha E. Rodriguez , David A. Mareska , Jeremy J. Hans , Darren M. Harvey , Robert D. Groneberg , Michael O'Sullivan
发明人: Martha E. Rodriguez , David A. Mareska , Jeremy J. Hans , Darren M. Harvey , Robert D. Groneberg , Michael O'Sullivan
IPC分类号: C07D403/00 , C07D403/14 , A61K31/454 , A61K31/4545
CPC分类号: C07D413/14 , A61K31/445 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/14 , C07D471/04
摘要: A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.
摘要翻译: 一种预防和/或治疗代谢性疾病,脑血管疾病等的方法,其包括向哺乳动物施用有效量的式(I)化合物:其中所有符号具有与说明书中定义的相同的含义; 其盐,其N-氧化物,其溶剂合物或其前药。 和式(I-1)的新化合物:其中所有符号具有与说明书中定义的相同的含义; 其盐,其N-氧化物,其溶剂化物或其前药具有抗糖尿病作用和神经保护作用。 因此,式(I)的化合物和式(I-1)的化合物可用于预防和/或治疗诸如糖尿病,脑血管疾病如中风等的代谢疾病的方法。
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