公开(公告)号：US20110300102A1

公开(公告)日：2011-12-08

申请号：US13202309

申请日：2010-02-23

申请人： Hyung Min Chung ,  Ji Mi Kim ,  Min Ji Lee ,  Ki Sung Hong ,  Jong Hyuk Sung

发明人： Hyung Min Chung ,  Ji Mi Kim ,  Min Ji Lee ,  Ki Sung Hong ,  Jong Hyuk Sung

IPC分类号： A61K38/20 ,  A61K8/64 ,  A61P17/02 ,  A61Q19/08 ,  A61K38/18 ,  A61P17/00

CPC分类号： A61Q19/08 ,  A61K8/982

摘要： The present invention relates to a composition for skin regeneration, using a culture medium or a secretion in the culture of an embryonic stem cell-derived endothelial progenitor cell, and to the use thereof. As the present invention uses the secretion in the culture as a medicine and not the embryonic stem cell-derived endothelial progenitor cell itself, the risk of teratoma formation is prevented, and angiogenic activity is promoted to achieve improved effectiveness in healing wounds and burn wounds. The composition of the present invention, when used as a material in cosmetics, increases collagen synthesis and thus prevents skin aging. Particularly, the composition of the present invention in which the secretion in the culture is concentrated into a high concentration provides superior wound-healing effects as compared to a conventional human growth hormone (hGH).

摘要翻译： 本发明涉及使用胚胎干细胞来源的内皮祖细胞的培养物中的培养基或分泌物进行皮肤再生的组合物及其用途。 由于本发明使用培养物中的分泌作为药物而不是胚胎干细胞衍生的内皮祖细胞本身，因此可以预防畸胎瘤形成的风险，促进血管生成活性，以达到愈合伤口和烧伤伤口的有效性。 当用作化妆品中的材料时，本发明的组合物增加胶原合成，从而防止皮肤老化。 特别地，与常规的人生长激素（hGH）相比，培养物中的分泌物浓缩成高浓度的本发明的组合物提供了优异的伤口愈合效果。