公开(公告)号：US11407752B2

公开(公告)日：2022-08-09

申请号：US16938886

申请日：2020-07-24

申请人： Jia Zhou ,  Pei-Yong Shi ,  Jimin Xu ,  Xuping Xie

发明人： Jia Zhou ,  Pei-Yong Shi ,  Jimin Xu ,  Xuping Xie

IPC分类号： C07D471/20 ,  C07D495/04 ,  A61P31/14

摘要： A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3′-indoline]-2′,5(3H)-dione analogues, the use thereof and the preparation thereof.

公开(公告)号：US11117865B2

公开(公告)日：2021-09-14

申请号：US16442526

申请日：2019-06-16

申请人： Jia Zhou ,  Allan R. Brasier ,  Bing Tian ,  Zhiqing Liu ,  Haiying Chen ,  Erik Rytting

发明人： Jia Zhou ,  Allan R. Brasier ,  Bing Tian ,  Zhiqing Liu ,  Haiying Chen ,  Erik Rytting

IPC分类号： A61K9/14 ,  A61P29/00 ,  C07D311/00 ,  C07D215/38 ,  C07D207/48 ,  C07D241/04 ,  C07D311/30 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04

摘要： Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.

公开(公告)号：US20190292168A1

公开(公告)日：2019-09-26

申请号：US16441748

申请日：2019-06-14

申请人： Haitao Hu ,  Jia Zhou ,  Zhiqing Liu

发明人： Haitao Hu ,  Jia Zhou ,  Zhiqing Liu

IPC分类号： C07D403/06 ,  C07D401/06 ,  C07D207/48 ,  A61P31/18

摘要： The invention relates generally to novel small molecule BRD4 modulators for HIV, the preparation thereof as well as the use thereof.

公开(公告)号：US10161223B2

公开(公告)日：2018-12-25

申请号：US15084598

申请日：2016-03-30

申请人： Jia Zhou ,  Harold Dean Brannon ,  Paul S. Carman ,  Leiming Li ,  Thomas Ray Starks ,  D. V. Satyanarayana Gupta ,  Harold G. Hudson ,  Scott G. Nelson

发明人： Jia Zhou ,  Harold Dean Brannon ,  Paul S. Carman ,  Leiming Li ,  Thomas Ray Starks ,  D. V. Satyanarayana Gupta ,  Harold G. Hudson ,  Scott G. Nelson

IPC分类号： E21B37/06 ,  C09K8/52 ,  E21B33/134 ,  C09K8/62 ,  C09K8/70 ,  C09K8/80 ,  E21B43/26 ,  E21B43/267 ,  C09K8/76 ,  E21B33/138 ,  C09K8/575 ,  C09K8/68 ,  E21B43/04 ,  C09K8/035 ,  C09K8/12 ,  C09K8/34 ,  E21B21/00

摘要： A method of hydraulically fracturing a subterranean formation penetrated by a wellbore comprises: providing a diverting fluid comprising a carrier fluid, a first superabsorbent polymer and a second superabsorbent polymer, the second superabsorbent polymer having a shape, or a composition, or a combination thereof different from that of the first superabsorbent polymer; injecting the diverting fluid into the subterranean formation; and injecting a fracturing fluid into the formation after injecting the diverting fluid. A viscosity modifying agent can be present in the diverting fluid. Superabsorbent polymers can also be used to develop a temporary filter cake at the formation face to reduce or eliminate the fluid leakoff out of the wellbore.

公开(公告)号：US10113396B2

公开(公告)日：2018-10-30

申请号：US15084833

申请日：2016-03-30

申请人： Scott Gregory Nelson ,  Hong Sun ,  Jia Zhou ,  Leiming Li ,  Xiaolan Wang ,  Qi Qu

发明人： Scott Gregory Nelson ,  Hong Sun ,  Jia Zhou ,  Leiming Li ,  Xiaolan Wang ,  Qi Qu

IPC分类号： E21B43/267 ,  E21B37/06 ,  C09K8/52 ,  E21B33/134 ,  C09K8/62 ,  C09K8/70 ,  C09K8/80 ,  E21B43/26 ,  C09K8/76 ,  E21B33/138 ,  C09K8/575 ,  C09K8/68 ,  E21B43/04 ,  C09K8/035 ,  C09K8/12 ,  C09K8/34 ,  E21B21/00

摘要： A method of fracturing a subterranean formation penetrated by a well comprises: forming a fracturing composition comprising a carrier fluid; and a superabsorbent polymer component comprising one or more of the following: a first composite of a proppant and a first superabsorbent polymer in an unhydrated form, the first superabsorbent polymer being at least partially embedded in a void area of the proppant; a coated superabsorbent polymer; a superabsorbent material having a three-dimensional network; or a second composite of a second superabsorbent polymer and a slow-release breaker; and pumping the hydraulic fracturing composition into the subterranean formation to create or enlarge a fracture.

公开(公告)号：US09828844B2

公开(公告)日：2017-11-28

申请号：US14169698

申请日：2014-01-31

申请人： Jia Zhou ,  Qi Qu ,  Scott G. Nelson ,  Hong Sun ,  Leiming Li

发明人： Jia Zhou ,  Qi Qu ,  Scott G. Nelson ,  Hong Sun ,  Leiming Li

IPC分类号： E21B43/267 ,  C09K8/68

CPC分类号： E21B43/267 ,  C09K8/685 ,  C09K2208/26

摘要： A hydraulic fracturing composition includes: a superabsorbent polymer in an expanded state; a plurality of proppant particles disposed in the superabsorbent polymer; an additive comprising a surfactant, a viscose polymer, or a combination thereof, and a fluid to expand the superabsorbent polymer into the expanded state. A process for disposing a plurality of proppant particles in a fracture comprises: disposing a hydraulic fracturing composition in a downhole environment; forming a fracture; disposing the hydraulic fracturing composition in the fracture; breaking the superabsorbent polymer after forming the fracture; and releasing the plurality of proppant particles from superabsorbent polymer. The process also comprises injecting a proppant-free fluid and a proppant-containing fluid in an alternating order into a subterranean formation.

公开(公告)号：US20170239346A1

公开(公告)日：2017-08-24

申请号：US15441474

申请日：2017-02-24

申请人： Jia Zhou ,  Jai S. Rudra ,  Kathryn A. Cunningham

发明人： Jia Zhou ,  Jai S. Rudra ,  Kathryn A. Cunningham

IPC分类号： A61K39/385 ,  A61K39/00

CPC分类号： A61K39/385 ,  A61K39/0013 ,  A61K2039/6012 ,  A61K2039/6031 ,  A61K2039/627

摘要： Certain embodiments are directed to chemically defined self-adjuvanting cocaine vaccines composed of novel cocaine haptens and self-assembling peptide domains.

公开(公告)号：US20160347985A1

公开(公告)日：2016-12-01

申请号：US15153870

申请日：2016-05-13

申请人： Leiming Li ,  Jia Zhou ,  Hong Sun ,  Harold D. Brannon ,  Magnus Legemah

发明人： Leiming Li ,  Jia Zhou ,  Hong Sun ,  Harold D. Brannon ,  Magnus Legemah

IPC分类号： C09K8/512 ,  E21B43/26 ,  E21B33/138 ,  C09K8/502

CPC分类号： E21B43/267 ,  C09K8/508 ,  C09K8/605 ,  C09K8/80 ,  C09K2208/08 ,  C09K2208/20 ,  C09K2208/24 ,  C09K2208/26

摘要： A fluid for temporarily plugging a hydrocarbon-bearing formation is disclosed. The fluid includes a carrier fluid and a crosslinked synthetic polymer, wherein the polymer comprises a labile group to degrade the polymer when exposed to a change in a condition of the fluid.

摘要翻译： 公开了一种用于暂时堵塞含烃地层的流体。 流体包括载体流体和交联的合成聚合物，其中当暴露于流体状态的变化时，聚合物包含不稳定基团以降解聚合物。

公开(公告)号：US20160095831A1

公开(公告)日：2016-04-07

申请号：US14967649

申请日：2015-12-14

申请人： Mark HELLMICH ,  Jia ZHOU ,  Csaba SZABO

发明人： Mark HELLMICH ,  Jia ZHOU ,  Csaba SZABO

IPC分类号： A61K31/195 ,  C07C291/04 ,  A61K31/27 ,  A61K45/06 ,  A61K31/7105 ,  A61K31/221

CPC分类号： A61K31/195 ,  A61K31/22 ,  A61K31/221 ,  A61K31/222 ,  A61K31/27 ,  A61K31/325 ,  A61K31/7105 ,  A61K45/06 ,  C07C291/04 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y402/01022

摘要： In certain aspects the methods comprise administering an inhibitor of hydrogen sulfide biosynthesis, a cystathionine-β-synthase (CBS) inhibitor, or a hydrogen sulfide neutralizing agent to a patient having a cancer associated with elevated production of hydrogen sulfide.

摘要翻译： 在某些方面，所述方法包括向具有与硫化氢生产提高相关的癌症的患者施用硫化氢生物合成抑制剂，胱硫醚 - 硫酸钠（CBS）抑制剂或硫化氢中和剂。

公开(公告)号：US09134821B2

公开(公告)日：2015-09-15

申请号：US13981083

申请日：2012-01-18

申请人： Xueping Zou ,  Jia Zhou ,  Guoying Du

发明人： Xueping Zou ,  Jia Zhou ,  Guoying Du

IPC分类号： G06F3/0354 ,  G06T11/20 ,  G06F3/0488

CPC分类号： G06F3/03545 ,  G06F3/04883 ,  G06T11/203

摘要： Provided are a method and device for implementing the original calligraphy of handwriting. The method comprises: carrying out a real time sampling of a contact to obtain position information about the sampling point and the pen width at the sampling point; determining a central line of the stroke determined by adjacent sampling points; determining position information about a key point of the corresponding stroke according to the central line and the pen width at the sampling point; dividing the key point of the stroke into groups to determine the type thereof; generating a calligraphy outline of the corresponding stroke by drawing an arc and/or a line according to the type of the key point and the position information about the same; and finally filling the outline for displaying. The displayed handwriting trace has the same calligraphy of handwriting as characters written on paper.

摘要翻译： 提供了一种用于实现原始书法书法的方法和装置。 该方法包括：对接触点进行实时取样以获取关于取样点的位置信息和采样点的笔宽度; 确定由相邻采样点确定的行程的中心线; 根据中心线和采样点的笔宽确定关于相应笔画的关键点的位置信息; 将笔画的关键点划分成组，以确定其类型; 通过根据关键点的类型和关于该关键点的位置信息绘制圆弧和/或线来产生对应行程的书法轮廓; 最后填写轮廓显示。 显示的手写痕迹具有与写在纸上的字符相同的笔迹书法。