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1.发明授权Nucleic acid delivery system comprising conjugates of PEI and hyaluronic acid 有权包含PEI和透明质酸的缀合物的核酸递送系统公开(公告)号：US08318856B2
公开(公告)日：2012-11-27
申请号：US12733061
申请日：2008-04-04
Applicant: Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
Inventor： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
Abstract: The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding.
Abstract translation: 本发明涉及使用阳离子聚合物缀合物的核酸递送系统，并且更具体地涉及用于核酸的递送系统，其包含通过将透明质酸或其衍生物和聚乙烯亚胺缀合而制备的阳离子聚合物缀合物，以及递送 核酸进入哺乳动物细胞，其包含核酸和具有静电结合的阳离子聚合物缀合物的复合物。
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公开(公告)号：US07372981B2
公开(公告)日：2008-05-13
申请号：US10720198
申请日：2003-11-25
Applicant: Shang-Hong Lai , Jiang-Ge Chen , Yea-Shuan Huang
Inventor： Shang-Hong Lai , Jiang-Ge Chen , Yea-Shuan Huang
IPC: G06K9/00
CPC classification number: G06K9/00268
Abstract: A statistical facial feature extraction method is disclosed. In a training phase, N training face images are respectively labeled n feature points located in n different blocks to form N feature vectors. Next, a principal component analysis (PCA) technique is used to obtain a statistical face shape model after aligning each shape vector with a reference shape vector. In an executing phase, initial positions for desired facial features are firstly guessed according to the coordinates of the mean shape for aligned training face images obtained in the training phase, and k candidates are respectively labeled in n search ranges corresponding to above-mentioned initial positions to obtain kn different combinations of test shape vectors. Finally, coordinates of the test shape vector having the best similarity with the mean shape for aligned training face image and the statistical face shape model are assigned as facial features of the test face image.
Abstract translation: 公开了统计面部特征提取方法。 在训练阶段，N个训练面部图像分别标记在n个不同块中的n个特征点，以形成N个特征向量。 接下来，使用主成分分析（PCA）技术在将每个形状向量与参考形状向量对齐之后获得统计面部形状模型。 在执行阶段，首先根据在训练阶段获得的对齐训练面部图像的平均形状的坐标来猜测所需面部特征的初始位置，并且将k个候选分别标记在与上述初始位置对应的n个搜索范围内 以获得测试形状向量的不同组合。 最后，将具有与对准的训练面部图像的平均形状和统计面部形状模型最相似的测试形状向量的坐标分配为测试面部图像的面部特征。
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公开(公告)号：US20100144035A1
公开(公告)日：2010-06-10
申请号：US12733061
申请日：2008-04-04
Applicant: Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , II-Hwan Cho , Sei-Kwang Hahn
Inventor： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , II-Hwan Cho , Sei-Kwang Hahn
Abstract: The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding.
Abstract translation: 本发明涉及使用阳离子聚合物缀合物的核酸递送系统，并且更具体地涉及用于核酸的递送系统，其包含通过将透明质酸或其衍生物和聚乙烯亚胺缀合而制备的阳离子聚合物缀合物，以及递送 核酸进入哺乳动物细胞，其包含核酸和具有静电结合的阳离子聚合物缀合物的复合物。
