-
公开(公告)号:US08691856B2
公开(公告)日:2014-04-08
申请号:US12093601
申请日:2006-11-16
IPC分类号: A01N43/64 , A61K31/41 , C07D257/04 , C07D257/10 , C07D403/00 , C07D487/00
CPC分类号: C07D257/06 , C07D257/04
摘要: The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
摘要翻译: 本发明公开了具有胰高血糖素受体拮抗剂或反向激动剂活性的式(I)的新化合物或其药学上可接受的盐,以及制备这些化合物的方法。 在另一个实施方案中,本发明公开了包含式(I)化合物的药物组合物以及使用它们治疗糖尿病和其它与胰高血糖素相关的代谢紊乱等的方法。
-
公开(公告)号:US07696248B2
公开(公告)日:2010-04-13
申请号:US12093054
申请日:2006-11-07
申请人: Jianke Li , Scott Eugene Conner , Guoxin Zhu
发明人: Jianke Li , Scott Eugene Conner , Guoxin Zhu
IPC分类号: A61K31/195 , C07C229/00
CPC分类号: C07C237/36 , C07C255/50
摘要: The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
-
公开(公告)号:US20070249688A1
公开(公告)日:2007-10-25
申请号:US11570449
申请日:2005-06-08
申请人: Scott Conner , Guoxin Zhu , Jianke Li
发明人: Scott Conner , Guoxin Zhu , Jianke Li
IPC分类号: A61K31/195 , A61K31/44 , A61K31/4412 , A61P3/08 , C07C59/64 , C07D213/24 , C07D213/63
CPC分类号: C07D213/89 , C07C235/42 , C07C251/48 , C07C255/54 , C07C323/60 , C07C323/62 , C07C323/65 , C07C2601/02 , C07C2601/14 , C07D213/30 , C07D213/64 , C07D213/65 , C07D295/096 , C07D319/06 , C07D319/20
摘要: The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
摘要翻译: 本发明公开了具有胰高血糖素受体拮抗剂或反向激动剂活性的新颖的式I化合物或其药学上可接受的盐,以及制备这些化合物的方法。 在另一个实施方案中,本发明公开了包含式I化合物的药物组合物以及使用它们治疗糖尿病和其它与胰高血糖素相关的代谢紊乱等的方法。
-
公开(公告)号:US08609892B2
公开(公告)日:2013-12-17
申请号:US13013280
申请日:2011-01-25
申请人: Scott Eugene Conner , Guoxin Zhu , Jianke Li
发明人: Scott Eugene Conner , Guoxin Zhu , Jianke Li
IPC分类号: C07C323/60 , C07C235/42 , C07D213/62 , A61K31/197
CPC分类号: C07D213/89 , C07C235/42 , C07C251/48 , C07C255/54 , C07C323/60 , C07C323/62 , C07C323/65 , C07C2601/02 , C07C2601/14 , C07D213/30 , C07D213/64 , C07D213/65 , C07D295/096 , C07D319/06 , C07D319/20
摘要: The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
摘要翻译: 本发明公开了具有胰高血糖素受体拮抗剂或反向激动剂活性的新颖的式I化合物或其药学上可接受的盐,以及制备这些化合物的方法。 在另一个实施方案中,本发明公开了包含式I化合物的药物组合物以及使用它们治疗糖尿病和其它与胰高血糖素相关的代谢紊乱等的方法。
-
公开(公告)号:US08214719B1
公开(公告)日:2012-07-03
申请号:US12181172
申请日:2008-07-28
申请人: Hongying Sheng , Job Lam , Kai-Chuan Chang , Jianke Li
发明人: Hongying Sheng , Job Lam , Kai-Chuan Chang , Jianke Li
IPC分类号: G06F11/00
CPC分类号: G06F11/073 , G06F11/0745 , G06F11/0751
摘要: Some of the embodiments of the present disclosure provide a method comprising receiving a stream of codewords from a hard disk controller (HDC), receiving a write gate signal, the write gate signal configured to request a read/write (R/W) channel to write at least a first part of the stream of codewords to a media, and receiving a symbol count signal indicating a number of symbols in the first part of the received stream of codewords. Other embodiments are also described and claimed.
摘要翻译: 本公开的一些实施例提供了一种方法,包括从硬盘控制器(HDC)接收码字流,接收写入门信号,写入门信号被配置为请求读/写(R / W)信道 将码字流的至少第一部分写入介质,以及接收指示所接收的码字流的第一部分中的符号数量的符号计数信号。 还描述和要求保护其他实施例。
-
公开(公告)号:US08349883B2
公开(公告)日:2013-01-08
申请号:US13082956
申请日:2011-04-08
申请人: Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
发明人: Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
IPC分类号: A61K31/4162 , A61K31/4155
CPC分类号: C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要: The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐,水合物,酯和前药,其中R 1,R 2,R 3,Y,Z如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗,抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
-
7.
公开(公告)号:US20100324140A1
公开(公告)日:2010-12-23
申请号:US12868773
申请日:2010-08-26
申请人: Scott Eugene CONNER , Guoxin ZHU , Jianke LI
发明人: Scott Eugene CONNER , Guoxin ZHU , Jianke LI
IPC分类号: A61K31/197 , C07C229/38 , A61P3/10
CPC分类号: C07D213/89 , C07C235/42 , C07C251/48 , C07C255/54 , C07C323/60 , C07C323/62 , C07C323/65 , C07C2601/02 , C07C2601/14 , C07D213/30 , C07D213/64 , C07D213/65 , C07D295/096 , C07D319/06 , C07D319/20
摘要: The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
摘要翻译: 本发明公开了具有胰高血糖素受体拮抗剂或反向激动剂活性的新颖的式I化合物或其药学上可接受的盐,以及制备这些化合物的方法。 在另一个实施方案中,本发明公开了包含式I化合物的药物组合物以及使用它们治疗糖尿病和其它与胰高血糖素相关的代谢紊乱等的方法。
-
公开(公告)号:US20110053925A1
公开(公告)日:2011-03-03
申请号:US12870123
申请日:2010-08-27
申请人: Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
发明人: Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
IPC分类号: A61K31/537 , C12N5/00 , A61K31/5377 , A61K31/495 , A61K31/438 , A61K31/437 , A61K31/454 , C07D498/10 , C07D413/14 , C07D413/02 , C07D295/205 , C07D471/10 , C07D471/04 , C07D401/02 , A61P25/16 , A61P25/28 , A61P9/04 , A61P7/02 , A61P19/02 , A61P9/10 , A61P35/00
CPC分类号: C07D295/205 , C07D213/74 , C07D217/22 , C07D235/30 , C07D241/42 , C07D241/50 , C07D295/155 , C07D295/185 , C07D295/26 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D491/107 , C07D491/113 , C07D498/10
摘要: The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, ring A, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐,水合物,酯和前药,其中R1,R2,R3,环A,如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗,抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
-
公开(公告)号:US07863329B2
公开(公告)日:2011-01-04
申请号:US12093486
申请日:2006-11-14
申请人: Jianke Li , Guoxin Zhu
发明人: Jianke Li , Guoxin Zhu
IPC分类号: A61K31/166 , C07C229/28
CPC分类号: C07C233/83
摘要: The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
摘要翻译: 本发明公开了具有胰高血糖素受体拮抗剂或反向激动剂活性的新颖的式I化合物或其药学上可接受的盐,以及制备这些化合物的方法。 在另一个实施方案中,本发明公开了包含式I化合物的药物组合物以及使用它们治疗糖尿病和其它与胰高血糖素相关的代谢紊乱等的方法。
-
10.
公开(公告)号:US20090156655A1
公开(公告)日:2009-06-18
申请号:US12093601
申请日:2006-11-16
IPC分类号: A61K31/41 , C07D257/06 , A61P3/10
CPC分类号: C07D257/06 , C07D257/04
摘要: The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
摘要翻译: 本发明公开了具有胰高血糖素受体拮抗剂或反向激动剂活性的式(I)的新化合物或其药学上可接受的盐,以及制备这些化合物的方法。 在另一个实施方案中,本发明公开了包含式(I)化合物的药物组合物以及使用它们治疗糖尿病和其它与胰高血糖素相关的代谢紊乱等的方法。
-
-
-
-
-
-
-
-
-