公开(公告)号：US08853452B2

公开(公告)日：2014-10-07

申请号：US13148857

申请日：2010-02-09

申请人： Barbara S. Beckman ,  Maryam Foroozesh ,  Jiawang Liu

发明人： Barbara S. Beckman ,  Maryam Foroozesh ,  Jiawang Liu

IPC分类号： C07C233/05 ,  A61K31/65 ,  A61K31/165 ,  C07C233/65

CPC分类号： C07C233/60 ,  C07C215/24 ,  C07C233/21 ,  C07C237/06 ,  C07C251/24

摘要： Compounds and their syntheses are disclosed herein. Compositions and pharmaceutical compositions comprising a compound are also described, and include compositions also comprising liposomes. Methods for the treatment of cancer in animals comprising administering a compound or a composition comprising a compound are also described.

摘要翻译： 本文公开了化合物及其合成。 还描述了包含化合物的组合物和药物组合物，并且包括还包含脂质体的组合物。 还描述了用于治疗动物中癌症的方法，包括给予化合物或包含化合物的组合物。

公开(公告)号：US20140219961A1

公开(公告)日：2014-08-07

申请号：US14342715

申请日：2012-09-05

申请人： Sung Youb Jung ,  Young Eun Woo ,  Se Young Lim ,  In Young Choi ,  Jae Ho Lee ,  Se Chang Kwon ,  Sung Hwan Moon ,  Jiawang Liu

发明人： Sung Youb Jung ,  Young Eun Woo ,  Se Young Lim ,  In Young Choi ,  Jae Ho Lee ,  Se Chang Kwon ,  Sung Hwan Moon ,  Jiawang Liu

IPC分类号： A61K47/48 ,  A61K31/7068 ,  A61K38/21

CPC分类号： A61K47/642 ,  A61K9/0019 ,  A61K31/7068 ,  A61K38/212 ,  A61K47/60 ,  A61K47/68

摘要： A method for preventing or treating a cancer includes administering an anti-cancer pharmaceutical composition including an interferon alpha or a polymer conjugate thereof. The pharmaceutical composition can be co-administered with anti-cancer agents. The interferon alpha conjugate shows a longer in vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha, and in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition has excellent in vivo half-life and anti-cancer activity to greatly reduce administration frequency. Co-administration of an anti-cancer agent and the interferon alpha conjugate having excellent anti-cancer activity reduces administration dose of anti-cancer agent so as to reduce side effects of anti-cancer agent and increase treatment compliance of patient.

摘要翻译： 预防或治疗癌症的方法包括施用包含干扰素α或其聚合物缀合物的抗癌药物组合物。 药物组合物可与抗癌剂共同施用。 干扰素α缀合物显示比常规干扰素α更长的体内半衰期和更优异的抗癌活性，特别是其与抗癌药如吉西他滨的共同给药对癌细胞具有协同抑制作用 生长和增殖，以显示出非常优异的抗癌活性。 此外，抗癌药物组合物具有优异的体内半衰期和抗癌活性，从而大大降低给药频率。 共同施用抗癌剂和具有优异抗癌活性的干扰素α缀合物降低了抗癌剂的施用剂量，从而降低了抗癌剂的副作用并增加了患者的治疗依从性。

公开(公告)号：US09789202B2

公开(公告)日：2017-10-17

申请号：US14342715

申请日：2012-09-05

申请人： Sung Youb Jung ,  Young Eun Woo ,  Se Young Lim ,  In Young Choi ,  Jae Ho Lee ,  Se Chang Kwon ,  Sung Hwan Moon ,  Jiawang Liu

发明人： Sung Youb Jung ,  Young Eun Woo ,  Se Young Lim ,  In Young Choi ,  Jae Ho Lee ,  Se Chang Kwon ,  Sung Hwan Moon ,  Jiawang Liu

IPC分类号： A61K38/21 ,  A61K47/48 ,  A61K31/7068 ,  A61K9/00

CPC分类号： A61K47/642 ,  A61K9/0019 ,  A61K31/7068 ,  A61K38/212 ,  A61K47/60 ,  A61K47/68

摘要： A method for preventing or treating a cancer includes administering an anti-cancer pharmaceutical composition including an interferon alpha or a polymer conjugate thereof. The pharmaceutical composition can be co-administered with anti-cancer agents. The interferon alpha conjugate shows a longer in vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha, and in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition has excellent in vivo half-life and anti-cancer activity to greatly reduce administration frequency. Co-administration of an anti-cancer agent and the interferon alpha conjugate having excellent anti-cancer activity reduces administration dose of anti-cancer agent so as to reduce side effects of anti-cancer agent and increase treatment compliance of patient.

公开(公告)号：US20120027844A1

公开(公告)日：2012-02-02

申请号：US13148857

申请日：2010-02-09

申请人： Barbara S. Beckman ,  Maryam Foroozesh ,  Jiawang Liu

发明人： Barbara S. Beckman ,  Maryam Foroozesh ,  Jiawang Liu

IPC分类号： A61K31/16 ,  C07C231/08 ,  C07C211/27 ,  C07C209/60 ,  C07C251/24 ,  C07C249/02 ,  C07C233/18 ,  C07C237/10 ,  C07C237/20 ,  A61K9/127 ,  A61K31/133 ,  A61K31/137 ,  A61K31/165 ,  A61P35/00 ,  A61P35/02 ,  C07C233/60

CPC分类号： C07C233/60 ,  C07C215/24 ,  C07C233/21 ,  C07C237/06 ,  C07C251/24

摘要： Compounds and their syntheses are disclosed herein. Compositions and pharmaceutical compositions comprising a compound are also described, and include compositions also comprising liposomes. Methods for the treatment of cancer in animals comprising administering a compound or a composition comprising a compound are also described.

摘要翻译： 本文公开了化合物及其合成。 还描述了包含化合物的组合物和药物组合物，并且包括还包含脂质体的组合物。 还描述了用于治疗动物中癌症的方法，包括给予化合物或包含化合物的组合物。