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公开(公告)号:US20070185109A1
公开(公告)日:2007-08-09
申请号:US10599911
申请日:2005-04-13
申请人: Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hoe Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Jang Hyuk Lee , Sun Chul Huh , Jae Mok Lee , Seog Beom Song , Soon Ji Kwon , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
发明人: Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hoe Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Jang Hyuk Lee , Sun Chul Huh , Jae Mok Lee , Seog Beom Song , Soon Ji Kwon , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
IPC分类号: A61K31/5375 , A61K31/495 , A61K31/445 , A61K31/381
CPC分类号: C07D213/30 , C07C291/02 , C07C309/66 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D213/53 , C07D233/64 , C07D277/24 , C07D295/088 , C07D295/185 , C07D307/54 , C07D317/60 , C07D317/70 , C07D333/24 , C07D333/28 , C07D417/12
摘要: The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
摘要翻译: 式(I)的本发明的茚衍生物能够选择性调节过氧化物酶体增殖物激活受体(PPAR)的活性,不引起副作用,因此它们可用于治疗和预防由PPARs调节的病症, 糖尿病,肥胖,动脉硬化,高脂血症,高胰岛素血症和高血压等代谢综合征,骨质疏松症,肝硬化和哮喘等炎性疾病和癌症。